公开(公告)号：US20240263232A1

公开(公告)日：2024-08-08

申请号：US18420361

申请日：2024-01-23

Applicant: BioNTech SE

Inventor： Ugur SAHIN ,  Martin SUCHAN ,  Barbara SCHRÖRS ,  Martin LÖWER ,  Petra OEHM

IPC: C12Q1/6876 ,  C12Q1/686

CPC classification number: C12Q1/6876 ,  C12Q1/686 ,  C12Q2600/156

Abstract: This invention relates to methods for screening for a genotype for loss of antigen presentation via MHC class I in a subject and/or respectively detecting a subject's increased risk of resistance against immunotherapy such as against vaccination.

公开(公告)号：US20250025505A1

公开(公告)日：2025-01-23

申请号：US18717782

申请日：2022-12-08

Applicant: BioNTech SE

Inventor： Ugur SAHIN ,  Petra OEHM ,  Benjamin RENGSTL ,  Katharina REINHARD ,  Liane Monika PREUSSNER ,  Özlem TÜRECI

IPC: A61K35/17 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7105 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28 ,  C12N5/0783

Abstract: The present disclosure relates to chimeric antigen receptor (CAR) expressing immune effector cells showing highly specific and sensitive recognition of CLDN6 expressing cancer cells as well as a high potential for treating cancer in humans.