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公开(公告)号:US20070185092A1
公开(公告)日:2007-08-09
申请号:US11620615
申请日:2007-01-05
申请人: Bing-Yan Zhu , Shawn Bauer , Zhaozhong Jia , Yonghong Song , Gary Probst , Yanchen Zhang , Robert Scarborough
发明人: Bing-Yan Zhu , Shawn Bauer , Zhaozhong Jia , Yonghong Song , Gary Probst , Yanchen Zhang , Robert Scarborough
IPC分类号: A61K31/551 , A61K31/502 , A61K31/513 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/4439 , C07D409/14
CPC分类号: C07D409/14 , C07D333/38 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式(I)表示的化合物或其药学上可接受的盐,酯或前药,其是因子Xa的抑制剂。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号:US20060100193A1
公开(公告)日:2006-05-11
申请号:US11158274
申请日:2005-06-20
申请人: Bing-Yan Zhu , Shawn Bauer , Zhaozhong Jia , Gary Probst , Yanchen Zhang , Robert Scarborough
发明人: Bing-Yan Zhu , Shawn Bauer , Zhaozhong Jia , Gary Probst , Yanchen Zhang , Robert Scarborough
IPC分类号: A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/453 , A61K31/4745 , A61K31/422 , A61K31/397 , A61K31/381 , C07D413/02 , C07D409/02
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
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公开(公告)号:US20050107357A1
公开(公告)日:2005-05-19
申请号:US10956004
申请日:2004-09-29
申请人: Robert Scarborough , Wolin Huang , Anjali Pandey , Shawn Bauer , Xiaoming Zhang , Zhaozhong Jia
发明人: Robert Scarborough , Wolin Huang , Anjali Pandey , Shawn Bauer , Xiaoming Zhang , Zhaozhong Jia
IPC分类号: A61K20060101 , A61K31/517 , A61P7/02 , C07D409/12 , C07D409/14 , C07D49/14
CPC分类号: C07D409/12 , C07D409/14
摘要: 2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
摘要翻译: 提供2,4-二氧代-3-喹唑啉基芳基磺酰脲化合物,其可用于抑制ADP-血小板聚集,特别是在治疗血栓形成和血栓形成相关病症或病症中。
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公开(公告)号:US20120101275A1
公开(公告)日:2012-04-26
申请号:US13275253
申请日:2011-10-17
申请人: Zhaozhong Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrotra , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
发明人: Zhaozhong Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrotra , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
IPC分类号: C07D403/12
CPC分类号: A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要翻译: 本发明涉及作为syk激酶抑制剂的式I-V化合物及其互变异构体或其药学上可接受的盐,酯和前药。 本发明还涉及用于制备这种化合物的中间体,这种化合物的制备,含有这种化合物的药物组合物,抑制syk激酶活性的方法,抑制血小板聚集的方法,以及预防或治疗数字的方法 至少部分通过syk激酶活性介导的病症,例如不期望的血栓形成和非霍奇金淋巴瘤。
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公开(公告)号:US20100048567A1
公开(公告)日:2010-02-25
申请号:US12386525
申请日:2009-04-16
申请人: Zhaozhong Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrota , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
发明人: Zhaozhong Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrota , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
IPC分类号: A61K31/5377 , C07D239/02 , C07D413/02 , C07D403/02 , A61K31/497 , A61K31/505 , A61K31/506 , C12N5/02
CPC分类号: A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要翻译: 本发明涉及作为syk激酶抑制剂的式I-V化合物及其互变异构体或其药学上可接受的盐,酯和前药。 本发明还涉及用于制备这种化合物的中间体,这种化合物的制备,含有这种化合物的药物组合物,抑制syk激酶活性的方法,抑制血小板聚集的方法,以及预防或治疗数字的方法 至少部分通过syk激酶活性介导的病症,例如不期望的血栓形成和非霍奇金淋巴瘤。
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公开(公告)号:US20120130073A1
公开(公告)日:2012-05-24
申请号:US13269523
申请日:2011-10-07
申请人: Zhaozhong Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrotra , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
发明人: Zhaozhong Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrotra , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
IPC分类号: C07D403/12
CPC分类号: A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
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