公开(公告)号：US20240041999A1

公开(公告)日：2024-02-08

申请号：US18258343

申请日：2021-12-20

Applicant: BioNTech SE

Inventor： Mathias Vormehr ,  Lena Mareen Kranz ,  Ugur Sahin ,  David Eisel

IPC: A61K39/00 ,  A61P37/02

CPC classification number: A61K39/001111 ,  A61P37/02 ,  A61K2039/53 ,  A61K2039/55533 ,  A61K2039/55555 ,  A61K2039/545

Abstract: This disclosure relates to the field of therapeutic RNA to treat cancer. Disclosed herein are compositions, uses, and methods for treatment of cancers Administration of therapeutic RNAs to a patient having cancer disclosed herein can reduce tumor size, prolong time to progressive disease, and/or protect against metastasis and/or recurrence of the tumor and ultimately extend survival time.