公开(公告)号：US20100148047A1

公开(公告)日：2010-06-17

申请号：US12622623

申请日：2009-11-20

申请人： Bernard Bendriem ,  Michael E. Casey ,  Charles C. Watson

发明人： Bernard Bendriem ,  Michael E. Casey ,  Charles C. Watson

IPC分类号： G01T1/161 ,  G12B13/00

CPC分类号： G01T1/2985 ,  G01T7/005

摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data single-to-noise ratio (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of a quantity proportional to SNR, similar in function to the SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal does is then determined and the remainder injected.

摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供PET数据的处理，以准确且有效地确定与每个单独的临床患者扫描相对应的数据单一噪声比（SNR），作为PET扫描仪中单打率的函数。 该方法将注射剂量与单次速率相关联以确定SNR（Dinj），并且提供与SNR成比例的量的精确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。 对患者剂量进行分级，最初给予较小的校准剂量。 经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳确定并且剩余部分注射。

公开(公告)号：US08058620B2

公开(公告)日：2011-11-15

申请号：US12917701

申请日：2010-11-02

申请人： Bernard Bendriem ,  Michael E. Casey ,  Charles C. Watson

发明人： Bernard Bendriem ,  Michael E. Casey ,  Charles C. Watson

IPC分类号： G01T1/164

CPC分类号： G01T1/2985 ,  G01T7/005

摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data signal-to-noise (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of quantity proportional to SNR, similar in function to SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal dose is then determined and the remainder is injected.

摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供PET数据的处理，以便根据PET扫描仪中的单打率来准确有效地确定与每个单独的临床患者扫描相对应的数据信噪比（SNR）。 该方法将注射剂量与单打率相关联以确定SNR（Dinj），并提供与SNR成比例的量的准确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。 对患者剂量进行分级，最初给予较小的校准剂量。 经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳剂量，并注射剩余部分。

公开(公告)号：US20090072155A1

公开(公告)日：2009-03-19

申请号：US12212130

申请日：2008-09-17

申请人： Charles C. Watson ,  Vladimir Panin ,  Bernard Bendriem ,  Michael E. Casey

发明人： Charles C. Watson ,  Vladimir Panin ,  Bernard Bendriem ,  Michael E. Casey

IPC分类号： G01T1/164

CPC分类号： G01T1/2985 ,  A61B6/037

摘要： A method of TOF-PET image reconstruction using time-truncated TOF-PET projection data. The time-truncated TOF-PET data is obtained by narrowing the scanner time window to a smaller “time window field of view,” which reduces the field of view of a TOF-PET scanner. This results in a lower list mode stream transfer rate, which can be useful in high count rate data acquisitions, in particular 82Rb cardiac studies.

摘要翻译： 使用时间截断的TOF-PET投影数据的TOF-PET图像重建方法。 通过将扫描仪时间窗缩小到更小的“时间窗视野”来获得时间截断的TOF-PET数据，这减少了TOF-PET扫描仪的视场。 这导致较低的列表模式流传输速率，其可用于高计数率数据采集，特别是82Rb心脏研究。

公开(公告)号：US07851763B2

公开(公告)日：2010-12-14

申请号：US12622623

申请日：2009-11-20

申请人： Bernard Bendriem ,  Michael E. Casey ,  Charles C. Watson

发明人： Bernard Bendriem ,  Michael E. Casey ,  Charles C. Watson

IPC分类号： G01T1/164

CPC分类号： G01T1/2985 ,  G01T7/005

摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data single-to-noise ratio (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj),and provides an accurate estimate of a quantity proportional to SNR, similar in function to the SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal does is then determined and the remainder injected.

摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供PET数据的处理，以准确且有效地确定与每个单独的临床患者扫描相对应的数据单一噪声比（SNR），作为PET扫描仪中单打率的函数。 该方法将注射剂量与单次速率相关联以确定SNR（Dinj），并且提供与SNR成比例的量的精确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。 对患者剂量进行分级，最初给予较小的校准剂量。 经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳确定并且剩余部分注射。

公开(公告)号：US20110042572A1

公开(公告)日：2011-02-24

申请号：US12917701

申请日：2010-11-02

申请人： Bernard Bendriem ,  Michael E. Casey ,  Charles C. Watson

发明人： Bernard Bendriem ,  Michael E. Casey ,  Charles C. Watson

IPC分类号： G01T1/20

CPC分类号： G01T1/2985 ,  G01T7/005

摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data signal-to-noise (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of quantity proportional to SNR, similar in function to SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal dose is then determined and the remainder is injected.

摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供PET数据的处理，以便根据PET扫描仪中的单打率来准确有效地确定与每个单独的临床患者扫描相对应的数据信噪比（SNR）。 该方法将注射剂量与单打率相关联以确定SNR（Dinj），并提供与SNR成比例的量的准确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。 对患者剂量进行分级，最初给予较小的校准剂量。 经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳剂量，并注射剩余部分。

公开(公告)号：US07737405B2

公开(公告)日：2010-06-15

申请号：US12212130

申请日：2008-09-17

申请人： Charles C. Watson ,  Vladimir Panin ,  Bernard Bendriem ,  Michael E. Casey

发明人： Charles C. Watson ,  Vladimir Panin ,  Bernard Bendriem ,  Michael E. Casey

IPC分类号： G01T1/164

CPC分类号： G01T1/2985 ,  A61B6/037

摘要： A method of TOF-PET image reconstruction using time-truncated TOF-PET projection data. The time-truncated TOF-PET data is obtained by narrowing the scanner time window to a smaller “time window field of view,” which reduces the field of view of a TOF-PET scanner. This results in a lower list mode stream transfer rate, which can be useful in high count rate data acquisitions, in particular 82Rb cardiac studies.

摘要翻译： 使用时间截断的TOF-PET投影数据的TOF-PET图像重建方法。 通过将扫描仪时间窗缩小到更小的“时间窗视野”来获得时间截断的TOF-PET数据，这减少了TOF-PET扫描仪的视场。 这导致较低的列表模式流传输速率，其可用于高计数率数据采集，特别是82Rb心脏研究。

公开(公告)号：US07649176B2

公开(公告)日：2010-01-19

申请号：US10987598

申请日：2004-11-12

申请人： Charles Watson ,  Michael E. Casey ,  Bernard Bendriem

发明人： Charles Watson ,  Michael E. Casey ,  Bernard Bendriem

IPC分类号： G01T1/164

CPC分类号： G01T1/2985 ,  G01T7/005

摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data signal-to-noise ratio (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of a quantity proportional to SNR, similar in function to the SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal dose is then determined and the remainder injected.

摘要翻译： 一种改善正电子发射断层扫描（PET）临床数据质量的方法。 该方法提供了PET数据的处理，以便根据PET扫描仪中的单打率来准确和有效地确定对应于每个单独的临床患者扫描的数据信噪比（SNR）。 该方法将注射剂量与单次速率相关联以确定SNR（Dinj），并且提供与SNR成比例的量的精确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。 对患者剂量进行分级，最初给予较小的校准剂量。 在短时间摄取后，患者被预先扫描以确定T，S和R.然后确定最佳剂量，并注射剩余量。

公开(公告)号：US06852980B2

公开(公告)日：2005-02-08

申请号：US09982344

申请日：2001-10-18

申请人： William F. Jones ,  Bernard Bendriem ,  Michael E. Casey

发明人： William F. Jones ,  Bernard Bendriem ,  Michael E. Casey

IPC分类号： G01T1/164 ,  G01T1/20 ,  G01T1/29

CPC分类号： G01T1/2985 ,  A61B6/037 ,  A61B6/5205

摘要： A method and apparatus for on-line DOI rebinning for LSO PET/SPECT to improve spatial resolution, for use in a hybrid Positron Emission Tomography (PET)/Single Photon Emission Computed Tomography (SPECT) system running in PET-mode. Data acquisition hardware is used to feed a detector pair coincidence event stream to an on-line rebinner. Gamma centroid location measurements are made by rastering assumed transaxial and radial head positions and the corresponding rebinning maps for optimal back-projected image resolution. Optimal positions are found by collecting a 64-bit list mode file, assuming a crystal position as the centroid for each of the heads, defining a sequence for varying the assumed positions, making the rebinning look-up tables, rebinning the list mode data, histogramming and reconstructing the image, assessing the image resolution, recording the best resolution number and the associated trial position variables, repeating these on the next trial variable set.

摘要翻译： 用于LSO PET / SPECT的在线DOI重组以提高空间分辨率的方法和装置，用于以PET模式运行的混合正电子发射断层扫描（PET）/单光子发射计算机断层扫描（SPECT）系统。 数据采集​​硬件用于将检测器对重合事件流馈送到在线重组器。 伽马重心位置测量是通过对假设的横轴和径向头部位置以及相应的重新组合图进行掠夺来实现最佳背投影图像分辨率。 通过收集64位列表模式文件，假设晶体位置为每个头的质心，定义用于改变假定位置的序列，使重新排列查找表，重新列出列表模式数据，找到最佳位置， 直方图和重建图像，评估图像分辨率，记录最佳分辨率数字和相关联的试验位置变量，在下一个试验变量集中重复这些变量。

公开(公告)号：US06329657B1

公开(公告)日：2001-12-11

申请号：US09070951

申请日：1998-05-01

申请人： Charles C. Watson ,  Ronald Nutt ,  J. Clifton Moyers ,  Michael E. Casey ,  William F. Jones

发明人： Charles C. Watson ,  Ronald Nutt ,  J. Clifton Moyers ,  Michael E. Casey ,  William F. Jones

IPC分类号： G01T1163

CPC分类号： G01T1/2985 ,  A61B6/037

摘要： A coincidence transmission source serves to detect coincident activity from a radiation source. The coincidence transmission source includes a detector dedicated to collecting attenuation data. A collimated radiation source and a detector are positioned with respect to a tomography device such that only a selected strip of the imaging detector of the tomograph is illuminated such that events unrelated to the attenuation are eliminated. The coincidence transmission source includes a collimator in which is disposed a radiation source. An opening is defined by the collimator for exposing a selected portion of the imaging detectors of the tomograph device. Positioned behind the radiation source, relative to the imaging detectors, is the dedicated attenuation detector. The attenuation detector and collimator are designed to illuminate only a strip of the imaging detector, thereby eliminating events not of interest in the attenuation measurement. In a dual head tomograph device, one coincidence transmission source of the present invention is disposed opposite each bank of imaging detectors. The sources and the associated collimators are positioned to the side of each head at a slight angle relative to the respective head. The sources and detectors are fixed relative to the imaging heads. In order to obtain full coverage of the field of view (FOV) in the same manner as for an emission scan, the heads and sources are rotated about the center of the camera.

摘要翻译： 符合传输源用于检测来自辐射源的重合活动。 重合传输源包括专用于收集衰减数据的检测器。 准直辐射源和检测器相对于断层摄影装置定位，使得只有层析成像仪的成像检测器的选定条带被照亮，从而消除与衰减无关的事件。 重合传输源包括其中设置有辐射源的准直仪。 由准直器限定开口以暴露层析成像装置的成像检测器的选定部分。 相对于成像检测器定位在辐射源之后，是专用的衰减检测器。 衰减检测器和准直器被设计为仅照射成像检测器的条带，从而消除衰减测量中不感兴趣的事件。 在双头断层摄影装置中，本发明的一个重合传播源与每一组成像检测器相对设置。 源和相关联的准直仪相对于相应的头部以相当小的角度定位在每个头部的侧面。 源和检测器相对于成像头是固定的。 为了以与发射扫描相同的方式获得视场（FOV）的全面覆盖，头部和源围绕照相机的中心旋转。

公开(公告)号：US07894652B2

公开(公告)日：2011-02-22

申请号：US12110474

申请日：2008-04-28

申请人： Charles H. Hayden, Jr. ,  Michael E. Casey ,  Charles C. Watson

发明人： Charles H. Hayden, Jr. ,  Michael E. Casey ,  Charles C. Watson

IPC分类号： G06K9/00 ,  G01R23/02 ,  G01N23/00

CPC分类号： G01T1/2985 ,  A61B6/037

摘要： A method for correcting PET emission data for prompt gamma emission background components present in non-pure positron-emitting isotopes uses a two component fit of modeled scatter and modeled prompt gamma emission in the area of scatter tails in a normalized emission sinogram. The method allows a PET scan using non-standard PET isotopes to be quantitative and thus more clinically useful.

摘要翻译： 用于校正存在于非纯正电子发射同位素中的迅速γ发射背景分量的PET发射数据的方法使用归一化发射正弦图中散射尾部区域中的建模散射和建模的提示γ发射的双分量拟合。 该方法允许使用非标准PET同位素的PET扫描是定量的，因此在临床上更有用。