公开(公告)号：US20150353911A1

公开(公告)日：2015-12-10

申请号：US14406160

申请日：2013-06-07

Applicant: Biogen Idec MA Inc.

Inventor： Joe Salas ,  Elena Kistanova ,  Vu Phong Hong ,  Adam R. Mezo ,  Robert T. Peters

IPC: C12N9/64 ,  A61K38/48 ,  A61K47/48

CPC classification number: C12N9/6432 ,  A61K38/36 ,  A61K38/4846 ,  A61K47/62 ,  C12N9/6437 ,  C12Y304/21006 ,  C12Y304/21021

Abstract: The invention provides chimeric clotting factors comprising an activatable clotting factor and an enhancer moiety. The activatable clotting factor allows the chimeric clotting factor to be activated at the site of coagulation. The enhancer moiety can additionally improve procoagulation activities of the chimeric clotting factors. The chimeric clotting factors can further be improved by fusion to a half-life extender, which improves a pharmacokinetics property of the chimeric clotting factor. The invention also includes methods of making and methods of using these chimeric clotting factors.

Abstract translation: 本发明提供了包含可激活的凝血因子和增强子部分的嵌合凝血因子。 可激活的凝血因子允许嵌合凝血因子在凝血部位被活化。 增强子部分可另外改善嵌合凝血因子的促凝活性。 通过与半衰期延长剂的融合进一步改善嵌合凝血因子，这提高了嵌合凝血因子的药代动力学性质。 本发明还包括制备方法和使用这些嵌合凝血因子的方法。