公开(公告)号：US20130005002A1

公开(公告)日：2013-01-03

申请号：US13497985

申请日：2010-09-24

申请人： Bernhard Hauer ,  Thomas Friedrich ,  Rainer Stürmer ,  Nina Schneider ,  Susanne Krauser ,  Wolf-Rüdiger Krahnert

发明人： Bernhard Hauer ,  Thomas Friedrich ,  Rainer Stürmer ,  Nina Schneider ,  Susanne Krauser ,  Wolf-Rüdiger Krahnert

IPC分类号： C12P13/00 ,  C12N9/80

CPC分类号： C12P13/001 ,  C12N9/80 ,  C12P13/04 ,  C12P41/007

摘要： Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which R1 stands for alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or hetaryl, and R2 stands for alkyl, cycloalkyl or aryl, in which an enantiomeric mixture of a simply N-acylated 3-aminocarboxylic acid ester of general formula (I.b), in which R1 and R2 have the meanings given above and R3 stands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim 1.

摘要翻译： 制备通式I的光学活性3-氨基羧酸酯化合物及其铵盐的方法，其中R1代表烷基，烷氧基烷基，烯基，环烷基，杂环烷基，芳基或杂芳基，R2代表烷基，环烷基或 芳基，其中通式（Ib）的简单N-酰化3-氨基羧酸酯的对映体混合物，其中R 1和R 2具有上面给出的含义，R 3代表氢，烷基，环烷基或芳基，被提交到 根据权利要求1的通过加入多肽的对映选择性脱酰作用。