专利检索 ap:("Bert Vogelstein" OR "Kenneth W. Kinzler" OR "Hans Albertsen" OR "Rakesh Anand" OR "Mary Carlson" OR "Joanna Groden" OR "Philip Hedge" OR "Geoff Joslyn" OR "Alexander Fred Markham" OR "Yusuke Nakumura" OR "Andrew Thliveris" OR "Raymond White") AND inv:"Yusuke Nakumura" 第 1 页

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再颁专利
APC antibodies 有权
标题翻译： APC抗体

公开(公告)号：USRE40948E1

公开(公告)日：2009-10-27

申请号：US09983543

申请日：2001-10-24

申请人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakumura , Andrew Thliveris , Raymond White

发明人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakumura , Andrew Thliveris , Raymond White

IPC分类号： C07K16/30 , A61K39/395

摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.

摘要翻译： 公开了一种称为APC的人类基因。提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。这些结果表明APC是肿瘤抑制因子。