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16 条记录 (耗时 0.013 秒)

    Process for obtaining alpha-campholenic aldehyde
    1.
    发明授权
    Process for obtaining alpha-campholenic aldehyde 失效
    获得α-胆醛醛的方法

    公开(公告)号：US06515186B2

    公开(公告)日：2003-02-04

    申请号：US09850780

    申请日：2001-05-08

    申请人： Bernard J. Kane ,  Gary P. Sanders ,  Joe W. Snow ,  Mark B. Erman

    发明人： Bernard J. Kane ,  Gary P. Sanders ,  Joe W. Snow ,  Mark B. Erman

    IPC分类号： C07C4551

    CPC分类号： C07C45/58 ,  C07C47/225

    摘要： A process for obtaining alpha-campholenic aldehyde, which is useful as an aroma chemical and as a synthetic intermediate for other aroma chemicals, particularly those with a sandalwood odor, and also for some pharmaceuticals, is provided. In particular, the invention includes a continuous process for obtaining optically active or racemic &agr;-campholenic aldehyde by a catalytic rearrangement of optically active or racemic &agr;-pinene oxide that can be commercially practicable. In one embodiment, the method comprises continuously feeding &agr;-pinene oxide to a mixture including catalyst(s) and solvent(s), where the solvent(s) have a boiling point higher than the boiling point of &agr;-campholenic aldehyde, under conditions sufficient to provide for the complete, or at least partial, conversion of &agr;-pinene oxide into &agr;-campholenic aldehyde. The process further includes continuously removing &agr;-campholenic aldehyde from the reaction zone by suitable techniques such as distillation.

    摘要翻译： 提供了一种获得α-胆甾烯醛的方法，其可用作芳香化学物质和用作其它芳香化学品，特别是具有檀香气味的那些的合成中间体，以及用于某些药物。 特别地，本发明包括通过在商业上可行的光学活性或外消旋的α-蒎烯氧化物的催化重排来获得光学活性或外消旋的α-蒎烯醛的连续方法。在一个实施方案中，该方法包括连续进料α-蒎烯 氧化物与包含催化剂和溶剂的混合物，其中溶剂的沸点高于α-蒎烯醛的沸点，条件是足以提供完整的或至少部分的， α-蒎烯氧化物转化成α-camp醛醛。 该方法还包括通过合适的技术例如蒸馏从反应区中连续除去α-蒎烯醛。

    Allylic rearrangement process
    3.
    发明授权
    Allylic rearrangement process 失效
    烯丙基重排过程

    公开(公告)号：US4254291A

    公开(公告)日：1981-03-03

    申请号：US68507

    申请日：1979-08-22

    申请人： Bernard J. Kane

    发明人： Bernard J. Kane

    IPC分类号： C07C29/09 ,  C07C29/12 ,  C07C29/56 ,  C07C29/70 ,  C07C33/02 ,  C07C35/18 ,  C07F5/04

    CPC分类号： C07C29/12 ,  C07C29/095 ,  C07C29/56 ,  C07C29/70 ,  C07B2200/09 ,  C07C2101/16

    摘要： A process for allylic rearrangement, particularly terpenoid allylic rearrangement, utilizing certain acid forming metals to form an ester or alcoholate (alcohologen) of the allylic alcohol to be rearranged, isomerizing and cleaving the alcohologen in the presence of a transition metal compound catalyst and recovering the rearranged alcohol.

    摘要翻译： 一种烯丙基重排方法，特别是萜类烯丙基重排，利用某些形成酸的金属形成待重排的烯丙醇的酯或醇化物（醇解），在过渡金属化合物催化剂的存在下异构化和裂解醇解产物，并回收 重新排列的酒精。

    Cycloheptenols and their derivatives, methods of making thereof, and utilization thereof as fragrances
    5.
    发明授权
    Cycloheptenols and their derivatives, methods of making thereof, and utilization thereof as fragrances 失效
    环庚烯醇及其衍生物，其制备方法和作为香料的利用

    公开(公告)号：US5892104A

    公开(公告)日：1999-04-06

    申请号：US799361

    申请日：1997-02-14

    申请人： Bernard J. Kane ,  Henri M. Hoffmann

    发明人： Bernard J. Kane ,  Henri M. Hoffmann

    IPC分类号： C07C35/20 ,  C07C69/013 ,  C07C69/02 ,  A61K7/46

    CPC分类号： C07C69/013 ,  C07C35/20

    摘要： This invention relates to a compound having the formula I: ##STR1## wherein n is an integer of from 0 to 1; when n is 1, one of dashed lines a and b is a single bond and the other of dashed lines a and b is a double bond, dashed line c is not present, and dashed line d is a single bond; when n is 0, dashed lines a, b, c and d are single bonds or one of dashed lines a and b is a single bond and the other of dashed lines a and b is a double bond, dashed line c is not present, and dashed line d is a double bond; R.sub.1, R.sub.2 and R.sub.3 are, independently, lower branched or straight chain alkyl, alkenyl or alkynyl of C.sub.1 -C.sub.6 ; and R.sub.4 is hydrogen, lower branched or straight chain alkyl, alkenyl or alkynyl of C.sub.1 -C.sub.5, or C(O)R.sub.5, wherein R.sub.5 is hydrogen or lower branched or straight chain alkyl, alkenyl or alkynyl of C.sub.1 -C.sub.4 ; wherein the sum of the carbon atoms in R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is less than or equal to eight carbon atoms. These compounds can be prepared by the cyclization of 1,1,3-trialkyl-1,6-heptadien-3-ols in the presence of an acid. The compounds of formula I are used as fragrance ingredients to confer, enhance, improve, or modify the aroma of a perfumery composition or an article.

    摘要翻译： 本发明涉及具有式I的化合物：其中n为0-1的整数; 当n为1时，虚线a和b之一为单键，虚线a和b中的另一个为双键，虚线c不存在，虚线d为单键; 当n为0时，虚线a，b，c和d为单键，虚线a和b之一为单键，虚线a和b为双键，虚线c不存在， 虚线d为双键; R1，R2和R3独立地为C1-C6的低级支链或直链烷基，烯基或炔基; 且R 4为氢，C 1 -C 5或C（O）R 5的低级支链或直链烷基，烯基或炔基，其中R 5为氢或C 1 -C 4的低级支链或直链烷基，烯基或炔基; 其中R1，R2，R3和R4中的碳原子之和小于或等于8个碳原子。 这些化合物可以通过在酸存在下环化1,1,3-三烷基-1,6-庚二烯-3-醇制备。 式I的化合物用作香料成分以赋予，增强，改善或改变香料组合物或制品的香气。

    Hydrogenation of cyclic unsaturated compounds
    9.
    发明授权
    Hydrogenation of cyclic unsaturated compounds 失效
    环状不饱和化合物的氢化

    公开(公告)号：US4058572A

    公开(公告)日：1977-11-15

    申请号：US574911

    申请日：1975-05-06

    申请人： Bernard J. Kane ,  Karen E. Irving ,  James O. Bledsoe, Jr. ,  Levy A. Canova

    发明人： Bernard J. Kane ,  Karen E. Irving ,  James O. Bledsoe, Jr. ,  Levy A. Canova

    IPC分类号： C07C35/06 ,  C07C29/00 ,  C07C35/08

    CPC分类号： C07C35/06

    摘要： In a process for hydrogenation, with elemental hydrogen gas in the presence of a hydrogenation catalyst, of a cyclic unsaturated compound having an hydroxyl group projecting from an asymmetric center of the ring and an olefinic carbon-to-carbon double bond which when saturated in the hydrogenation process creates an additional asymmetric center in the ring, the improvement for obtaining increased stereoselectivity by increasing the addition of said hydrogen to that side of the olefin bond on the same side of the compound molecule as said hydroxyl group, comprising: conducting said hydrogenation with a nickel hydrogenation catalyst that has a substantial fraction of its reactive surfaces inactivated.The invention is particularly applicable to the hydrogenation of d-trans-piperitol to d-isomenthol.

    摘要翻译： 在氢化催化剂的存在下，使用氢化催化剂中具有羟基的环状不饱和化合物在环的不对称中心突出的氢化方法和烯烃碳 - 碳双键，当在 氢化过程在环中产生另外的不对称中心，通过增加在所述羟基与化合物分子的同一侧向烯烃键的那一侧加入所述氢而获得增加的立体选择性的改进，包括：用所述羟基进行所述氢化 具有大部分反应性表面的镍氢化催化剂失活。