公开(公告)号：US20240316146A1

公开(公告)日：2024-09-26

申请号：US18260677

申请日：2022-01-07

申请人： Bexion Pharmaceuticals Inc.

发明人： Ray Takigiku ,  Darren P. Wolfe ,  Anne Mary Noonan ,  Robert Wesolowski ,  Charles A. Cruze, III ,  Gilles Hugues Tapolsky ,  Richard Charles Curry, III ,  Michael Gazda

IPC分类号： A61K38/17 ,  A61K9/127 ,  A61K31/135 ,  A61K31/137 ,  A61K31/165 ,  A61K31/167 ,  A61K31/192 ,  A61K31/195 ,  A61K31/197 ,  A61K31/282 ,  A61K31/335 ,  A61K31/337 ,  A61K31/381 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/69 ,  A61K31/7048 ,  A61K33/243 ,  A61K38/07 ,  A61K39/395 ,  A61K45/06 ,  A61K47/24 ,  A61P35/00

CPC分类号： A61K38/1709 ,  A61K9/127 ,  A61K31/135 ,  A61K31/137 ,  A61K31/165 ,  A61K31/167 ,  A61K31/192 ,  A61K31/195 ,  A61K31/197 ,  A61K31/282 ,  A61K31/335 ,  A61K31/337 ,  A61K31/381 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/69 ,  A61K31/7048 ,  A61K33/243 ,  A61K38/07 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/24 ,  A61P35/00

摘要： Disclosed herein are methods for reducing neuropathy and neuropathic symptoms and/or promoting neurogenesis, neuritogenesis, neuroprotection and neuroregeneration using saposin C-phospholipid compositions. Also disclosed are methods for treating cancer by administering a saposin C-phospholipid nanovesicle formulation and one or more antineoplastic agents or immune checkpoint inhibitors, and kits for the treatment of cancer comprising, in separate containers, (a) a saposin C-phospholipid pharmaceutical composition, and (b) a pharmaceutical composition containing an antineoplastic agent or a pharmaceutical composition containing an immune checkpoint inhibitor.