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    Cytotoxin compounds and methods of isolation
    1.
    发明授权
    Cytotoxin compounds and methods of isolation 有权
    细胞毒素化合物和分离方法

    公开(公告)号：US08669376B2

    公开(公告)日：2014-03-11

    申请号：US12066938

    申请日：2006-09-18

    申请人： Bill Baker ,  Thushara Diyabalanage ,  James B. McClintock ,  Charles D. Amsler

    发明人： Bill Baker ,  Thushara Diyabalanage ,  James B. McClintock ,  Charles D. Amsler

    IPC分类号： C07D313/00 ,  C12N9/99 ,  A61K31/335 ,  A61P35/00

    CPC分类号： C07D313/00 ,  A61K31/365

    摘要： The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.

    摘要翻译： 本发明涉及来源于Synoicum种的囊泡的化合物组，以及包含这些化合物的药物组合物及其用途。 提取物提取物对NCI60细胞系中几种不同的癌细胞株显示选择性毒性。 这些化合物可用于有效治疗癌症，特别是恶性黑素瘤，结肠癌和肾癌细胞系。

    Cytotoxin Compounds and Methods of Isolation
    2.
    发明申请
    Cytotoxin Compounds and Methods of Isolation 有权
    细胞毒素化合物和分离方法

    公开(公告)号：US20090192215A1

    公开(公告)日：2009-07-30

    申请号：US12066938

    申请日：2006-09-18

    申请人： Bill Baker ,  Thushara Diyabalanage ,  James B. McClintock ,  Charles D. Amsler

    发明人： Bill Baker ,  Thushara Diyabalanage ,  James B. McClintock ,  Charles D. Amsler

    IPC分类号： A61K31/335 ,  C07D313/00 ,  C12N9/99 ,  A61P35/00

    CPC分类号： C07D313/00 ,  A61K31/365

    摘要： The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.

    摘要翻译： 本发明涉及来源于Synoicum种的囊泡的化合物组，以及包含这些化合物的药物组合物及其用途。 提取物提取物对NCI60细胞系中几种不同的癌细胞株显示选择性毒性。 这些化合物可用于有效治疗癌症，特别是恶性黑素瘤，结肠癌和肾癌细胞系。

    System for dynamically constructing an executable computer program
    4.
    发明授权
    System for dynamically constructing an executable computer program 失效
    用于动态构建可执行计算机程序的系统

    公开(公告)号：US07155701B1

    公开(公告)日：2006-12-26

    申请号：US08866744

    申请日：1997-05-30

    申请人： R. Scott Gongwer ,  Joseph J. Tamburino ,  Kurt Larson ,  Bill Baker

    发明人： R. Scott Gongwer ,  Joseph J. Tamburino ,  Kurt Larson ,  Bill Baker

    IPC分类号： G06F17/30 ,  G06F9/44

    CPC分类号： G06F9/44521 ,  G06F9/4486 ,  Y10S707/99944

    摘要： An executable computer program is dynamically constructed by tightly coupling a plurality of dynamically loadable modules. Each modules includes a fully encapsulated function which is typically called from another module. A registration system is employed to associate a pointer with each defined function. In the modules, at run time, each function call is resolved using the associated pointer from the registration system. In particular, each function call is dereferenced by the associated pointer. Consequently, the resulting executable computer program is both flexible and efficient.

    摘要翻译： 可执行计算机程序通过紧密耦合多个可动态加载的模块来动态构建。 每个模块包括一个完全封装的功能，通常从另一个模块调用。 使用注册系统将指针与每个定义的功能相关联。 在模块中，在运行时，使用与注册系统相关联的指针来解析每个函数调用。 特别地，每个函数调用由相关联的指针解引用。 因此，所得到的可执行计算机程序既灵活又高效。

    Compound phase encoding for printed servo patterns
    5.
    发明申请
    Compound phase encoding for printed servo patterns 失效
    打印伺服模式的复合相位编码

    公开(公告)号：US20050259341A1

    公开(公告)日：2005-11-24

    申请号：US10519440

    申请日：2003-12-31

    申请人： Bill Baker

    发明人： Bill Baker

    IPC分类号： G11B5/09 ,  G11B5/584 ,  G11B5/596 ,  G11B5/86

    CPC分类号： B82Y10/00 ,  G11B5/584 ,  G11B5/59633 ,  G11B5/5965 ,  G11B5/743 ,  G11B5/865

    摘要： A type of servo pattern suitable for tracking systems in magnetic recording devices such as floppy disks or linear tape or thin hard disks or in other machines. The pattern comprises several phase-encoded elements that provide an absolute transverse position coordinate from local data. Computations can be made with channel chips commonly used in magnetic recording disk drives.

    摘要翻译： 一种适用于跟踪诸如软盘或线性磁带或薄型硬盘或其他机器的磁记录装置中的系统的伺服模式。 该图案包括几个相位编码的元件，它们提供从本地数据的绝对横向位置坐标。 可以使用通常用于磁记录磁盘驱动器的通道芯片进行计算。

    Self-writing of servo patterns in disk drives
    7.
    发明授权
    Self-writing of servo patterns in disk drives 有权
    在磁盘驱动器中自动写入伺服模式

    公开(公告)号：US06738205B1

    公开(公告)日：2004-05-18

    申请号：US09903445

    申请日：2001-07-08

    申请人： Patrick Moran ,  Tim Everett ,  Peter McEwen ,  Mike Moser ,  Stan Shepherd ,  Eduardo Gentile Veiga ,  Murat Erkocevic ,  Bill Baker

    发明人： Patrick Moran ,  Tim Everett ,  Peter McEwen ,  Mike Moser ,  Stan Shepherd ,  Eduardo Gentile Veiga ,  Murat Erkocevic ,  Bill Baker

    IPC分类号： G11B586

    CPC分类号： G11B5/865 ,  G11B5/59633

    摘要： A method and system for self-servo writing a disk drive by transferring a servo reference pattern by magnetic printing onto at least one storage surface of a reference disk, wherein a resulting printed reference pattern includes embedded servo information providing servo timing and transducer head position information; assembling the disk drive including the steps of installing at least said disk into the disk drive and enclosing said disk and the data transducers within a housing sealed against particulate contamination from an eternal ambient environment; reading the printed reference pattern from said disk via at least one transducer head to generate a readback signal; sampling the readback signal at a sampling rate to generate a sampled signal; processing the sampled signal waveform specturm to generate a recovered signal including the embedded servo information and a fundamental frequency of the sampled signal; using the servo information from the recovered signal to precisely position and maintain the data transducers at concentric track locations of disk storage surfaces; and self-writing disk drive servo patterns onto the storage surfaces at the concentric track locations with the data transducers in accordance with disk drive servo pattern features.

    摘要翻译： 一种用于通过磁性印刷将伺服参考图案转移到参考盘的至少一个存储表面上来自动伺服写入磁盘驱动器的方法和系统，其中所得到的打印参考图案包括提供伺服定时和换能器头部位置信息的嵌入式伺服信息 ; 组装磁盘驱动器包括以下步骤：至少将所述磁盘安装到磁盘驱动器中，并将所述磁盘和数据传感器封装在壳体内，密封以防止来自永恒环境环境的颗粒污染物; 经由至少一个换能器头从所述盘读取打印的参考图案以产生回读信号; 以采样率对回读信号进行采样以产生采样信号; 处理采样信号波形谱以产生包括嵌入伺服信息和采样信号的基频的恢复信号; 使用来自恢复信号的伺服信息来精确地将数据传感器定位并保持在盘存储表面的同心轨迹位置; 以及根据磁盘驱动器伺服模式特征，使用数据传感器在同心轨道位置的存储表面上自写盘驱动器伺服模式。

    Cytotoxin Compound and Method of Isolation
    9.
    发明申请
    Cytotoxin Compound and Method of Isolation 有权
    细胞毒素化合物及其分离方法

    公开(公告)号：US20050187286A1

    公开(公告)日：2005-08-25

    申请号：US10906386

    申请日：2005-02-17

    申请人： Bill Baker ,  Thusahara Diyabalanage ,  James McClintock ,  Charles Amsler

    发明人： Bill Baker ,  Thusahara Diyabalanage ,  James McClintock ,  Charles Amsler

    IPC分类号： A61K31/335 ,  A61K31/365 ,  A61K35/56 ,  C07D315/00 ,  A61K35/12

    CPC分类号： C07D313/00 ,  A61K31/365

    摘要： A compound or groups of compounds, present in an active principle, derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.

    摘要翻译： 存在于活性成分中的化合物或一组化合物，衍生自物种Syncopum conareumum的囊泡，以及包含这些化合物的药物组合物。 提取物提取物对NCI60细胞系中几种不同的癌细胞株显示选择性毒性。 这些化合物可用于有效治疗癌症，特别是恶性黑素瘤，结肠癌和肾癌细胞系。

    Self-writing of servo patterns in a disk drive using a printed reference pattern
    10.
    发明授权
    Self-writing of servo patterns in a disk drive using a printed reference pattern 失效
    使用打印的参考图案在磁盘驱动器中自动写入伺服模式

    公开(公告)号：US06704156B1

    公开(公告)日：2004-03-09

    申请号：US09494826

    申请日：2000-01-31

    申请人： Bill Baker ,  Michael Mayo

    发明人： Bill Baker ,  Michael Mayo

    IPC分类号： G11B2102

    CPC分类号： G11B5/59633 ,  G11B5/865

    摘要： A method for self-servo writing a disk drive includes the steps of transferring a servo reference pattern by magnetic printing onto at least one storage surface of a disk; assembling the disk drive including installing the disk into the disk drive and enclosing the disk and the data transducers within a housing sealed against particulate contamination from an eternal ambient environment; reading the servo reference pattern from the disk via transducer heads; using head position and timing information in the pattern to precisely position and maintain the data transducers at concentric track locations of disk storage surfaces; and self-writing disk drive servo patterns onto the storage surfaces at the concentric track locations with the data transducers in accordance with the disk drive servo pattern features. In one example, the reference pattern includes servo clock information providing transducer head circumferential relative position information, and a servo position information pattern having coarse position information for providing transducer head coarse radial relative position information, and fine position information for providing transducer head fine radial relative position information. The printed reference pattern features have a resolution lower than a disk drive servo pattern features proportional to head gap widths of data transducer heads included in the disk drive.

    摘要翻译： 一种用于自动伺服写入磁盘驱动器的方法包括以下步骤：通过磁性印刷将伺服参考图案传送到盘的至少一个存储表面; 组装磁盘驱动器，包括将磁盘安装到磁盘驱动器中并将磁盘和数据传感器封装在外壳内，密封以防止来自永恒周围环境的颗粒污染; 通过换能器头从盘读取伺服参考模式; 使用图案中的头位置和时间信息来精确地将数据传感器定位并保持在盘存储表面的同心轨道位置; 以及根据磁盘驱动器伺服模式特征，使用数据传感器在同心轨道位置的存储表面上自写盘驱动器伺服模式。 在一个示例中，参考图案包括提供换能器头周向相对位置信息的伺服时钟信息，以及具有用于提供换能器头部粗略径向相对位置信息的粗略位置信息的伺服位置信息模式，以及用于提供换能器头精细径向相对位置的精细位置信息 位置信息。 打印的参考图案特征的分辨率低于磁盘驱动器伺服模式的特征，与磁盘驱动器中包括的数据传感器头的磁头间隙宽度成比例。