公开(公告)号：US4859665A

公开(公告)日：1989-08-22

申请号：US937867

申请日：1986-12-02

申请人： Bernward Garthoff ,  Marcel Gerold ,  Fridolin Hefti ,  Stanislav Kazda ,  Andreas Knorr

发明人： Bernward Garthoff ,  Marcel Gerold ,  Fridolin Hefti ,  Stanislav Kazda ,  Andreas Knorr

IPC分类号： A61K31/50 ,  A61K31/55 ,  A61P9/12

CPC分类号： A61K31/55 ,  Y10S514/929

摘要： Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group consisting of nitro, chlorine and trifluoromethyl, or together with the phenyl ring, the group ##STR2## R.sup.1 is alkyl of 1 to 4 C atoms, which is optionally substituted by alkoxy of 1 to 4 C atoms,R.sup.2 is alkyl of 1 to 12 C atoms, which is optionally substituted by alkoxy of 1 to 3 C atoms, fluorine or N-methyl-N-benzylamino andR.sup.3 is alkyl of 1 to 4 C atoms, cyano or hydroxymethyl, and a pyridazodiazepine of the formula ##STR3## in which R.sup.4 is aralkyl,R.sup.5 is hydrogen or alkyl of 1 to 8 C atoms,R.sup.6 is hydrogen or alkyl of 1 to 8 C atoms andR.sup.7 and R.sup.8 are hydrogen, or together, an oxo group, are described.

摘要翻译： 用于治疗高血压的组合物，其包含有效量的式“IMAGE”的二氢吡啶，其中X是与硝基，氯和三氟甲基相同或不同的取代基，或与苯环一起，组IMA IMA > R 1为1〜4个C原子的烷基，其任选被1〜4个C原子的烷氧基取代，R 2为1〜12个C原子的烷基，其任选被1〜3个C原子的烷氧基取代，氟或N - 甲基-N-苄基氨基，R3为1-4个C原子的烷基，氰基或羟甲基，以及其中R 4为芳烷基，R 5为氢或1至8个C原子的烷基的式“IMAGE”的吡咯并二氮杂为R6 氢或1〜8个碳原子的烷基，R7和R8为氢，或一起为氧代基。