公开(公告)号：US20180208937A1

公开(公告)日：2018-07-26

申请号：US15758429

申请日：2016-09-08

Applicant: Bayer CropScience Aktiengesellschaft ,  BAYER CROPSCIENCE LP

Inventor： Marc Linka ,  Fabien POREE ,  Bernd LABER ,  Gudrun LANGE ,  Jan TEBBE ,  Wayne COCO ,  Michael STRERATH ,  Ernst WEBER ,  Nikolaus PAWLOWSKI ,  Sandra GESKE ,  Heike BALVEN-ROSS ,  Nina WOBST ,  Christina THIES ,  Manuel DUBALD

IPC: C12N15/82 ,  C12N9/02

CPC classification number: C12N15/8274 ,  C12N9/0069 ,  C12Y113/11027

Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described.A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors.In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.