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公开(公告)号：US07136695B2
公开(公告)日：2006-11-14
申请号：US09977052
申请日：2001-10-12
申请人： Benjamin D. Pless , Thomas K. Tcheng , Eyad Kishawi , Barbara Gibb , Javier Echauz , Rosana Esteller
发明人： Benjamin D. Pless , Thomas K. Tcheng , Eyad Kishawi , Barbara Gibb , Javier Echauz , Rosana Esteller
IPC分类号： A61B5/0476 , A61N1/18
CPC分类号： G06F19/3418 , A61B5/0476 , A61B5/4094 , A61B5/7217 , G06F19/00
摘要： An epileptiform activity patient-specific template creation system permits a user to efficiently develop an optimized set of patient-specific parameters for epileptiform activity detection algorithms. The epileptiform activity patient template creation system is primarily directed for use with an implantable neurostimulator system having EEG storage capability, in conjunction with a computer software program operating within a computer workstation having a processor, disk storage and input/output facilities for storing, processing and displaying patient EEG signals. The implantable neurostimulator is operative to store records of EEG data when neurological events are detected, when it receives external commands to record, or at preset or random times. The computer workstation operates on stored and uploaded records of EEG data to derive the patient-specific templates.
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公开(公告)号：US20170291026A1
公开(公告)日：2017-10-12
申请号：US15635006
申请日：2017-06-27
CPC分类号： A61N1/0553 , A61N1/0556 , H05K1/118
摘要： Devices, systems and methods are provided for stimulation of tissues and structures within a body of a patient. In particular, implantable leads are provided which are comprised of a flexible circuit. Typically, the flexible circuit includes an array of conductors bonded to a thin dielectric film. Example dielectric films include polyimide, polyvinylidene fluoride (PVDF) or other biocompatible materials to name a few. Such leads are particularly suitable for stimulation of the spinal anatomy, more particularly suitable for stimulation of specific nerve anatomies, such as the dorsal root (optionally including the dorsal root ganglion).
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公开(公告)号：US08249701B2
公开(公告)日：2012-08-21
申请号：US12579179
申请日：2009-10-14
申请人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
发明人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36146 , A61N1/36185
摘要： Methods, devices and systems are provided to efficiently identify, from among a plurality of possible neurostimulation parameter sets, one or more preferred neurostimulation parameter sets that treat a targeted pain of a patient. Each neurostimulation parameter set defines electrode parameters and neurostimulation signal parameters. A plurality of different neurostimulation parameter sets are tested on the patient to thereby identify those tested neurostimulation parameter sets that treat the targeted pain. Each of the tested neurostimulation parameter sets defines an electrode configuration that differs from the other tested neurostimulation parameter sets. All of the tested neurostimulation parameter sets comprise a same value for a specific neurostimulation signal parameter (e.g., pulse width) that if reduced reduces power consumption. If more than one of the tested neurostimulation parameter sets are identified as treating the targeted pain, then neurostimulation parameter sets identified as treating the targeted pain are retested, with the value for the specific neurostimulation signal parameter reduced by a same amount for each of the retested neurostimulation parameter sets, to thereby identify those neurostimulation parameter sets that treat the targeted pain at the reduced power consumption level.
摘要翻译： 提供了方法，装置和系统以有效地从多个可能的神经刺激参数组中识别治疗患者的目标疼痛的一个或多个优选的神经刺激参数组。 每个神经刺激参数集定义电极参数和神经刺激信号参数。 在患者身上测试多个不同的神经刺激参数组，从而识别那些用于治疗目标疼痛的神经刺激参数组。 每个测试的神经刺激参数集定义了与其他测试的神经刺激参数组不同的电极配置。 所有测试的神经刺激参数组对于特定神经刺激信号参数（例如，脉冲宽度）包含相同的值，如果降低，则减少功率消耗。 如果将多于一个测试的神经刺激参数集合识别为治疗目标疼痛，则重新测定被鉴定为治疗目标疼痛的神经刺激参数集，其中针对每个重新测试的特定神经刺激信号参数的值减少相同的量 神经刺激参数集，从而识别在降低的功耗水平下治疗目标疼痛的神经刺激参数组。
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4.发明申请公开(公告)号：US20100137938A1
公开(公告)日：2010-06-03
申请号：US12607009
申请日：2009-10-27
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36157 , A61N1/37247
摘要： Devices, systems and methods are provided for targeted treatment of a variety of conditions, particularly conditions that are associated with or influenced by the nervous system, such as pain. Targeted treatment of such conditions is provided with minimal deleterious side effects, such as undesired motor responses or undesired stimulation of unaffected body regions. This is achieved by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies.
摘要翻译： 提供装置，系统和方法用于各种条件的靶向治疗，特别是与神经系统相关或受其影响的条件，例如疼痛。 提供这种病症的靶向治疗具有最小的有害副作用，例如不期望的运动反应或不受影响的身体区域的刺激。 这是通过直接神经调节与病症相关的目标解剖结构来实现的，同时最小化或排除其他解剖结构的不希望的神经调节。
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公开(公告)号：US20080140152A1
公开(公告)日：2008-06-12
申请号：US11952062
申请日：2007-12-06
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/0556 , H05K1/118
摘要： Devices, systems and methods are provided for stimulation of tissues and structures within a body of a patient. In particular, implantable leads are provided which are comprised of a flexible circuit. Typically, the flexible circuit includes an array of conductors bonded to a thin dielectric film. Example dielectric films include polyimide, polyvinylidene fluoride (PVDF) or other biocompatible materials to name a few. Such leads are particularly suitable for stimulation of the spinal anatomy, more particularly suitable for stimulation of specific nerve anatomies, such as the dorsal root (optionally including the dorsal root ganglion).
摘要翻译： 提供装置，系统和方法用于刺激患者体内的组织和结构。 特别地，提供了由柔性电路组成的可植入引线。 通常，柔性电路包括结合到薄介电膜的导体阵列。 示例性电介质膜包括聚酰亚胺，聚偏二氟乙烯（PVDF）或其它生物相容性材料。 这种引线特别适用于刺激脊柱解剖结构，更特别适用于刺激特定的神经解剖结构，例如背根（任选地包括背根神经节）。
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6.发明授权公开(公告)号：US09056197B2
公开(公告)日：2015-06-16
申请号：US12607009
申请日：2009-10-27
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36157 , A61N1/37247
摘要： Devices, systems and methods are provided for targeted treatment of a variety of conditions, particularly conditions that are associated with or influenced by the nervous system, such as pain. Targeted treatment of such conditions is provided with minimal deleterious side effects, such as undesired motor responses or undesired stimulation of unaffected body regions. This is achieved by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies.
摘要翻译： 提供装置，系统和方法用于各种条件的靶向治疗，特别是与神经系统相关或受其影响的条件，例如疼痛。 提供这种病症的靶向治疗具有最小的有害副作用，例如不期望的运动反应或不受影响的身体区域的刺激。 这是通过直接神经调节与病症相关的目标解剖结构来实现的，同时最小化或排除其他解剖结构的不希望的神经调节。
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公开(公告)号：US08914128B2
公开(公告)日：2014-12-16
申请号：US13558271
申请日：2012-07-25
申请人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
发明人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36146 , A61N1/36185
摘要： Methods, devices and systems are provided to efficiently identify, from among a plurality of possible neurostimulation parameter sets, one or more preferred neurostimulation parameter sets that treat a targeted pain of a patient. A plurality of different neurostimulation parameter sets are tested on the patient to thereby identify those tested neurostimulation parameter sets that treat the targeted pain. Each of the tested neurostimulation parameter sets defines an electrode configuration that differs from the other tested neurostimulation parameter sets. If more than one of the tested neurostimulation parameter sets are identified as treating the targeted pain, then neurostimulation parameter sets identified as treating the targeted pain are retested, with the value for a specific neurostimulation signal parameter reduced by a same amount for each of the retested neurostimulation parameter sets, to thereby identify those neurostimulation parameter sets that treat the targeted pain at the reduced power consumption level.
摘要翻译： 提供了方法，装置和系统以有效地从多个可能的神经刺激参数组中识别治疗患者的目标疼痛的一个或多个优选的神经刺激参数组。 在患者身上测试多个不同的神经刺激参数组，从而识别那些用于治疗目标疼痛的神经刺激参数组。 每个测试的神经刺激参数集定义了与其他测试的神经刺激参数组不同的电极配置。 如果将多于一个测试的神经刺激参数集合识别为治疗目标疼痛，则重新测定被鉴定为治疗目标疼痛的神经刺激参数集，对于每个重新测试的特定神经刺激信号参数的值减少相同的量 神经刺激参数集，从而识别在降低的功耗水平下治疗目标疼痛的神经刺激参数组。
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公开(公告)号：US20100121408A1
公开(公告)日：2010-05-13
申请号：US12579179
申请日：2009-10-14
申请人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
发明人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36146 , A61N1/36185
摘要： Methods, devices and systems are provided to efficiently identify, from among a plurality of possible neurostimulation parameter sets, one or more preferred neurostimulation parameter sets that treat a targeted pain of a patient. Each neurostimulation parameter set defines electrode parameters and neurostimulation signal parameters. A plurality of different neurostimulation parameter sets are tested on the patient to thereby identify those tested neurostimulation parameter sets that treat the targeted pain. Each of the tested neurostimulation parameter sets defines an electrode configuration that differs from the other tested neurostimulation parameter sets. All of the tested neurostimulation parameter sets comprise a same value for a specific neurostimulation signal parameter (e.g., pulse width) that if reduced reduces power consumption. If more than one of the tested neurostimulation parameter sets are identified as treating the targeted pain, then neurostimulation parameter sets identified as treating the targeted pain are retested, with the value for the specific neurostimulation signal parameter reduced by a same amount for each of the retested neurostimulation parameter sets, to thereby identify those neurostimulation parameter sets that treat the targeted pain at the reduced power consumption level.
摘要翻译： 提供了方法，装置和系统以有效地从多个可能的神经刺激参数组中识别治疗患者的目标疼痛的一个或多个优选的神经刺激参数组。 每个神经刺激参数集定义电极参数和神经刺激信号参数。 在患者身上测试多个不同的神经刺激参数组，从而识别那些用于治疗目标疼痛的神经刺激参数组。 每个测试的神经刺激参数集定义了与其他测试的神经刺激参数组不同的电极配置。 所有测试的神经刺激参数组对于特定神经刺激信号参数（例如，脉冲宽度）包含相同的值，如果减少，则降低功率消耗。 如果将多于一个测试的神经刺激参数集合识别为治疗目标疼痛，则重新测定被鉴定为治疗目标疼痛的神经刺激参数集，其中针对每个重新测试的特定神经刺激信号参数的值减少相同的量 神经刺激参数集，从而识别在降低的功耗水平下治疗目标疼痛的神经刺激参数组。
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公开(公告)号：US09314618B2
公开(公告)日：2016-04-19
申请号：US11952062
申请日：2007-12-06
CPC分类号： A61N1/0553 , A61N1/0556 , H05K1/118
摘要： Devices, systems and methods are provided for stimulation of tissues and structures within a body of a patient. In particular, implantable leads are provided which are comprised of a flexible circuit. Typically, the flexible circuit includes an array of conductors bonded to a thin dielectric film. Example dielectric films include polyimide, polyvinylidene fluoride (PVDF) or other biocompatible materials to name a few. Such leads are particularly suitable for stimulation of the spinal anatomy, more particularly suitable for stimulation of specific nerve anatomies, such as the dorsal root (optionally including the dorsal root ganglion).
摘要翻译： 提供装置，系统和方法用于刺激患者体内的组织和结构。 特别地，提供了由柔性电路组成的可植入引线。 通常，柔性电路包括结合到薄介电膜的导体阵列。 示例性电介质膜包括聚酰亚胺，聚偏二氟乙烯（PVDF）或其它生物相容性材料。 这种引线特别适用于刺激脊柱解剖结构，更特别适用于刺激特定的神经解剖结构，例如背根（任选地包括背根神经节）。
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公开(公告)号：US20120290042A1
公开(公告)日：2012-11-15
申请号：US13558271
申请日：2012-07-25
申请人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
发明人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
IPC分类号： A61N1/36
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36146 , A61N1/36185
摘要： Methods, devices and systems are provided to efficiently identify, from among a plurality of possible neurostimulation parameter sets, one or more preferred neurostimulation parameter sets that treat a targeted pain of a patient. A plurality of different neurostimulation parameter sets are tested on the patient to thereby identify those tested neurostimulation parameter sets that treat the targeted pain. Each of the tested neurostimulation parameter sets defines an electrode configuration that differs from the other tested neurostimulation parameter sets. If more than one of the tested neurostimulation parameter sets are identified as treating the targeted pain, then neurostimulation parameter sets identified as treating the targeted pain are retested, with the value for a specific neurostimulation signal parameter reduced by a same amount for each of the retested neurostimulation parameter sets, to thereby identify those neurostimulation parameter sets that treat the targeted pain at the reduced power consumption level.
摘要翻译： 提供了方法，装置和系统以有效地从多个可能的神经刺激参数组中识别治疗患者的目标疼痛的一个或多个优选的神经刺激参数组。 在患者身上测试多个不同的神经刺激参数组，从而识别那些用于治疗目标疼痛的神经刺激参数组。 每个测试的神经刺激参数集定义了与其他测试的神经刺激参数组不同的电极配置。 如果将多于一个测试的神经刺激参数集合识别为治疗目标疼痛，则重新测定被鉴定为治疗目标疼痛的神经刺激参数集，对于每个重新测试的特定神经刺激信号参数的值减少相同的量 神经刺激参数集，从而识别在降低的功耗水平下治疗目标疼痛的神经刺激参数组。
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