公开(公告)号：US20240265532A1

公开(公告)日：2024-08-08

申请号：US18556411

申请日：2022-04-19

Applicant: Biocellvia

Inventor： Cindy SERDJEBI ,  Damien BARBES ,  Bastien LEPOIVRE ,  Karine BERTOTTI

IPC: G06T7/00 ,  G06T7/62 ,  G06V20/69

CPC classification number: G06T7/0012 ,  G06T7/62 ,  G06V20/695 ,  G06T2207/10024 ,  G06T2207/20036 ,  G06T2207/30024 ,  G06T2207/30096 ,  G06T2207/30101

Abstract: The invention relates to a method for producing a morphometric quantity of interest for a section of a human or animal organ on the basis of a first digital representation of a histological slide that has been subjected to a staining step that causes the pixels of said first digital representation to become different colours depending on whether said pixels describe emptiness, tissue or muscle cells. Said method especially consists in identifying pixels describing at least one polygon of interest in digital representations created from the first digital representation, in discerning, per polygon of interest, a lumen, an intima and a media of a vessel, and in producing at least one morphometric measurement of said vessel. Such a method comprises a step of producing a morphometric quantity of interest for the organ on the basis of said morphometric measurements of the identified vessels.

公开(公告)号：US20230117179A1

公开(公告)日：2023-04-20

申请号：US17907035

申请日：2020-03-24

Applicant: Biocellvia

Inventor： Yvon JULE ,  Florent TOMI ,  Damien BARBES ,  Karine BERTOTTI

IPC: G06T7/00 ,  C12N5/071 ,  G01N1/30

Abstract: The invention relates to a method for producing variables of interest relating to human or animal hepatic tissue from a digital representation of a histological section. Such a method is intended to be implemented by a unit for processing a medical imaging system to automatically and quickly provide diagnosis assistance, in particular for NASH, to healthcare personnel. The variables of interest respectively describe a level of steatosis of the hepatic tissue, a level of fibrosis in the portal, central and perisinusoidal areas of the hepatic lobule and a level of inflammation of the hepatic tissue. A method according to the invention further provides for producing a multiparametric indicator in the form of graphical representations arranged to be displayed by an output human-machine interface of the medical imaging system.