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公开(公告)号：USRE40948E1
公开(公告)日：2009-10-27
申请号：US09983543
申请日：2001-10-24
申请人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakumura , Andrew Thliveris , Raymond White
发明人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakumura , Andrew Thliveris , Raymond White
IPC分类号： C07K16/30 , A61K39/395
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译： 公开了一种称为APC的人类基因。 提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。 家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。 这些结果表明APC是肿瘤抑制因子。
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公开(公告)号：USD492197S1
公开(公告)日：2004-06-29
申请号：US29185119
申请日：2003-06-23
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公开(公告)号：USRE36713E
公开(公告)日：2000-05-23
申请号：US726870
申请日：1996-10-04
申请人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertson , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Raymond White
发明人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertson , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Raymond White
CPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in hum tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as wel as in sporadic colorectal cancer patents. APC is expressed in most normal tissue. These results suggest that APC is a tumor suppressor.
摘要翻译： 公开了一种称为APC的人类基因。 提供了方法和试剂盒，用于评估嗡嗡声组织和身体样品中APC基因的突变。 在家族性腺瘤性息肉病患者中发现APC突变与散发性结肠直肠癌专利一样。 APC在大多数正常组织中表达。 这些结果表明APC是肿瘤抑制因子。
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4.发明授权Certain thiazolyl and isothiazolyl compounds and compositions and methods which employ them 失效某些噻唑和异亮氨酸化合物及其组合物及其使用方法
公开(公告)号：US4038408A
公开(公告)日：1977-07-26
申请号：US704871
申请日：1976-07-13
IPC分类号： A61K31/425 , A61K31/426 , A61P9/00 , A61P37/08 , C07D233/64 , C07D277/22 , C07D277/26 , C07D417/00 , C07D275/02
CPC分类号： C07D277/26
摘要： The compounds are heterocyclomethylsulphinylethyl derivatives of N-cyanoguanidines, thioureas and 2-amino-1-nitroethylene which are histamine H.sub.2 -antagonists or are converted into histamine H.sub.2 -antagonists in the animal body. Two specific compounds of the present invention are 1-nitro-2-[2-((2-thiazolyl)methylsulphinyl)ethylamino]-2-[2-((2-thiazolyl)methylthio)ethylamino]ethylene and 1-nitro-2,2-bis-[2-((2-thiazolyl)methylsulphinyl)ethylamino]ethylene.
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公开(公告)号：US3984293A
公开(公告)日：1976-10-05
申请号：US602332
申请日：1975-08-06
IPC分类号： C07D233/54 , C07D233/64 , C25B3/04 , C07D233/14
CPC分类号： C07D233/64 , C25B3/04
摘要： An electrochemical process for preparing 4-(hydroxymethyl)-imidazoles, which are useful as chemical intermediates.
摘要翻译： 用于制备4-（羟甲基） - 咪唑的电化学方法，其可用作化学中间体。
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公开(公告)号：US3979398A
公开(公告)日：1976-09-07
申请号：US627418
申请日：1975-10-30
申请人： George Raymond White
发明人： George Raymond White
IPC分类号： C07D235/06 , C07D237/08 , C07D277/26 , C07D285/12 , C07D213/34
CPC分类号： C07D285/12 , C07D233/64 , C07D235/06 , C07D237/08 , C07D277/26
摘要： The compounds are sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines which are useful to produce inhibition of histamine H-2 receptors.
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公开(公告)号：US20140249530A1
公开(公告)日：2014-09-04
申请号：US14006327
申请日：2012-05-09
申请人： George Babikian , Nick Babikian , Raymond White
发明人： George Babikian , Nick Babikian , Raymond White
IPC分类号： A61B17/82
CPC分类号： A61B17/82 , A61B17/8861 , A61B2017/0046
摘要： The invention is an insertion tool for wrapping an orthopedic wire around a bone. The tool has a memory loop made of memory-shaped material which, when unconstrained, curves to a pre-determined diameter. A push-pull mechanism in the tool body is used to selectively move the memory loop in and out of the tool body. A cutter is provided at the insertion end of the tool body, to cut through tissue close to the bone. When pushed out of the tool body in a direction tangential to the perimeter of a bone, the memory loop automatically curves and wraps around the bone. Orthopedic wire is then attached to the memory loop, which is then pulled back into the tool body, pulling the orthopedic wire around the bone. A cable adapter facilitates coupling any conventional orthopedic wire to the insertion tool.
摘要翻译： 本发明是用于围绕骨包裹矫形线的插入工具。 该工具具有由记忆形状的材料制成的记忆回路，当不受约束时，其曲线到预定直径。 使用工具主体中的推拉机构来选择性地将存储器环路移入和移出工具主体。 切割器设置在工具主体的插入端，以切割靠近骨骼的组织。 当沿与骨周边相切的方向从工具体推出时，记忆回路自动地弯曲并卷绕在骨骼周围。 然后将矫形线连接到记忆回路，然后将其拉回到工具主体中，将矫形线拉到骨头周围。 电缆适配器便于将任何常规矫形线连接到插入工具。
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公开(公告)号：US20080050755A1
公开(公告)日：2008-02-28
申请号：US11725371
申请日：2007-03-19
申请人： Nori Matsunami , Raymond White , Jun Liu
发明人： Nori Matsunami , Raymond White , Jun Liu
IPC分类号： G01N33/53
CPC分类号： G01N33/5011 , A61K38/00
摘要： The present invention provides a method of screening for potential cancer chemotherapeutic and chemopreventive agents which act by inducing or mimicking the activity of Siah-1 in humans. This invention also provides methods of administering such agents to treat cancer by inducing or mimicking the activity of Siah-1, thus causing the degradation of .beta.-catenin.
摘要翻译： 本发明提供了筛选潜在的癌症化学治疗和化学预防剂的方法，其通过诱导或模拟人类中Siah-1的活性而起作用。 本发明还提供了通过诱导或模拟Siah-1的活性来施用此类药物以治疗癌症的方法，从而导致β-连环蛋白的降解。
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公开(公告)号：US20060180478A1
公开(公告)日：2006-08-17
申请号：US11056839
申请日：2005-02-11
申请人： Der-Min Fan , Henry Yeung , Ronald Baron , Damon Gragg , Raymond White , Walter Modic
发明人： Der-Min Fan , Henry Yeung , Ronald Baron , Damon Gragg , Raymond White , Walter Modic
IPC分类号： G01N27/26
CPC分类号： G01N27/49 , G01N27/404
摘要： The invention is a method, system and software application for electrochemical analysis of analytes in a solution. In one aspect of the invention, raw data is received from an electrochemical analysis and the raw data is analyzed. The analyzed data and the raw data are displayed. The electrochemical analysis is performed by applying one or more time-sequenced voltage waveforms in the solution and measuring the resulting current in the solution. In one aspect of the invention, the raw data is received from the electrochemical analysis wherein the raw data is representative of the measured current parameters. The raw data may be integrated based on one or more integration time intervals, and the raw data may be displayed in one or more three dimensional plots. The integrated data and the raw data may also be displayed in one or more two-dimensional plots. The raw data is stored for three dimensional displays and the integrated data is stored for two dimensional displays. Baseline correction is performed on the raw data and the baseline corrected data is displayed in one or more three dimensional plots and in one or more two dimensional plots. The raw data is transmitted and stored at a rate between 100 Hz and 10 KHz.
摘要翻译： 本发明是解决方案中分析物的电化学分析的方法，系统和软件应用。 在本发明的一个方面，从电化学分析接收原始数据，分析原始数据。 显示分析数据和原始数据。 通过在溶液中施加一个或多个时间顺序的电压波形并测量溶液中产生的电流来进行电化学分析。 在本发明的一个方面，从电化学分析接收原始数据，其中原始数据代表所测量的当前参数。 可以基于一个或多个积分时间间隔来整合原始数据，并且原始数据可以显示在一个或多个三维图中。 集成数据和原始数据也可以显示在一个或多个二维图中。 原始数据被存储用于三维显示器，并且集成数据被存储用于二维显示器。 对原始数据进行基线校正，并且在一个或多个三维图和一个或多个二维图中显示基线校正数据。 原始数据以100Hz和10KHz之间的速率传输和存储。
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公开(公告)号：USD492198S1
公开(公告)日：2004-06-29
申请号：US29185128
申请日：2003-06-23
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