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公开(公告)号：US20230101131A1
公开(公告)日：2023-03-30
申请号：US17837929
申请日：2022-06-10
发明人： Yong Moon CHOI
IPC分类号： C07C271/16
摘要： The present invention relates to a crystalline form of a phenyl carbamate derivative compound and a use thereof, and more particularly, to a more thermodynamically stable crystal, i.e., a Pattern 1 crystalline form, and a preparation method thereof. Amorphous and crystalline forms were prepared using various solvents, and among these, a thermodynamically stable Pattern 1 crystalline form and a pharmaceutical use of this crystalline form are provided.
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2.发明申请公开(公告)号：US20220062220A1
公开(公告)日：2022-03-03
申请号：US17461695
申请日：2021-08-30
发明人： Yong Moon CHOI
摘要： The present invention relates to a phenyl alkyl carbamate compound for use in preventing or treating neurodegenerative diseases. The phenyl alkyl carbamate compound of the present invention, prevented dopaminergic neuron loss, attenuated activation of astrocyte/microglia, repressed phosphorylated alpha-synuclein, and regulated phosphorylation levels of tau and acetylation levels of alpha-tubulin in the Parkinson's disease animal model. In addition, the phenyl alkyl carbamate compound of the present invention reduced the Amyloid-beta precursor protein and Amyloid-beta. Therefore, the phenyl alkyl carbamate compound of the present invention may be effectively used for preventing or treating neurodegenerative diseases.
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公开(公告)号：US20230286910A1
公开(公告)日：2023-09-14
申请号：US18185830
申请日：2023-03-17
发明人： Yong Moon CHOI
IPC分类号： C07C271/12
CPC分类号： C07C271/12 , C07B2200/13
摘要： The present invention relates to crystalline forms of a phenyl carbamate derivative compound and compositions and uses thereof.
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公开(公告)号：US20220218702A1
公开(公告)日：2022-07-14
申请号：US16980822
申请日：2020-09-10
发明人： Yong Moon CHOI
IPC分类号： A61K31/506 , A61K31/357 , A61K31/427 , A61K31/381 , A61K31/443 , A61P25/24
摘要： The present invention relates to a pharmaceutical composition for treating and/or alleviating a psychiatric disorder comprising a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a pharmaceutical composition for inducing anti-stress, anti-anxiety and/or anti-depressant activities comprising a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient.
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公开(公告)号：US20180230090A1
公开(公告)日：2018-08-16
申请号：US15516133
申请日：2017-02-28
发明人： Yong Moon CHOI
IPC分类号： C07C307/02 , C07D213/61 , C07D277/32 , C07D277/24 , C07D333/16 , A61P25/08
CPC分类号： C07C307/02 , A61P25/08 , A61P25/18 , C07C2601/02 , C07D213/46 , C07D213/61 , C07D277/24 , C07D277/32 , C07D333/16
摘要： The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a sulfamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention CNS disorders comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of CNS disorders.
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公开(公告)号：US20240076265A1
公开(公告)日：2024-03-07
申请号：US18500742
申请日：2023-11-02
发明人： Yong Moon CHOI
IPC分类号： C07C271/12
CPC分类号： C07C271/12 , C07B2200/13
摘要： The present invention relates to crystalline forms of a phenyl carbamate derivative compound and compositions and uses thereof.
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公开(公告)号：US20180057449A1
公开(公告)日：2018-03-01
申请号：US15526502
申请日：2017-02-28
发明人： Yong Moon CHOI
IPC分类号： C07C271/34
CPC分类号： C07C271/34 , C07C35/32 , C07C35/52 , C07C43/192 , C07C2602/08 , C07C2602/10 , C07F7/1804
摘要： The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a carbamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention CNS disorders comprising administering a carbamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of CNS disorders.
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8.发明申请PHENYL ALKYL CARBAMATE COMPOUNDS FOR USE IN PREVENTING OR TREATING EPILEPSY OR EPILEPSY-RELATED SYNDROME 有权用于预防或治疗脓毒症或与性病相关的综合征的苯甲酸亚苄酯化合物公开(公告)号：US20160023999A1
公开(公告)日：2016-01-28
申请号：US14774287
申请日：2014-03-11
发明人： Yong Moon CHOI
IPC分类号： C07C271/12 , C07C271/24
CPC分类号： A61K31/325 , A61K31/03 , A61K31/27 , C07C271/12 , C07C271/24 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/42
摘要： The present invention provides a pharmaceutical composition for preventing and/or treating a epilepsy or epilepsy-related syndrome, for example an intractable epilepsy or its related syndrome such as drug-resistant epilepsy, comprising the phenyl alkyl carbamate compound as an active ingredient, and a use of the phenyl alkyl carbamate compound for preventing and/or treating epilepsy or epilepsy-related syndrome.
摘要翻译： 本发明提供了用于预防和/或治疗癫痫或癫痫相关综合征的药物组合物，例如顽固性癫痫或其相关综合征，例如耐药性癫痫，其包含苯基烷基氨基甲酸酯化合物作为活性成分，以及 使用苯基烷基氨基甲酸酯化合物来预防和/或治疗癫痫或癫痫相关综合征。
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