公开(公告)号：US20130295169A1

公开(公告)日：2013-11-07

申请号：US13827228

申请日：2013-03-14

Applicant: Biogen Idec MA Inc.

Inventor： David Goldman ,  Katherine Dawson ,  Ajay Nirula

IPC: A61K31/225 ,  A61K9/48 ,  A61K31/616 ,  A61K9/20

CPC classification number: A61K31/225 ,  A61K9/16 ,  A61K9/2054 ,  A61K9/2072 ,  A61K9/2833 ,  A61K9/2846 ,  A61K9/4808 ,  A61K31/60 ,  A61K31/616 ,  A61K45/06 ,  A61K2300/00

Abstract: Provided herein are compositions containing compounds, or pharmaceutically acceptable salts, that metabolize to monomethyl fumarate with certain pharmacokinetic parameters and methods for treating, prophylaxis, or amelioration of neurodegenerative diseases including multiple sclerosis using such compositions in a subject, wherein if the compositions contain dimethyl fumarate, the total amount of dimethyl fumarate in the compositions ranges from about 43% w/w to about 95% w/w.

公开(公告)号：US20130287732A1

公开(公告)日：2013-10-31

申请号：US13850240

申请日：2013-03-25

Applicant: Biogen Idec MA Inc.

Inventor： Susan GOELZ ,  Katherine Dawson ,  Ralf Linker ,  Ralf Gold

IPC: A61K31/225 ,  A61K38/21 ,  A61K38/02

CPC classification number: A61K31/225 ,  A61K9/2072 ,  A61K9/2846 ,  A61K9/4808 ,  A61K31/194 ,  A61K31/785 ,  A61K38/02 ,  A61K38/215 ,  A61K2300/00

Abstract: Methods of treating neurological disorders, e.g., those characterized by demyelination and/or axonal loss (e.g., MS), are provided. The methods comprise administration of a therapeutically effective amount of at least one compound of Formula I: wherein R1 and R2 are independently selected from OH, O−, and (C1-6)alkoxy, or a pharmaceutically acceptable salt thereof; and either glatiramer acetate or interferon-beta.

Abstract translation: 提供治疗神经系统疾病的方法，例如由脱髓鞘和/或轴突损失（例如MS）表征的那些。 所述方法包括施用治疗有效量的至少一种式I化合物：其中R 1和R 2独立地选自OH，O-和（C 1-6）烷氧基，或其药学上可接受的盐; 和醋酸格拉默或干扰素-β。

公开(公告)号：US20140163100A1

公开(公告)日：2014-06-12

申请号：US14119373

申请日：2012-05-25

Applicant: BIOGEN IDEC MA INC.

Inventor： Katherine Dawson ,  Gilmore O'Neill ,  Alfred Sandrock

IPC: A61K31/225

CPC classification number: A61K31/225 ,  A61K31/194

Abstract: Methods of treating multiple sclerosis in a subject, including: reducing the frequency of relapse, reducing the annualized relapse rate, reducing the risk of disability progression, reducing the number of new or newly enlarging T2 lesions, reducing the number of gadolinium lesions; and methods of preserving/increasing myelin content in a subject having multiple sclerosis; by daily administering a composition containing a fumarate, such as dimethyl fumarate or monomethyl fumarate, to the subject.

Abstract translation: 治疗多发性硬化症的方法包括：减少复发频率，降低年复发率，降低残疾进展的风险，减少新增或新扩大的T2病变数量，减少钆损伤数量; 以及在具有多发性硬化症的受试者中保存/增加髓磷脂含量的方法; 通过每天施用含有富马酸盐的富马酸盐的组合物，例如富马酸二甲酯或富马酸单甲酯。