公开(公告)号：US07258687B2

公开(公告)日：2007-08-21

申请号：US10538548

申请日：2003-12-11

申请人： Beth Friedman ,  David Kleinfeld ,  Patrick D. Lyden ,  Nozomi Nishimura ,  Christopher B. Schaffer ,  Lee Frederick Schroeder ,  Philbert Tsai

发明人： Beth Friedman ,  David Kleinfeld ,  Patrick D. Lyden ,  Nozomi Nishimura ,  Christopher B. Schaffer ,  Lee Frederick Schroeder ,  Philbert Tsai

IPC分类号： A61B18/20 ,  A61B5/02

CPC分类号： A61B18/20 ,  A61B18/203 ,  A61B2017/00057 ,  A61B2018/00452

摘要： Ultrashort laser pulses are used to induce photodisruptive breakdown in vasculature in an animal to controllably produce hemorrhage, thrombosis or breach of the blood-brain barrier in individual, specifically-targeted blood vessels. Damage is limited to the targeted vessels such that neighboring vessels exhibit no signs of vascular damage, including vessels directly above and directly below the targeted vessel. Ultrashort laser pulses of lower energy are also used to observe and quantify the baseline and altered states of blood flow. Observation and measurement may be performed by TPLSM, OCT or other known techniques, providing a real-time, in vivo model for the dynamics and effects of vascular injury.

摘要翻译： 超短脉冲激光脉冲被用于诱发动物脉管系统中的光破坏性破坏，以可控地产生出血，血栓形成或破坏个体特异性靶向血管中的血脑屏障。 损害局限于目标船只，使相邻船只没有血管损伤迹象，包括直接位于目标船只正下方的血管。 较低能量的超短脉冲激光脉冲也用于观察和定量血流的基线和改变的状态。 观察和测量可以通过TPLSM，OCT或其他已知技术进行，为血管损伤的动力学和影响提供实时的体内模型。