公开(公告)号：US20090076140A1

公开(公告)日：2009-03-19

申请号：US12264000

申请日：2008-11-03

申请人： Beatriz Maria Banfi Tosi ,  Guillermo Gimenez Gallego ,  Serafin Valverde Lopez ,  Rosa Maria Lozano Puerto ,  Pedro Sanchez Cuevas

发明人： Beatriz Maria Banfi Tosi ,  Guillermo Gimenez Gallego ,  Serafin Valverde Lopez ,  Rosa Maria Lozano Puerto ,  Pedro Sanchez Cuevas

IPC分类号： A61K31/255 ,  A61P19/02 ,  A61P17/06 ,  A61P3/04 ,  A61P9/10

CPC分类号： A61K31/47 ,  A61K31/185

摘要： A naphthalenesulfonic acid or quinolinesulfonic acid of formula (I), wherein A is N or a CR8 formula group, where R8 is H, OH, NR10OR11, independently from one another, where R10 and R11 represent H or C1-C6 alkyl or a group of formula NH—CO—R12, where R12 is C1-C6 alkyl or C6-C10 aryl; R1 and R2 represent H or SO3R9, independently from one another, where R9 is H, ammonium or a cation of an alkali or alkaline-earth metal; R3 is H or OH; and R4, R5, R6 and R7 represent H, an NR10R11 or NH—CO—R12 group, independently from one another; on the condition that (i) at least one of R1 or R2 is SO3R9, and (ii) at least one of R4, R5, R6 or R7 is an NR10R11 or NH—CO—R12 group, or their pharmaceutically acceptable salts; and a pharmaceutically acceptable excipient.

摘要翻译： 式（I）的萘磺酸或喹啉磺酸，其中A为N或CR 8式基团，其中R 8为H，OH，NR 10 OR 11，彼此独立地为R 10和R 11表示H或C 1 -C 6烷基或基团 式NH-CO-R12，其中R12是C1-C6烷基或C6-C10芳基; R1和R2彼此独立地表示H或SO3R9，其中R9是H，铵或碱金属或碱土金属的阳离子; R3为H或OH; R4，R5，R6和R7彼此独立地表示H，NR10R11或NH-CO-R12基团; 在（i）R 1或R 2中的至少一个为SO 3 R 9的情况下，和（ii）R 4，R 5，R 6或R 7中的至少一个为NR 10 R 11或NH-CO-R 12基团或其药学上可接受的盐; 和药学上可接受的赋形剂。