-
公开(公告)号：US20050181046A1
公开(公告)日：2005-08-18
申请号：US10700861
申请日：2003-11-04
申请人： Benjamin Oshlack , Curtis Wright , J. Haddox
发明人： Benjamin Oshlack , Curtis Wright , J. Haddox
IPC分类号： A61K9/08 , A61K9/00 , A61K9/02 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/28 , A61K9/48 , A61K9/50 , A61K9/52 , A61K9/54 , A61K9/58 , A61K9/70 , A61K31/135 , A61K31/137 , A61K31/451 , A61K31/46 , A61K31/485 , A61K38/00 , A61K45/06 , A61K45/08 , A61K47/02 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , A61P25/04 , A61P39/00 , A61P43/00 , A61K49/00
CPC分类号： A61K9/5084 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/02 , A61K9/14 , A61K9/1617 , A61K9/1635 , A61K9/1647 , A61K9/1676 , A61K9/1694 , A61K9/2077 , A61K9/2081 , A61K9/2866 , A61K9/4808 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5078 , A61K9/51 , A61K9/7053 , A61K9/7061 , A61K31/485
摘要： Controlled-release dosage forms comprising opioid agonist and opioid antagonist are provided. The dosage forms release the opioid antagonist and the opioid agonist in a controlled-release manner. The dosage forms may be used to provide pain relief to patients while reducing the side effects associated with opioid agonists.
摘要翻译： 提供了包含阿片样物质激动剂和阿片样物质拮抗剂的控制释放剂型。 剂型以控制释放的方式释放阿片样物质拮抗剂和阿片样物质激动剂。 剂型可用于为患者提供疼痛缓解，同时减少与阿片样物质激动剂相关的副作用。
-
公开(公告)号：US20060039970A1
公开(公告)日：2006-02-23
申请号：US10700906
申请日：2003-11-04
申请人： Benjamin Oshlack , Curtis Wright , J. Haddox
发明人： Benjamin Oshlack , Curtis Wright , J. Haddox
CPC分类号： A61K9/5084 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/02 , A61K9/14 , A61K9/1617 , A61K9/1635 , A61K9/1647 , A61K9/1676 , A61K9/1694 , A61K9/2077 , A61K9/2081 , A61K9/2866 , A61K9/4808 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5078 , A61K9/51 , A61K9/7053 , A61K9/7061 , A61K31/485
摘要： Controlled-release dosage forms comprising opioid agonist and opioid antagonist are provided. The dosage forms release the opioid antagonist and the opioid agonist in a controlled-release manner. The dosage forms may be used to provide pain relief to patients while reducing the side effects associated with opioid agonists.
摘要翻译： 提供了包含阿片样物质激动剂和阿片样物质拮抗剂的控制释放剂型。 剂型以控制释放的方式释放阿片样物质拮抗剂和阿片样物质激动剂。 剂型可用于为患者提供疼痛缓解，同时减少与阿片样物质激动剂相关的副作用。
-
公开(公告)号：US20050095291A1
公开(公告)日：2005-05-05
申请号：US10701041
申请日：2003-11-04
申请人： Benjamin Oshlack , Curtis Wright , J. Haddox
发明人： Benjamin Oshlack , Curtis Wright , J. Haddox
IPC分类号： A61K9/08 , A61K9/00 , A61K9/02 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/28 , A61K9/48 , A61K9/50 , A61K9/52 , A61K9/54 , A61K9/58 , A61K9/70 , A61K31/135 , A61K31/137 , A61K31/451 , A61K31/46 , A61K31/485 , A61K38/00 , A61K45/06 , A61K45/08 , A61K47/02 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , A61P25/04 , A61P39/00 , A61P43/00
CPC分类号： A61K9/5084 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/02 , A61K9/14 , A61K9/1617 , A61K9/1635 , A61K9/1647 , A61K9/1676 , A61K9/1694 , A61K9/2077 , A61K9/2081 , A61K9/2866 , A61K9/4808 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5078 , A61K9/51 , A61K9/7053 , A61K9/7061 , A61K31/485
摘要： Disclosed is an oral dosage form comprising (i) an opioid agonist in releasable form and (ii) a sequestered opioid antagonist which is substantially not released when the dosage form is administered intact, such that the ratio of the amount of antagonist released from said dosage form after tampering to the amount of said antagonist released from said intact dosage form is about 4:1 or greater, based on the in-vitro dissolution at 1 hour of said dosage form in 900 ml of Simulated Gastric Fluid using a USP Type II (paddle) apparatus at 75 rpm at 37 degrees C. wherein said agonist and antagonist are interdispersed and are not isolated from each other in two distinct layers.
摘要翻译： 公开了一种口服剂型，其包含（i）可释放形式的阿片样物质激动剂和（ii）隔离的阿片样物质拮抗剂，当所述剂型完全施用时基本上不释放，使得从所述剂量释放的拮抗剂的量的比例 基于在使用USP II型的900ml模拟胃液中的所述剂型在1小时时的体外溶出，篡改之后从所述完整剂型释放的所述拮抗剂的量为约4:1或更大 桨）装置，其在37℃下以75rpm的速度进行，其中所述激动剂和拮抗剂是分散的并且在两个不同的层中不彼此分离。
-
-
搜索结果
3 条记录 (耗时 0.016 秒)
