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公开(公告)号：US08634624B2
公开(公告)日：2014-01-21
申请号：US12760645
申请日：2010-04-15
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , A61B6/037 , G06T5/002 , G06T7/62 , G06T2207/10104 , G06T2207/20104 , G06T2207/30056 , G06T2211/424
摘要： In a methods and apparatus for generating an image for display from medical image data of a subject, image data is processed to reconstruct a pre-image data set, and a filter applied to the pre-image data set to produce a filtered image for display, while a value of a variable is obtained from the pre-image data set, for display with the filtered image. The value obtained from the pre-image data can be used for quantification of a feature of the medical image data.
摘要翻译： 在用于从对象的医学图像数据生成用于显示的图像的方法和装置中，处理图像数据以重构预图像数据集，以及应用于预图像数据集的滤波器以产生用于显示的滤波图像 而从预图像数据集获得变量的值，以便与滤波图像一起显示。 从预图像数据获得的值可以用于量化医学图像数据的特征。
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2.发明授权Method for improving clinical data quality in positron emission tomography 失效正电子发射断层扫描技术提高临床资料质量的方法公开(公告)号：US08058620B2
公开(公告)日：2011-11-15
申请号：US12917701
申请日：2010-11-02
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , G01T7/005
摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data signal-to-noise (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of quantity proportional to SNR, similar in function to SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal dose is then determined and the remainder is injected.
摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供PET数据的处理，以便根据PET扫描仪中的单打率来准确有效地确定与每个单独的临床患者扫描相对应的数据信噪比（SNR）。 该方法将注射剂量与单打率相关联以确定SNR（Dinj），并提供与SNR成比例的量的准确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。 对患者剂量进行分级，最初给予较小的校准剂量。 经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳剂量，并注射剩余部分。
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3.发明申请TIME-OF-FLIGHT (TOF) POSITRON EMISSION TOMOGRAPHY (PET) RECONSTRUCTION FROM TIME-TRUNCATED PROJECTION DATA 有权从时间截断投影数据中的飞行时间（TOF）POSITRON排放测量（PET）重建公开(公告)号：US20090072155A1
公开(公告)日：2009-03-19
申请号：US12212130
申请日：2008-09-17
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , A61B6/037
摘要： A method of TOF-PET image reconstruction using time-truncated TOF-PET projection data. The time-truncated TOF-PET data is obtained by narrowing the scanner time window to a smaller “time window field of view,” which reduces the field of view of a TOF-PET scanner. This results in a lower list mode stream transfer rate, which can be useful in high count rate data acquisitions, in particular 82Rb cardiac studies.
摘要翻译： 使用时间截断的TOF-PET投影数据的TOF-PET图像重建方法。 通过将扫描仪时间窗缩小到更小的“时间窗视野”来获得时间截断的TOF-PET数据，这减少了TOF-PET扫描仪的视场。 这导致较低的列表模式流传输速率，其可用于高计数率数据采集，特别是82Rb心脏研究。
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4.发明申请Method for Improving Clinical Data Quality In Positron Emission Tomography 失效在正电子发射断层扫描中改善临床数据质量的方法公开(公告)号：US20100148047A1
公开(公告)日：2010-06-17
申请号：US12622623
申请日：2009-11-20
CPC分类号： G01T1/2985 , G01T7/005
摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data single-to-noise ratio (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of a quantity proportional to SNR, similar in function to the SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal does is then determined and the remainder injected.
摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供PET数据的处理，以准确且有效地确定与每个单独的临床患者扫描相对应的数据单一噪声比（SNR），作为PET扫描仪中单打率的函数。 该方法将注射剂量与单次速率相关联以确定SNR（Dinj），并且提供与SNR成比例的量的精确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。 对患者剂量进行分级，最初给予较小的校准剂量。 经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳确定并且剩余部分注射。
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5.发明授权Method for improving clinical data quality in positron emission tomography 失效正电子发射断层扫描技术提高临床资料质量的方法公开(公告)号：US07649176B2
公开(公告)日：2010-01-19
申请号：US10987598
申请日：2004-11-12
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , G01T7/005
摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data signal-to-noise ratio (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of a quantity proportional to SNR, similar in function to the SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal dose is then determined and the remainder injected.
摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供了PET数据的处理，以便根据PET扫描仪中的单打率来准确和有效地确定对应于每个单独的临床患者扫描的数据信噪比（SNR）。 该方法将注射剂量与单次速率相关联以确定SNR（Dinj），并且提供与SNR成比例的量的精确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。 对患者剂量进行分级，最初给予较小的校准剂量。 在短时间摄取后，患者被预先扫描以确定T，S和R.然后确定最佳剂量，并注射剩余量。
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6.发明授权Method for improving clinical data quality in positron emission tomography 失效正电子发射断层扫描技术提高临床资料质量的方法公开(公告)号：US07851763B2
公开(公告)日：2010-12-14
申请号：US12622623
申请日：2009-11-20
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , G01T7/005
摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data single-to-noise ratio (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj),and provides an accurate estimate of a quantity proportional to SNR, similar in function to the SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal does is then determined and the remainder injected.
摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供PET数据的处理，以准确且有效地确定与每个单独的临床患者扫描相对应的数据单一噪声比（SNR），作为PET扫描仪中单打率的函数。 该方法将注射剂量与单次速率相关联以确定SNR（Dinj），并且提供与SNR成比例的量的精确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。 对患者剂量进行分级，最初给予较小的校准剂量。 经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳确定并且剩余部分注射。
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7.发明申请Method for improving clinical data quality in positron emission tomography 失效正电子发射断层扫描技术提高临床资料质量的方法公开(公告)号：US20050129170A1
公开(公告)日：2005-06-16
申请号：US10987598
申请日：2004-11-12
申请人： Charles Watson , Michael Casey , Bernard Bendriem
发明人： Charles Watson , Michael Casey , Bernard Bendriem
CPC分类号： G01T1/2985 , G01T7/005
摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data signal-to-noise ratio (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of a quantity proportional to SNR, similar in function to the SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal dose is then determined and the remainder injected.
摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供了PET数据的处理，以便根据PET扫描仪中的单打率来准确和有效地确定对应于每个单独的临床患者扫描的数据信噪比（SNR）。 该方法将注射剂量与单打率相关联以确定SNR（D注射），并且提供与SNR成比例的量的精确估计，其功能类似于SNR（D＆ / SUB>）。 对SNR（D>注）的知识允许确定峰值SNR，最佳剂量，SNR缺陷，剂量缺陷和差异剂量益处。 对患者剂量进行分级，最初给予较小的校准剂量。 在短时间摄取后，患者被预先扫描以确定T，S和R.然后确定最佳剂量，并注射剩余量。
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8.发明申请Method for Improving Clinical Data Quality In Positron Emission Tomography 失效在正电子发射断层扫描中改善临床数据质量的方法公开(公告)号：US20110042572A1
公开(公告)日：2011-02-24
申请号：US12917701
申请日：2010-11-02
IPC分类号： G01T1/20
CPC分类号： G01T1/2985 , G01T7/005
摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data signal-to-noise (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of quantity proportional to SNR, similar in function to SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal dose is then determined and the remainder is injected.
摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供PET数据的处理，以便根据PET扫描仪中的单打率来准确有效地确定与每个单独的临床患者扫描相对应的数据信噪比（SNR）。 该方法将注射剂量与单打率相关联以确定SNR（Dinj），并提供与SNR成比例的量的准确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。 对患者剂量进行分级，最初给予较小的校准剂量。 经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳剂量，并注射剩余部分。
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9.发明授权Time-of-flight (TOF) positron emission tomography (PET) reconstruction from time-truncated projection data 有权从时间截断的投影数据重建飞行时间（TOF）正电子发射断层扫描（PET）重建公开(公告)号：US07737405B2
公开(公告)日：2010-06-15
申请号：US12212130
申请日：2008-09-17
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , A61B6/037
摘要： A method of TOF-PET image reconstruction using time-truncated TOF-PET projection data. The time-truncated TOF-PET data is obtained by narrowing the scanner time window to a smaller “time window field of view,” which reduces the field of view of a TOF-PET scanner. This results in a lower list mode stream transfer rate, which can be useful in high count rate data acquisitions, in particular 82Rb cardiac studies.
摘要翻译： 使用时间截断的TOF-PET投影数据的TOF-PET图像重建方法。 通过将扫描仪时间窗缩小到更小的“时间窗视野”来获得时间截断的TOF-PET数据，这减少了TOF-PET扫描仪的视场。 这导致较低的列表模式流传输速率，其可用于高计数率数据采集，特别是82Rb心脏研究。
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10.发明申请List Mode-Based Respiratory and Cardiac Gating in Positron Emission Tomography 审中-公开基于模式的呼吸和心脏门控正电子发射断层扫描公开(公告)号：US20100067765A1
公开(公告)日：2010-03-18
申请号：US12559721
申请日：2009-09-15
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61B6/037 , A61B6/5217 , A61B6/541
摘要： According to a preferred embodiment, the invention provides a method for extracting internal organ motion from positron emission tomography (PET) coincidence data, the method comprising the following steps: generating a data stream of PET coincidence data using the list mode capability of a PET scanner; dividing the data stream into time frames of a given length; computing a histogram A(i, t) of an axial coincidence distribution for a set of time frames; computing the axial center of mass z(t) for each of the time frames in the set of time frames based on the histogram A(i, t); transforming z(t) into the frequency domain; determining either the frequency contribution caused by respiratory motion, given by fresp, or the frequency contribution caused by heart contractions, given by fcard and Δf, identified in the frequency spectrum |Z(f)|; and carrying out further processing of Z(f) leading to curves zresp(t) and zcard(t) with which a gating sequence is established.
摘要翻译： 根据优选实施例，本发明提供一种从正电子发射断层摄影（PET）符合数据提取内部器官运动的方法，该方法包括以下步骤：使用PET扫描仪的列表模式能力产生PET符合数据的数据流 ; 将数据流划分成给定长度的时间帧; 计算一组时间轴的轴向一致分布的直方图A（i，t）; 基于直方图A（i，t）计算时间帧集合中的每个时间帧的轴向质心z（t）; 将z（t）转换为频域; 确定由fresp给出的呼吸运动引起的频率贡献或由频谱| Z（f）|中确定的fcard和＆Dgr; f给出的由心脏收缩引起的频率贡献; 并进行Z（f）的进一步处理，导致建立门控序列的曲线zresp（t）和zcard（t）。
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