公开(公告)号：US20190040077A1

公开(公告)日：2019-02-07

申请号：US16073705

申请日：2017-01-27

Applicant: BioVentures, LLC ,  The Regents of the University of Colorado

Inventor： Venumadhav Janganati ,  Peter Crooks ,  Jessica Ponder ,  Craig Jordan

IPC: C07D493/04 ,  A61P35/00 ,  C07C57/15

CPC classification number: C07D493/04 ,  A61K31/4192 ,  A61P35/00 ,  C07C57/15

Abstract: The present disclosure relates to triazole derivatives of melampomagnolide B, their synthesis, and their use as anti-cancer compounds.

公开(公告)号：US20170362254A1

公开(公告)日：2017-12-21

申请号：US15532413

申请日：2015-12-03

Applicant: BioVentures, LLC

Inventor： Venumadhav Janganati ,  Peter Crooks ,  Narsimha Reddy Penthala ,  Craig Jordan ,  Shobanbabu Bommagani ,  Jessica Ponder

IPC: C07D519/00 ,  C07F7/18

CPC classification number: C07D519/00 ,  C07F7/1804

Abstract: The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML). A compound comprising Formula (1) wherein: Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N.

公开(公告)号：US10428082B2

公开(公告)日：2019-10-01

申请号：US16073705

申请日：2017-01-27

Applicant: BioVentures, LLC ,  The Regents of the University of Colorado

Inventor： Venumadhav Janganati ,  Peter Crooks ,  Jessica Ponder ,  Craig Jordan

IPC: C07D493/04 ,  A61K31/4192 ,  A61P35/00 ,  C07C57/15

Abstract: The present disclosure relates to triazole derivatives of melampomagnolide B, their synthesis, and their use as anti-cancer compounds.

公开(公告)号：US10118935B2

公开(公告)日：2018-11-06

申请号：US15957524

申请日：2018-04-19

Applicant: BioVentures, LLC ,  The Regents of the University of Colorado, A Body Corporate

Inventor： Venumadhav Janganati ,  Peter Crooks ,  Narsimha Reddy Penthala ,  Craig Jordan ,  Shobanbabu Bommagani ,  Jessica Ponder

IPC: C07D519/00 ,  C07F7/18

Abstract: The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).

公开(公告)号：US20180237458A1

公开(公告)日：2018-08-23

申请号：US15957524

申请日：2018-04-19

Applicant: BioVentures, LLC ,  The Regents of the University of Colorado, A Body Corporate

Inventor： Venumadhav Janganati ,  Peter Crooks ,  Narsimha Reddy Penthala ,  Craig Jordan ,  Shobanbabu Bommagani ,  Jessica Ponder

IPC: C07D519/00 ,  C07F7/18

CPC classification number: C07D519/00 ,  C07F7/1804

Abstract: The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).

公开(公告)号：US09981990B2

公开(公告)日：2018-05-29

申请号：US15532413

申请日：2015-12-03

Applicant: BioVentures, LLC

Inventor： Venumadhav Janganati ,  Peter Crooks ,  Narsimha Reddy Penthala ,  Craig Jordan ,  Shobanbabu Bommagani ,  Jessica Ponder

IPC: C07D519/00 ,  C07F7/18

CPC classification number: C07D519/00 ,  C07F7/1804

Abstract: The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML). A compound comprising Formula (1) wherein: Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N.