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1.发明申请NEW ACTINOMYCETE INTEGRATIVE AND CONJUGATIVE ELEMENT FROM ACTINOPLANES SP. SE50/110 AS PLASMID FOR GENETIC TRANSFORMATION OF RELATED ACTINOBACTERIA 有权来自ACTINOPLANES SP的新型ACTINOMYCETE一体化和连接元件 SE50 / 110作为相关抗逆转录病毒遗传转化的PLASMID公开(公告)号：US20140349346A1
公开(公告)日：2014-11-27
申请号：US14363810
申请日：2012-12-04
发明人： Andreas Klein , Klaus Selber , Hermann Wehlmann , Winfried Rosen , Alfred Pühler , Patrick Schwientek , Jörn Kalinowski , Udo Wehmeier
摘要： The present invention is directed to an innate DNA sequence within the complete genome sequence of Actinoplanes sp. SE50/110 which resembles the structure of an actinomycete integrative and conjugative element (AICE). Related AICEs were used for establishing genetic manipulation tools for other bacteria in the past. In this document, we describe the unique features of the specific AICE found in Actinoplanes sp. SE50/110 which are clearly distinct from any other known AICE as a whole, but share minor parts with varying sequence similarity with other characterized AiCEs from other species.
摘要翻译： 本发明涉及一种在Actinoplanes sp。的完整基因组序列内的先天DNA序列。 SE50 / 110类似于放线菌综合和共轭元素（AICE）的结构。 相关的AICE用于建立过去其他细菌的遗传操作工具。 在本文中，我们描述了在Actinoplanes sp中发现的特定AICE的独特功能。 SE50 / 110与其他已知的AICE作为一个整体明显不同，但是与其他物种的其他特征的AiCE具有不同序列相似性的次要部分。
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2.发明授权Actinomycete integrative and conjugative element from Actinoplanes sp. SE50/110 as plasmid for genetic transformation of related actinobacteria 有权来自Actinoplanes sp。的放线菌综合和共轭元件 SE50 / 110作为相关放线菌遗传转化的质粒公开(公告)号：US09562249B2
公开(公告)日：2017-02-07
申请号：US14939495
申请日：2015-11-12
发明人： Andreas Klein , Klaus Selber , Hermann Wehlmann , Winfried Rosen , Alfred Pühler , Patrick Schwientek , Jörn Kalinowski , Udo Wehmeier
摘要： The present invention is directed to an innate DNA sequence within the complete genome sequence of Actinoplanes sp. SE50/110 which resembles the structure of an actinomycete integrative and conjugative element (AICE). Related AICEs were used for establishing genetic manipulation tools for other bacteria in the past. In this document, we describe the unique features of the specific AICE found in Actinoplanes sp. SE50/110 which are clearly distinct from any other known AICE as a whole, but share minor parts with varying sequence similarity with other characterized AICEs from other species.
摘要翻译： 本发明涉及一种在Actinoplanes sp。的完整基因组序列内的先天DNA序列。 SE50 / 110类似于放线菌综合和共轭元素（AICE）的结构。 相关的AICE用于建立过去其他细菌的遗传操作工具。 在本文中，我们描述了在Actinoplanes sp中发现的特定AICE的独特功能。 SE50 / 110与其他已知的AICE作为一个整体明显不同，但与其他物种的其他特征性AICE具有不同序列相似性的次要部分。
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3.发明授权Actinomycete integrative and conjugative element from Actinoplanes sp. SE50/110 as plasmid for genetic transformation of related Actinobacteria 有权来自Actinoplanes sp。的放线菌综合和共轭元件 SE50 / 110作为相关放线菌的遗传转化质粒公开(公告)号：US09217154B2
公开(公告)日：2015-12-22
申请号：US14363810
申请日：2012-12-04
发明人： Andreas Klein , Klaus Selber , Hermann Wehlmann , Winfried Rosen , Alfred Pühler , Patrick Schwientek , Jörn Kalinowski , Udo Wehmeier
摘要： The present invention is directed to an innate DNA sequence within the complete genome sequence of Actinoplanes sp. SE50/110 which resembles the structure of an actinomycete integrative and conjugative element (AICE). Related AICEs were used for establishing genetic manipulation tools for other bacteria in the past. In this document, we describe the unique features of the specific AICE found in Actinoplanes sp. SE50/110 which are clearly distinct from any other known AICE as a whole, but share minor parts with varying sequence similarity with other characterized AiCEs from other species.
摘要翻译： 本发明涉及一种在Actinoplanes sp。的完整基因组序列内的先天DNA序列。 SE50 / 110类似于放线菌综合和共轭元素（AICE）的结构。 相关的AICE用于建立过去其他细菌的遗传操作工具。 在本文中，我们描述了在Actinoplanes sp中发现的特定AICE的独特功能。 SE50 / 110与其他已知的AICE作为一个整体明显不同，但与其他物种的其他特征的AiCE具有不同序列相似性的次要部分。
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