公开(公告)号：US11236103B2

公开(公告)日：2022-02-01

申请号：US16522481

申请日：2019-07-25

申请人： BioTheryX, Inc.

发明人： Kyle W. H. Chan ,  Aparajita Hoskote Chourasia ,  Paul E. Erdman ,  Leah Fung ,  David Aaron Hecht ,  Frank Mercurio ,  Robert Sullivan ,  Joseph P. Vacca

IPC分类号： C07D495/04 ,  A61P35/00 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14

摘要： The present application provides compounds that modulate CDK protein function. Methods of making the compounds, compositions containing the compounds, and uses of the compounds for treating or ameliorating of diseases, disorders, or conditions associated with CDK proteins, are also disclosed.

公开(公告)号：US20240190883A1

公开(公告)日：2024-06-13

申请号：US18542629

申请日：2023-12-16

申请人： BioTheryX, Inc.

发明人： Kyle W.H. Chan ,  Aparajita Hoskote Chourasia ,  Paul E. Erdman ,  Leah M. Fung ,  David Aaron Hecht ,  Imelda Lam ,  Patrick Papa ,  Angela Schoolmeesters ,  Eduardo Torres

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： Provided herein are KRAS protein degraders, for example, a compound of Formula (A), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a KRAS-mediated disorder, disease, or condition.

公开(公告)号：US20220298172A1

公开(公告)日：2022-09-22

申请号：US17804566

申请日：2022-05-30

申请人： BioTheryX, Inc.

发明人： Kyle W.H. Chan ,  Paul E. Erdman ,  Aparajita Hoskote Chourasia ,  Leah M. Fung ,  David Aaron Hecht ,  Imelda Lam ,  Frank Mercurio ,  Robert W. Sullivan ,  Eduardo Torres

IPC分类号： C07D495/04 ,  C07D401/04 ,  C07D401/14

摘要： The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.

公开(公告)号：US20200048277A1

公开(公告)日：2020-02-13

申请号：US16522481

申请日：2019-07-25

申请人： BioTheryX, Inc.

发明人： Kyle W.H. Chan ,  Aparajita Hoskote Chourasia ,  Paul E. Erdman ,  Leah Fung ,  David Aaron Hecht ,  Frank Mercurio ,  Robert Sullivan ,  Joseph P. Vacca

IPC分类号： C07D495/04 ,  A61P35/00 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14

摘要： The present application provides compounds that modulate CDK protein function. Methods of making the compounds, compositions containing the compounds, and uses of the compounds for treating or ameliorating of diseases, disorders, or conditions associated with CDK proteins, are also disclosed.

公开(公告)号：US20240025863A1

公开(公告)日：2024-01-25

申请号：US18245125

申请日：2021-09-16

申请人： BioTheryX, Inc.

发明人： Kyle W.H. Chan ,  Aparajita Hoskote Chourasia ,  Paul E. Erdman ,  Leah M. Fung ,  David Aaron Hecht ,  Imelda Lam ,  Patrick Papa ,  Angela Schoolmeesters ,  Eduardo Torres

IPC分类号： C07D239/94 ,  C07D409/12 ,  C07D487/04 ,  C07D471/04 ,  C07D403/14 ,  C07D401/14 ,  A61P35/00

CPC分类号： C07D239/94 ,  C07D409/12 ,  C07D487/04 ,  A61P35/00 ,  C07D403/14 ,  C07D401/14 ,  C07D471/04

摘要： Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an SOS1-mediated disorder, disease, or condition.

公开(公告)号：US20230002371A1

公开(公告)日：2023-01-05

申请号：US17753686

申请日：2020-09-14

申请人： BioTheryX, Inc.

发明人： Kyle W.H. Chan ,  Aparajita Hoskote Chourasia ,  Paul E. Erdman ,  Leah M. Fung ,  David Aaron Hecht ,  Imelda Lam ,  Frank Mercurio ,  Robert W. Sullivan ,  Eduardo Torres

IPC分类号： C07D471/04 ,  C07D401/14 ,  C07D495/04 ,  C07D417/14 ,  C07D471/14 ,  C07D405/14 ,  A61P35/00 ,  A61P11/00

摘要： Provided herein are RAS protein degraders, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RAS-mediated disorder, disease, or condition. RHct—L2—X—L1—R1  (1)

公开(公告)号：US11345712B2

公开(公告)日：2022-05-31

申请号：US16882750

申请日：2020-05-26

申请人： BioTheryX, Inc.

发明人： Kyle W. H. Chan ,  Paul E. Erdman ,  Leah Fung ,  David Aaron Hecht ,  Imelda Lam ,  Robert Sullivan ,  Eduardo Torres

IPC分类号： C07D495/04 ,  C07D401/04 ,  C07D401/14

摘要： The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.

公开(公告)号：US20220153751A1

公开(公告)日：2022-05-19

申请号：US17649405

申请日：2022-01-31

申请人： BioTheryX, Inc.

发明人： Kyle W.H. Chan ,  Aparajita Hoskote Chourasia ,  Paul E. Erdman ,  Leah M. Fung ,  David Aaron Hecht ,  Frank Mercurio ,  Robert W. Sullivan ,  Joseph P. Vacca

IPC分类号： C07D495/04 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14

摘要： The present application provides compounds that modulate CDK protein function. Methods of making the compounds, compositions containing the compounds, and uses of the compounds for treating or ameliorating of diseases, disorders, or conditions associated with CDK proteins, are also disclosed.

公开(公告)号：US20240124418A1

公开(公告)日：2024-04-18

申请号：US18256636

申请日：2021-12-13

申请人： BioTheryX, Inc.

发明人： Kyle W.H. Chan ,  Paul E. Erdman ,  Leah M. Fung ,  David Aaron Hecht ,  Frank Mercurio ,  Robert W. Sullivan ,  Aparajita Hoskote Chourasia ,  Patrick Papa

IPC分类号： C07D401/14 ,  C07D401/12 ,  C07D417/14 ,  C07D495/04

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D417/14 ,  C07D495/04

摘要： Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.

公开(公告)号：US20230071529A1

公开(公告)日：2023-03-09

申请号：US17757105

申请日：2020-12-14

申请人： BioTheryX, Inc.

发明人： Kyle W.H. Chan ,  Paul E. Erdman ,  Leah M. Fung ,  David Aaron Hecht ,  Frank Mercurio ,  Robert W. Sullivan

IPC分类号： C07D495/04 ,  C07D401/14 ,  C07D417/14 ,  C07F5/02 ,  C07D405/14

摘要： Provided herein are phosphodiesterase 4 (PDE4) inhibitors, e.g., a compound of Formula (I) or (II), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease, disorder, or condition associated with PDE4 malfunction.