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公开(公告)号：US20230333087A1
公开(公告)日：2023-10-19
申请号：US18167781
申请日：2023-02-10
申请人： BioJiva LLC
IPC分类号： G01N33/50
CPC分类号： G01N33/5008
摘要： Disclosed are methods for assessing the presence or absence of a therapeutic concentration of a deuterated docosahexaenoic acid during treatment of a patient with a retinal oxidative disease.
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公开(公告)号：US12109194B2
公开(公告)日：2024-10-08
申请号：US17684279
申请日：2022-03-01
申请人： BioJiva LLC
发明人： Peter Milner , Nadia Litterman , Mark Midei
IPC分类号： A61K31/4152 , A61K31/202 , A61P25/28
CPC分类号： A61K31/4152 , A61K31/202 , A61P25/28
摘要： Disclosed are methods for inhibiting the progression of amyotrophic lateral sclerosis (ALS) in humans. The methods use a synergistic combination of 3-methyl-1-phenyl-2-pyrazoline-5-one and deuterated arachidonic acid or a prodrug thereof, such as 11,11-D2-linoleic acid or an ester thereof.
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3.发明公开公开(公告)号：US20230165824A1
公开(公告)日：2023-06-01
申请号：US17902684
申请日：2022-09-02
申请人： BioJiva LLC
IPC分类号： A61K31/202 , A61P43/00
CPC分类号： A61K31/202 , A61P43/00
摘要： Disclosed are methods for treatment of neurodegenerative diseases or inhibiting the progression of neurodegenerative disease. The methods may comprise inhibiting cellular dysfunctionality and subsequent cell death due to cellular accumulation of oxidized polyunsaturated fatty acids (PUFAs) products wherein said accumulation is mediated, at least in part, by impaired enzymatic process(es) that are responsible for neutralizing said oxidized products. The methods include administering to a patient suffering from such a disease a composition comprising either deuterated arachidonic acid or a prodrug thereof. In some embodiments, these methods treat neurodegenerative diseases mediated by intracellular concentrations of 15-hydroperoxy-(Hp)-arachidonoyl-phophatidylethanolamine (15-HpETE-PE) by limiting the generation of this neurotoxin.
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4.发明授权公开(公告)号：US11779910B2
公开(公告)日：2023-10-10
申请号：US17180634
申请日：2021-02-19
申请人： BioJiva LLC
CPC分类号： B01J31/1616 , B01J31/2295 , C07B59/001 , C11C3/00 , B01J2231/40 , B01J2531/821 , C07B2200/05
摘要： Disclosed herein are methods for preparing isotopically modified polyunsaturated lipids containing 1,4-diene systems involving selective isotopic modification of one or more bis-allylic positions of the polyunsaturated lipids in the presence of a transition metal catalyst.
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公开(公告)号：US20230255917A1
公开(公告)日：2023-08-17
申请号：US17949713
申请日：2022-09-21
申请人： BioJiva LLC
IPC分类号： A61K31/202 , A61P25/28 , A61K31/232
CPC分类号： A61K31/202 , A61P25/28 , A61K31/232
摘要： Disclosed are methods for inhibiting the progression of neurodegenerative disease. The methods include administering to a patient suffering from such a disease a composition comprising either deuterated linoleic acid or an ester thereof.
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公开(公告)号：US12060324B2
公开(公告)日：2024-08-13
申请号：US17884959
申请日：2022-08-10
申请人： BioJiva LLC
IPC分类号： C07C67/30 , A61P1/16 , C07B59/00 , C07C5/00 , C07C11/12 , C07C29/00 , C07C51/347 , C07C69/587 , C07C407/00
CPC分类号： C07C67/30 , C07B59/001 , C07C5/00 , C07C11/12 , C07C29/00 , C07C51/347 , C07C69/587 , C07C407/00 , A61P1/16 , B01J2531/822 , C07B2200/05 , C07C2523/46 , C07C2531/22 , C07C2531/24 , C07C407/00 , C07C409/16 , C07C67/30 , C07C69/587 , C07C29/00 , C07C33/02 , C07C5/00 , C07C11/21
摘要： Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.
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公开(公告)号：US20240238238A1
公开(公告)日：2024-07-18
申请号：US18621682
申请日：2024-03-29
申请人： BioJiva LLC
IPC分类号： A61K31/231 , A61K31/201 , A61P25/28
CPC分类号： A61K31/231 , A61K31/201 , A61P25/28
摘要： Isotopically modified polyunsaturated fatty acid or ester thereof, such as 11,11-D2-linoleic acid or its ethyl ester, and uses of the same for treating or ameliorating the symptoms of Friedreich's ataxia are disclosed.
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公开(公告)号：US20240018085A1
公开(公告)日：2024-01-18
申请号：US17884959
申请日：2022-08-10
申请人： BioJiva LLC
IPC分类号： C07C67/30 , C07C5/00 , C07C407/00 , C07C29/00 , C07B59/00 , C07C69/587 , C07C51/347 , C07C11/12
CPC分类号： C07C67/30 , C07C5/00 , C07C407/00 , C07C29/00 , C07B59/001 , C07C69/587 , C07C51/347 , C07C11/12 , C07B2200/05 , C07C2523/46 , C07C2531/22 , C07C2531/24 , A61P1/16
摘要： Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.
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9.发明公开公开(公告)号：US20240091752A1
公开(公告)日：2024-03-21
申请号：US18244347
申请日：2023-09-11
申请人： BioJiva LLC
CPC分类号： B01J31/1616 , B01J31/2295 , C07B59/001 , C11C3/00 , B01J2231/40 , B01J2531/821 , C07B2200/05
摘要： Disclosed herein are methods for preparing isotopically modified polyunsaturated lipids containing 1,4-diene systems involving selective isotopic modification of one or more bis-allylic positions of the polyunsaturated lipids in the presence of a transition metal catalyst.
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公开(公告)号：US20240091187A1
公开(公告)日：2024-03-21
申请号：US18167783
申请日：2023-02-10
申请人： BioJiva LLC
IPC分类号： A61K31/202 , A61P27/02 , G01N33/92
CPC分类号： A61K31/202 , A61P27/02 , G01N33/92
摘要： Disclosed are methods for assessing the presence or absence of a therapeutic concentration of a deuterated docosahexaenoic acid during treatment of a patient with a retinal or neuronal oxidative disease.
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