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    Amidase and Use Thereof for Producing 3-Aminocarboxylic Acid Esters
    4.
    发明申请
    Amidase and Use Thereof for Producing 3-Aminocarboxylic Acid Esters 有权
    酰胺酶及其用于生产3-氨基羧酸酯

    公开(公告)号：US20130337512A1

    公开(公告)日：2013-12-19

    申请号：US13942184

    申请日：2013-07-15

    申请人： BASF SE

    发明人： Bernhard Hauer ,  Thomas Friedrich ,  Rainer Stürmer ,  Nina Schneider ,  Susanne Krauser ,  Wolf-Rüdiger Krahnert

    IPC分类号： C12P13/00

    CPC分类号： C12P13/001 ,  C12N9/80 ,  C12P13/04 ,  C12P41/007

    摘要： Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which R1 stands for alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or hetaryl, and R2 stands for alkyl, cycloalkyl or aryl, in which an enantiomeric mixture of a simply N-acylated 3-aminocarboxylic acid ester of general formula (I.b), in which R1 and R2 have the meanings given above and R3 stands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim 1.

    摘要翻译： 制备通式I的光学活性3-氨基羧酸酯化合物及其铵盐的方法，其中R1代表烷基，烷氧基烷基，烯基，环烷基，杂环烷基，芳基或杂芳基，R2代表烷基，环烷基或 芳基，其中通式（Ib）的简单N-酰化3-氨基羧酸酯的对映体混合物，其中R 1和R 2具有上面给出的含义，R 3代表氢，烷基，环烷基或芳基，被提交到 根据权利要求1的通过加入多肽的对映选择性脱酰作用。

    PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED AMINES AND AMIDES BY ENZYMATIC RESOLUTION
    7.
    发明申请
    PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED AMINES AND AMIDES BY ENZYMATIC RESOLUTION 失效
    通过酶分解制备高效的氨基酸和酰胺的方法

    公开(公告)号：US20070298471A1

    公开(公告)日：2007-12-27

    申请号：US11766164

    申请日：2007-06-21

    申请人： Harald Groeger ,  Oliver May ,  Kai Rossen ,  Karlheinz Drauz

    发明人： Harald Groeger ,  Oliver May ,  Kai Rossen ,  Karlheinz Drauz

    IPC分类号： C12P13/00

    CPC分类号： C12P11/00 ,  C12P13/001 ,  C12P13/02 ,  C12P41/007

    摘要： A process for the preparation of an enantiomerically enriched amine, is performed by a) cleaving a racemic mixture of a reaction product of i) a chiral amine and ii) an acyl donor, in the presence of a hydrolase, to obtain a mixture of an enantiomerically enriched amide and an enantiomerically enriched amine; or b) reacting an amine with an acyl donor, in the presence of a hydrolase, to obtain a mixture of an enantiomerically enriched amide and an enantiomerically enriched amine; and c) separating the enantiomerically enriched amide from the enantiomerically enriched amine, wherein the acyl donor is a sulphonylacetic acid ester. The process (1) leads to high enantioselectivities, and (2) high reactivities, (3) is based on an acyl donor accessible in a simple manner, (4) is suitable for a large number of very different substrates and/or (5) is suitable for carrying out at high substrate concentrations.

    摘要翻译： 通过a）在水解酶存在下，将i）手性胺和ii）酰基供体的反应产物的外消旋混合物切割，制备对映体富集的胺的方法，得到 对映异构体富集的酰胺和对映体富集的胺; 或b）在水解酶存在下使胺与酰基供体反应，得到对映体富集的酰胺和对映体富集的胺的混合物; 和c）从对映异构体富集的胺分离对映体富集的酰胺，其中所述酰基供体是磺酰基乙酸酯。 方法（1）导致高对映选择性，和（2）高反应性，（3）基于可以简单方式获得的酰基供体，（4）适用于大量非常不同的底物和/或（5 ）适用于在高底物浓度下进行。

    Process for the Preparation of Alkynols
    8.
    发明申请
    Process for the Preparation of Alkynols 失效
    制备炔醇的方法

    公开(公告)号：US20070276150A1

    公开(公告)日：2007-11-29

    申请号：US10575757

    申请日：2004-10-14

    申请人： Quirinus Broxterman ,  Gerardus Karel Verzijl

    发明人： Quirinus Broxterman ,  Gerardus Karel Verzijl

    IPC分类号： C07F7/02

    CPC分类号： C12P7/04 ,  C07C29/00 ,  C07C29/095 ,  C12P9/00 ,  C12P41/007 ,  C07C33/042

    摘要： Process for the preparation of an alkynol with formula HC═C—C(OH)—R2 (formula 2) wherein R2 represents methyl, halomethyl or ethyl, wherein the corresponding silyl-protected alkynol ester with formula 1 wherein R1 represents H, or an optionally substituted alkyl, an optionally substituted alkenyl or an optionally substituted (hetero)aryl group, R2 is as defined above and A3Si represents a trisubstituted silyl group wherein each A independently represents an optionally substituted alkyl or an optionally substituted (hetero)aryl group, in the presence of water and at least an equivalent amount of amine functionalities is converted into the alkynol with formula 2. Preferably, the amount of water is between 0.5 and 3 equivalents calculated with respect to the amount of silyl-protected alkynol ester with formula (1).

    摘要翻译： 制备具有式HC-CC（OH）-R 2（式2）的炔醇的方法，其中R 2表示甲基，卤代甲基或乙基，其中相应的甲硅烷基 其中R 1表示H，或任选取代的烷基，任选取代的烯基或任选取代的（杂）芳基，R 2是保护的炔醇，其中R 1表示H，或 如上所定义，并且A 3 Si表示三取代的甲硅烷基，其中每个A独立地表示任选取代的烷基或任选取代的（杂）芳基，在水的存在下和至少等量的 胺官能团被转化为具有式2的炔醇。优选地，相对于式（1）的甲硅烷基保护的炔醇酯的量，水的量为0.5-3当量。