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1.发明授权Methods of screening for compounds which bind to a human SNORF36A receptor 失效筛选结合人类SNORF36A受体的化合物的方法公开(公告)号：US06413731B1
公开(公告)日：2002-07-02
申请号：US09518914
申请日：2000-03-03
IPC分类号： G01N3353
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , A61K38/00 , G01N33/567 , G01N2333/726
摘要： This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF36 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF36 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF36 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF36 receptors, methods of isolating mammalian SNORF36 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF36 receptors, as well as methods of determining binding of compounds to mammalian SNORF36 receptors, methods of identifying agonists and antagonists of SNORF36 receptors, and agonists and antagonists so identified.
摘要翻译： 本发明提供编码哺乳动物SNORF36受体的分离的核酸，纯化的哺乳动物SNORF36受体，包含编码哺乳动物SNORF36受体的核酸的载体，包含该载体的细胞，针对哺乳动物SNORF36受体的抗体，用于检测编码哺乳动物SNORF36受体的核酸的核酸探针， 与编码哺乳动物SNORF36受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物SNORF36受体的DNA的转基因非人动物，分离哺乳动物SNORF36受体的方法，治疗与哺乳动物活性相关的异常的方法 SNORF36受体以及确定化合物与哺乳动物SNORF36受体结合的方法，识别SNORF36受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。
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公开(公告)号：US07029914B2
公开(公告)日：2006-04-18
申请号：US10146835
申请日：2002-05-16
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , A61K38/00 , G01N33/567 , G01N2333/726
摘要： This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF36 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF36 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF36 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF36 receptors, methods of isolating mammalian SNORF36 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF36 receptors, as well as methods of determining binding of compounds to mammalian SNORF36 receptors, methods of identifying agonists and antagonists of SNORF36 receptors, and agonists and antagonists so identified.
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公开(公告)号：US07037665B1
公开(公告)日：2006-05-02
申请号：US10018192
申请日：2000-05-03
IPC分类号： G01N33/53
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , A61K38/00 , G01N33/567 , G01N2333/726
摘要： This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF36 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF36 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF36 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF36 receptors, methods of isolating mammalian SNORF36 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF36 receptors, as well as methods of determining binding of compounds to mammalian SNORF36 receptors, methods of identifying agonists and antagonists of SNORF36 receptors, and agonists and antagonists so identified.
摘要翻译： 本发明提供编码哺乳动物SNORF36受体的分离的核酸，纯化的哺乳动物SNORF36受体，包含编码哺乳动物SNORF36受体的核酸的载体，包含该载体的细胞，针对哺乳动物SNORF36受体的抗体，用于检测编码哺乳动物SNORF36受体的核酸的核酸探针， 与编码哺乳动物SNORF36受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物SNORF36受体的DNA的转基因非人动物，分离哺乳动物SNORF36受体的方法，治疗与哺乳动物活性相关的异常的方法 SNORF36受体以及确定化合物与哺乳动物SNORF36受体结合的方法，识别SNORF36受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。
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公开(公告)号：US07517658B2
公开(公告)日：2009-04-14
申请号：US11227855
申请日：2005-09-15
IPC分类号： G01N33/567 , G01N33/53 , C07K14/47
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.
摘要翻译： 本发明提供编码哺乳动物SNORF33受体的分离的核酸，纯化的哺乳动物SNORF33受体，包含编码哺乳动物SNORF33受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF33受体的抗体，用于检测编码哺乳动物SNORF33受体的核酸的核酸探针， 与编码哺乳动物SNORF33受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF33受体的DNA的转基因非人动物，分离哺乳动物SNORF33受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF33受体以及确定化合物与哺乳动物SNORF33受体的结合的方法，识别SNORF33受体的激动剂和拮抗剂的方法，以及所鉴定的激动剂和拮抗剂。
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5.发明授权公开(公告)号：US07371535B2
公开(公告)日：2008-05-13
申请号：US11217710
申请日：2005-09-01
IPC分类号： G01N33/566 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.
摘要翻译： 本发明提供编码哺乳动物SNORF33受体的分离的核酸，纯化的哺乳动物SNORF33受体，包含编码哺乳动物SNORF33受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF33受体的抗体，用于检测编码哺乳动物SNORF33受体的核酸的核酸探针， 与编码哺乳动物SNORF33受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF33受体的DNA的转基因非人动物，分离哺乳动物SNORF33受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF33受体以及确定化合物与哺乳动物SNORF33受体的结合的方法，识别SNORF33受体的激动剂和拮抗剂的方法，以及所鉴定的激动剂和拮抗剂。
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公开(公告)号：US06987005B1
公开(公告)日：2006-01-17
申请号：US09980145
申请日：2000-05-26
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.
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公开(公告)号：US07029857B1
公开(公告)日：2006-04-18
申请号：US09609146
申请日：2000-06-30
CPC分类号： C07K14/70571 , A01K2217/05 , A01K2217/075 , A61K38/00
摘要： This invention provides isolated nucleic acids encoding mammalian SNORF62 and SNORF72 receptors, purified mammalian SNORF62 and SNORF72 receptors, vectors comprising nucleic acid encoding mammalian SNORF62 and SNORF72 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF62 and SNORF72 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF62 and SNORF72 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF62 and SNORF72 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF62 and SNORF72 receptors, methods of isolating mammalian SNORF62 and SNORF72 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF62 and SNORF72 receptors, as well as methods of determining binding of compounds to mammalian SNORF62 and SNORF72 receptors, methods of identifying agonists and antagonists of SNORF62 and SNORF72 receptors, and agonists and antagonists so identified. This invention also provides methods of treating an abnormality that is linked to the activity of a mammalian NMU receptor, as well as methods of determining binding of compounds to mammalian NMU receptors, methods of identifying agonists and antagonists of NMU receptors, and agonists and antagonists so identified.
摘要翻译： 本发明提供编码哺乳动物SNORF62和SNORF72受体的纯化的核酸，纯化的哺乳动物SNORF62和SNORF72受体，包含编码哺乳动物SNORF62和SNORF72受体的核酸的载体，包含该载体的细胞，针对哺乳动物SNORF62和SNORF72受体的抗体， 检测编码哺乳动物SNORF62和SNORF72受体的核酸，与编码哺乳动物SNORF62和SNORF72受体的核酸的唯一序列互补的反义寡核苷酸，其表达编码正常或突变的哺乳动物SNORF62和SNORF72受体的DNA的转基因非人动物，分离哺乳动物SNORF62和SNORF72的方法 受体，治疗与哺乳动物SNORF62和SNORF72受体活性相关的异常的方法，以及确定化合物与哺乳动物SNORF62和SNORF72受体结合的方法，识别SNORF激动剂和拮抗剂的方法 62和SNORF72受体，以及如此鉴定的激动剂和拮抗剂。 本发明还提供了治疗与哺乳动物NMU受体的活性相关的异常的方法，以及确定化合物与哺乳动物NMU受体的结合的方法，鉴定NMU受体的激动剂和拮抗剂的方法，以及激动剂和拮抗剂 确定。
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