公开(公告)号：US20150185235A1

公开(公告)日：2015-07-02

申请号：US14416214

申请日：2013-07-25

Applicant: Biogen Idec MA Inc.

Inventor： Jurg Sommer

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N33/92 ,  G01N2333/755 ,  G01N2333/9645 ,  G01N2800/224

Abstract: The present disclosure provides methods and compositions for diagnosing and treating subject having a bleeding disorder. The disclosed methods comprise contacting a sample, e.g., a blood or plasma sample obtained from the patient, with an activation mixture comprising an activated coagulation factor and a phospholipid mixture, wherein the activation mixture is dried onto a solid substrate. Also provided is a global hemostasis test based on the integration of clotting time (Ct) and pharmacokinetics data. The methods and compositions presented can be applied to point-of-care diagnostic systems.

Abstract translation: 本公开提供了用于诊断和治疗出血性疾病的受试者的方法和组合物。 所公开的方法包括使样品例如从患者获得的血液或血浆样品与包含活化凝血因子和磷脂混合物的活化混合物接触，其中将活化混合物干燥至固体基质上。 还提供了基于凝血时间（Ct）和药代动力学数据的整合的全球止血试验。 所提出的方法和组合可以应用于护理点诊断系统。