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    Novel Compounds and Uses Thereof
    1.
    发明申请
    Novel Compounds and Uses Thereof 有权
    新型化合物及其用途

    公开(公告)号：US20160137646A1

    公开(公告)日：2016-05-19

    申请号：US14894214

    申请日：2014-05-30

    Applicant: Ben C. ASKEW ,  Andrew GOOD ,  Kala Pharmaceuticals, Inc.

    Inventor： Winston Zapanta Ong ,  Pawel Wojciech Nowak ,  Ben C. Askew ,  Andrew Good

    IPC: C07D487/04 ,  C07D519/00

    CPC classification number: C07D487/04 ,  C07D519/00

    Abstract: The present invention provides novel compounds of any one of Formulae (I)-(IV), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of any one of Formulae (I)-(IV) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor signaling pathway (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.

    Abstract translation: 本发明提供式（I） - （IV）中任一项的新化合物及其药物组合物。 还提供了包含粘液穿透的式（I） - （IV）中任一项的化合物及其药物组合物的颗粒（例如纳米颗粒）。 本发明还提供了用于使用本发明化合物及其药物组合物用于治疗和/或预防与生长因子信号传导途径的异常或病理性血管生成和/或异常信号传导相关的疾病的方法和试剂盒（例如，血管内皮生长因子 VEGF）），例如增殖性疾病（例如癌症，良性肿瘤，炎症性疾病，自身免疫性疾病）和眼部疾病（例如，黄斑变性，青光眼，糖尿病性视网膜病变，视网膜母细胞瘤，水肿，葡萄膜炎，干眼症，睑炎炎， 手术炎症）。

    Urea derivatives and uses thereof
    2.
    发明授权
    Urea derivatives and uses thereof 有权

    公开(公告)号：US11352343B2

    公开(公告)日：2022-06-07

    申请号：US16900657

    申请日：2020-06-12

    Applicant: Kala Pharmaceuticals, Inc.

    Inventor： Winston Zapanta Ong ,  Pawel Wojciech Nowak ,  John Thomas Feutrill ,  Jinsoo Kim

    IPC: C07D413/14 ,  A61P35/00 ,  C07D403/10 ,  A61K9/00 ,  A61K9/14 ,  C07D471/04 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  A61K31/416

    Abstract: The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.

    UREA DERIVATIVES AND USES THEREOF
    9.
    发明申请
    UREA DERIVATIVES AND USES THEREOF 有权
    尿素衍生物及其用途

    公开(公告)号：US20150072986A1

    公开(公告)日：2015-03-12

    申请号：US14301653

    申请日：2014-06-11

    Applicant: Kala Pharmaceuticals, Inc.

    Inventor： Winston Zapanta Ong ,  Pawel Wojciech Nowak ,  John Thomas Feutrill ,  Jinsoo Kim ,  Minh Ngoc Nguyen ,  Elizabeth Enlow

    IPC: C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  C07D471/04

    CPC classification number: C07D403/10 ,  A61K9/0048 ,  A61K9/146 ,  A61K31/416 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  C07D471/04

    Abstract: The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.

    Abstract translation: 本发明提供式（I） - （III）中任一项的新化合物及其药物组合物。 还提供包含粘液穿透的式（I） - （III）化合物及其药物组合物的颗粒（例如纳米颗粒）。 本发明还提供了用于使用本发明化合物及其药物组合物用于治疗和/或预防与生长因子（例如血管内皮生长因子（VEGF））的异常或病理性血管生成和/或异常信号传导相关的疾病的方法和试剂盒， ），例如增殖性疾病（例如癌症，良性肿瘤，炎性疾病，自身免疫性疾病）和眼部疾病（例如黄斑变性，青光眼，糖尿病性视网膜病变，视网膜母细胞瘤，水肿，葡萄膜炎，干眼症，睑炎炎和手术后炎症 ）在有需要的受试者中。

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