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1.发明授权公开(公告)号：US10144916B2
公开(公告)日：2018-12-04
申请号：US15304830
申请日：2015-05-08
Applicant: Becton, Dickinson and Company
Inventor： Jody Martin , Jason G. Vidal , Christian T. Carson
IPC: C12N5/077 , G01N33/569
Abstract: Methods are provided for distinguishing a cardiomyocyte subset in a heterogeneous cellular sample. Aspects of the methods include contacting the heterogeneous cellular sample with a cell surface marker specific binding member, and then distinguishing a cardiomyocyte subset of the cellular sample based on binding to the cell surface marker specific binding member. Also provided are devices, compositions and kits that find use in performing the subject methods.
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2.发明申请Cell-Surface Signatures for Isolating Neurons from Cell Cultures Derived from Pluripotent Stem Cells 有权用于分离来自多能干细胞的细胞培养物的神经细胞的细胞表面标记公开(公告)号：US20150050667A1
公开(公告)日：2015-02-19
申请号：US14381547
申请日：2013-04-23
Applicant: Becton, Dickinson and Company
Inventor： Christian T. Carson , Jody Martin , Jason G. Vidal
IPC: G01N33/569
CPC classification number: G01N33/56966 , G01N33/56977 , G01N2333/7055 , G01N2333/70596 , G01N2333/71
Abstract: The inventors disclose methods and systems that provide for the isolation and purification of neurons directly from heterogeneous cell cultures. The expression of various cell adhesion molecules was examined in pluripotent stem cells. Changes in the expression of one or more of these molecules correlates with the progression of cells from non-lineage committed to neural cells. Using one or more antibodies for these molecules in combination with antibodies specific for CD200 will enable one to identify and isolate neurons from a population cells.
Abstract translation: 本发明人公开了提供从异质细胞培养物直接分离和纯化神经元的方法和系统。 在多能干细胞中检测各种细胞粘附分子的表达。 这些分子中的一个或多个表达的变化与从非谱系致神经细胞的细胞进展相关。 将这些分子的一种或多种抗体与CD200特异性抗体结合使用，可以从群体细胞中鉴定和分离神经元。
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3.发明申请公开(公告)号：US20170153236A1
公开(公告)日：2017-06-01
申请号：US15304830
申请日：2015-05-08
Applicant: Becton, Dickinson and Company
Inventor： Jody Martin , Jason G. Vidal , Christian T. Carson
IPC: G01N33/569 , C12N5/077
CPC classification number: G01N33/56966 , C12N5/0657 , G01N2333/70596
Abstract: Methods are provided for distinguishing a cardiomyocyte subset in a heterogeneous cellular sample. Aspects of the methods include contacting the heterogeneous cellular sample with a cell surface marker specific binding member, and then distinguishing a cardiomyocyte subset of the cellular sample based on binding to the cell surface marker specific binding member. Also provided are devices, compositions and kits that fmd use in performing the subject methods.
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4.发明授权Cell-surface signatures for isolating neurons from cell cultures derived from pluripotent stem cells 有权从多能干细胞衍生的细胞培养物中分离神经元的细胞表面特征公开(公告)号：US09341625B2
公开(公告)日：2016-05-17
申请号：US14381547
申请日：2013-04-23
Applicant: Becton, Dickinson and Company
Inventor： Christian T. Carson , Jody Martin , Jason G. Vidal
IPC: G01N33/569
CPC classification number: G01N33/56966 , G01N33/56977 , G01N2333/7055 , G01N2333/70596 , G01N2333/71
Abstract: The inventors disclose methods and systems that provide for the isolation and purification of neurons directly from heterogeneous cell cultures. The expression of various cell adhesion molecules was examined in pluripotent stem cells. Changes in the expression of one or more of these molecules correlates with the progression of cells from non-lineage committed to neural cells. Using one or more antibodies for these molecules in combination with antibodies specific for CD200 will enable one to identify and isolate neurons from a population cells.
Abstract translation: 本发明人公开了提供从异质细胞培养物直接分离和纯化神经元的方法和系统。 在多能干细胞中检测各种细胞粘附分子的表达。 这些分子中的一个或多个表达的变化与从非谱系致神经细胞的细胞进展相关。 将这些分子的一种或多种抗体与CD200特异性抗体结合使用，可以从群体细胞中鉴定和分离神经元。
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