公开(公告)号：US4058572A

公开(公告)日：1977-11-15

申请号：US574911

申请日：1975-05-06

申请人： Bernard J. Kane ,  Karen E. Irving ,  James O. Bledsoe, Jr. ,  Levy A. Canova

发明人： Bernard J. Kane ,  Karen E. Irving ,  James O. Bledsoe, Jr. ,  Levy A. Canova

IPC分类号： C07C35/06 ,  C07C29/00 ,  C07C35/08

CPC分类号： C07C35/06

摘要： In a process for hydrogenation, with elemental hydrogen gas in the presence of a hydrogenation catalyst, of a cyclic unsaturated compound having an hydroxyl group projecting from an asymmetric center of the ring and an olefinic carbon-to-carbon double bond which when saturated in the hydrogenation process creates an additional asymmetric center in the ring, the improvement for obtaining increased stereoselectivity by increasing the addition of said hydrogen to that side of the olefin bond on the same side of the compound molecule as said hydroxyl group, comprising: conducting said hydrogenation with a nickel hydrogenation catalyst that has a substantial fraction of its reactive surfaces inactivated.The invention is particularly applicable to the hydrogenation of d-trans-piperitol to d-isomenthol.

摘要翻译： 在氢化催化剂的存在下，使用氢化催化剂中具有羟基的环状不饱和化合物在环的不对称中心突出的氢化方法和烯烃碳 - 碳双键，当在 氢化过程在环中产生另外的不对称中心，通过增加在所述羟基与化合物分子的同一侧向烯烃键的那一侧加入所述氢而获得增加的立体选择性的改进，包括：用所述羟基进行所述氢化 具有大部分反应性表面的镍氢化催化剂失活。