公开(公告)号：US20240124609A1

公开(公告)日：2024-04-18

申请号：US18363136

申请日：2023-08-01

Applicant: BioNTech SE

Inventor： Wolfgang Scholz ,  Ritsuko Sawada

IPC: C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  G01N33/574

CPC classification number: C07K16/3084 ,  A61K39/39558 ,  A61K45/06 ,  G01N33/57492 ,  A61K2039/505

Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against disialoganglioside-GD2. The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to GD2. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.

公开(公告)号：US11760809B2

公开(公告)日：2023-09-19

申请号：US17131713

申请日：2020-12-22

Applicant: BioNTech SE

Inventor： Wolfgang Scholz ,  Ritsuko Sawada

IPC: C07K16/00 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/3084 ,  A61K39/39558 ,  A61K45/06 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92 ,  G01N2405/10

Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against disialoganglioside-GD2. The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to GD2. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.