公开(公告)号：US12109194B2

公开(公告)日：2024-10-08

申请号：US17684279

申请日：2022-03-01

申请人： BioJiva LLC

发明人： Peter Milner ,  Nadia Litterman ,  Mark Midei

IPC分类号： A61K31/4152 ,  A61K31/202 ,  A61P25/28

CPC分类号： A61K31/4152 ,  A61K31/202 ,  A61P25/28

摘要： Disclosed are methods for inhibiting the progression of amyotrophic lateral sclerosis (ALS) in humans. The methods use a synergistic combination of 3-methyl-1-phenyl-2-pyrazoline-5-one and deuterated arachidonic acid or a prodrug thereof, such as 11,11-D2-linoleic acid or an ester thereof.

公开(公告)号：US20230165824A1

公开(公告)日：2023-06-01

申请号：US17902684

申请日：2022-09-02

申请人： BioJiva LLC

发明人： Peter Milner ,  Mikhail Sergeevich Schepinov

IPC分类号： A61K31/202 ,  A61P43/00

CPC分类号： A61K31/202 ,  A61P43/00

摘要： Disclosed are methods for treatment of neurodegenerative diseases or inhibiting the progression of neurodegenerative disease. The methods may comprise inhibiting cellular dysfunctionality and subsequent cell death due to cellular accumulation of oxidized polyunsaturated fatty acids (PUFAs) products wherein said accumulation is mediated, at least in part, by impaired enzymatic process(es) that are responsible for neutralizing said oxidized products. The methods include administering to a patient suffering from such a disease a composition comprising either deuterated arachidonic acid or a prodrug thereof. In some embodiments, these methods treat neurodegenerative diseases mediated by intracellular concentrations of 15-hydroperoxy-(Hp)-arachidonoyl-phophatidylethanolamine (15-HpETE-PE) by limiting the generation of this neurotoxin.