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公开(公告)号：US09719064B2
公开(公告)日：2017-08-01
申请号：US13814235
申请日：2011-08-01
申请人： Klaus Selber , Bernhard Weingaertner , Hermann Wehlmann , Winfried Rosen , Alfred Pühler , Patrick Schwientek , Jörn Kalinowski , Udo Wehmeier
发明人： Klaus Selber , Bernhard Weingaertner , Hermann Wehlmann , Winfried Rosen , Alfred Pühler , Patrick Schwientek , Jörn Kalinowski , Udo Wehmeier
IPC分类号： C12N1/20 , C07K14/365 , C12P19/26
CPC分类号： C12N1/20 , C07K14/365 , C12P19/26
摘要： The present invention describes the DNA-sequence of the wild type genome as well as all genetic modifications which were introduced into the wild type—and further developed strains, based thereon. Thereby the first genotypic characterization of the developed strains, including the latest production strain, has been accomplished, accounting for the major part of the invention. Furthermore, on the basis of the determined DNA-sequences, potential genes were identified and account, combined with their functional annotation, for another part of the invention. In particular, the gene- and DNA-sequences, as well as protein-sequences derived there out, contribute to the invention which were affected by mutagenic modifications throughout the strain development process, potentially contributing to the increased production yield.
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2.发明授权Actinomycete integrative and conjugative element from Actinoplanes sp. SE50/110 as plasmid for genetic transformation of related Actinobacteria 有权来自Actinoplanes sp。的放线菌综合和共轭元件 SE50 / 110作为相关放线菌的遗传转化质粒公开(公告)号：US09217154B2
公开(公告)日：2015-12-22
申请号：US14363810
申请日：2012-12-04
发明人： Andreas Klein , Klaus Selber , Hermann Wehlmann , Winfried Rosen , Alfred Pühler , Patrick Schwientek , Jörn Kalinowski , Udo Wehmeier
摘要： The present invention is directed to an innate DNA sequence within the complete genome sequence of Actinoplanes sp. SE50/110 which resembles the structure of an actinomycete integrative and conjugative element (AICE). Related AICEs were used for establishing genetic manipulation tools for other bacteria in the past. In this document, we describe the unique features of the specific AICE found in Actinoplanes sp. SE50/110 which are clearly distinct from any other known AICE as a whole, but share minor parts with varying sequence similarity with other characterized AiCEs from other species.
摘要翻译： 本发明涉及一种在Actinoplanes sp。的完整基因组序列内的先天DNA序列。 SE50 / 110类似于放线菌综合和共轭元素（AICE）的结构。 相关的AICE用于建立过去其他细菌的遗传操作工具。 在本文中，我们描述了在Actinoplanes sp中发现的特定AICE的独特功能。 SE50 / 110与其他已知的AICE作为一个整体明显不同，但与其他物种的其他特征的AiCE具有不同序列相似性的次要部分。
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3.发明授权Lantibiotic biosynthetic gene clusters from A. garbadinensis and A. Liguriae 有权来自A. garbadinensis和A.Liguriae的Lantibiotic生物合成基因簇公开(公告)号：US07989416B2
公开(公告)日：2011-08-02
申请号：US12161221
申请日：2007-01-17
CPC分类号： C07K14/365 , C12R1/045
摘要： Characterization of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine are described.
摘要翻译： 描述了羊毛硫抗生素卡氨酸的生物合成基因簇的鉴定，阿加瓜定及其生物合成簇的新变体的鉴定，以及阿加胍的生产和使用方法。
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公开(公告)号：US07018334B2
公开(公告)日：2006-03-28
申请号：US10474307
申请日：2002-04-08
申请人： Henry M. Israel
发明人： Henry M. Israel
IPC分类号： A61B8/00
CPC分类号： G01N21/4795 , A61B5/0051 , A61B5/0073 , C07K14/365 , C12N15/52 , G01N2021/479
摘要： A method for imaging a region in a scattering medium, comprising modulating a beam of energy passing through a region of a scattering medium by at least two ultrasonic energy waves having different spatial relationships with said beam of energy so as to form at least two different modulated energy patterns, and detecting and processing said modulated energy patterns to form an image of said region.
摘要翻译： 一种用于对散射介质中的区域进行成像的方法，包括通过与所述能量束具有不同空间关系的至少两个超声波能量来调制通过散射介质的区域的能量束，以便形成至少两个不同的调制 能量图案，以及检测和处理所述调制的能量图案以形成所述区域的图像。
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5.发明申请Gene encoding a nonribosomal peptide synthetase for the production of ramoplanin 失效编码非核糖体多肽合成酶的基因用于产生拉莫拉宁公开(公告)号：US20050287641A1
公开(公告)日：2005-12-29
申请号：US11205109
申请日：2005-08-17
IPC分类号： C12N15/09 , C07H21/04 , C07K9/00 , C07K14/365 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/52 , C12N15/31 , C12N15/52 , C12P21/06
CPC分类号： C07K14/365 , C12N15/52
摘要： The present invention relates to isolated genetic sequences encoding nonribosomal peptide synthetase (NRPS) proteins which direct the biosynthesis of the antibiotic ramoplanin in microorganisms such as Actinoplanes sp. The isolated gene sequences serve as substrates for bioengineering of antibiotic structures.
摘要翻译： 本发明涉及编码非核糖体肽合成酶（NRPS）蛋白质的分离的遗传序列，其指导抗微生物如抗生素拉莫拉宁的生物合成，例如Actinoplanes sp。 分离的基因序列作为抗生素结构生物工程的底物。
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公开(公告)号：US4336249A
公开(公告)日：1982-06-22
申请号：US41501
申请日：1979-05-22
申请人： Mamoru Arai , Akio Torikata , Ryuzou Enokita , Tatsuo Haneishi , Mutsuo Nakajima
发明人： Mamoru Arai , Akio Torikata , Ryuzou Enokita , Tatsuo Haneishi , Mutsuo Nakajima
IPC分类号： C12P21/00 , A61K35/74 , A61K38/00 , A61P31/04 , C07G11/00 , C07K7/50 , C07K11/02 , C07K14/195 , C07K14/365 , C07K14/41 , C12P1/06 , C12R1/045 , A61K35/00
CPC分类号： C12R1/045 , C07K14/365 , C12P1/06 , Y10S435/827
摘要： A novel antibiotic substance, named "Mycoplanecin", of presently unknown structural formula, is produced by cultivating a Mycoplanecin-producing microorganism of the genus Actinoplanes, especially the Actinoplanes nov. sp. Strain No. 41042, NRRL No. 11462.
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公开(公告)号：US20150291670A1
公开(公告)日：2015-10-15
申请号：US14414446
申请日：2012-07-12
申请人： Marianna Iorio , Sonia Maffioli , Paolo Monciardini , Margherita Sosio , Stefano Donadio , Rosalia Bertorelli , Oscar Sasso , Angelo Reggiani
发明人： Marianna Iorio , Sonia Maffioli , Paolo Monciardini , Margherita Sosio , Stefano Donadio , Rosalia Bertorelli , Oscar Sasso , Angelo Reggiani
IPC分类号： C07K14/365 , C12R1/045
CPC分类号： C07K14/365 , A61K38/00 , C12R1/045
摘要： The present invention concerns novel lantipeptide (lanthionine-containing peptide) compounds having general formula (I), a process for their preparation, the key intermediates in said processes, their pharmaceutical acceptable salts and pharmaceutical compositions containing them, as well as their use in the treatment of pain.
摘要翻译： 本发明涉及具有通式（I）的新型多肽（含有羊血硫素的肽）化合物，其制备方法，所述方法中的关键中间体，其药学上可接受的盐和含有它们的药物组合物，以及它们在 治疗疼痛。
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8.发明申请NEW ACTINOMYCETE INTEGRATIVE AND CONJUGATIVE ELEMENT FROM ACTINOPLANES SP. SE50/110 AS PLASMID FOR GENETIC TRANSFORMATION OF RELATED ACTINOBACTERIA 有权来自ACTINOPLANES SP的新型ACTINOMYCETE一体化和连接元件 SE50 / 110作为相关抗逆转录病毒遗传转化的PLASMID公开(公告)号：US20140349346A1
公开(公告)日：2014-11-27
申请号：US14363810
申请日：2012-12-04
发明人： Andreas Klein , Klaus Selber , Hermann Wehlmann , Winfried Rosen , Alfred Pühler , Patrick Schwientek , Jörn Kalinowski , Udo Wehmeier
摘要： The present invention is directed to an innate DNA sequence within the complete genome sequence of Actinoplanes sp. SE50/110 which resembles the structure of an actinomycete integrative and conjugative element (AICE). Related AICEs were used for establishing genetic manipulation tools for other bacteria in the past. In this document, we describe the unique features of the specific AICE found in Actinoplanes sp. SE50/110 which are clearly distinct from any other known AICE as a whole, but share minor parts with varying sequence similarity with other characterized AiCEs from other species.
摘要翻译： 本发明涉及一种在Actinoplanes sp。的完整基因组序列内的先天DNA序列。 SE50 / 110类似于放线菌综合和共轭元素（AICE）的结构。 相关的AICE用于建立过去其他细菌的遗传操作工具。 在本文中，我们描述了在Actinoplanes sp中发现的特定AICE的独特功能。 SE50 / 110与其他已知的AICE作为一个整体明显不同，但是与其他物种的其他特征的AiCE具有不同序列相似性的次要部分。
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9.发明授权Lantibiotic biosynthetic gene clusters from A. garbadinensis and A. liguriae 失效来自加尔丁（A. Garbadinensis）和百里香肠杆菌（A.tururiae）的Lantibiotic生物合成基因簇公开(公告)号：US08465947B2
公开(公告)日：2013-06-18
申请号：US13157454
申请日：2011-06-10
CPC分类号： C07K14/365 , C12R1/045
摘要： Characterization of the biosynthetic gene cluster for the lantibiotic antibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine, a novel actagardine variant, herein referred to as actagardine B, and variants of both of these produced according to this invention, utilizing genes from the characterized biosynthetic gene clusters, is described.
摘要翻译： 用于羊毛硫抗生素抗生素卡肽的生物合成基因簇的鉴定，阿加瓜定及其生物合成簇的新型变体的鉴定，以及生产和使用阿格达肽（一种新颖的阿格达肽变体）的方法，本文称为卡那加丁B，以及两者的变体 描述了根据本发明产生的利用表征的生物合成基因簇的基因的这些。
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10.发明授权Gene encoding a nonribosomal peptide synthetase for the production of ramoplanin 失效编码非核糖体多肽合成酶的基因用于产生拉莫拉宁公开(公告)号：US07635765B2
公开(公告)日：2009-12-22
申请号：US11205109
申请日：2005-08-17
CPC分类号： C07K14/365 , C12N15/52
摘要： The present invention relates to isolated genetic sequences encoding nonribosomal peptide synthetase (NRPS) proteins which direct the biosynthesis of the antibiotic ramoplanin in microorganisms such as Actinoplanes sp. The isolated gene sequences serve as substrates for bioengineering of antibiotic structures.
摘要翻译： 本发明涉及编码非核糖体肽合成酶（NRPS）蛋白质的分离的遗传序列，其指导抗微生物如抗生素拉莫拉宁的生物合成，例如Actinoplanes sp。 分离的基因序列作为抗生素结构生物工程的底物。
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