公开(公告)号：US10035860B2

公开(公告)日：2018-07-31

申请号：US14772863

申请日：2014-03-14

Applicant: Biogen MA Inc.

Inventor： Shelia M. Violette ,  Paul H. Weinreb ,  Timothy David Jones ,  Francis Joseph Carr ,  Anja Sibylle Tessarz

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C07K16/28 ,  G01N33/53

CPC classification number: C07K16/2839 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/565 ,  G01N33/5308 ,  G01N2800/00

Abstract: Humanized antibodies and antibody fragments thereof that bind to αvβ6 are disclosed. Also disclosed are methods of using these antibodies and antibody fragments to diagnose, treat, and/or prevent αvβ6-mediated diseases such as acute tissue injury, fibrosis, and cancer.

公开(公告)号：US10035859B2

公开(公告)日：2018-07-31

申请号：US14772512

申请日：2014-03-14

Applicant: Biogen MA Inc.

Inventor： Shelia M. Violette ,  Paul H. Weinreb ,  Timothy David Jones ,  Francis Joseph Carr ,  Anja Sibylle Tessarz

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C07K16/28

CPC classification number: C07K16/2839 ,  C07K16/2842 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: Humanized antibodies and antibody fragments thereof that bind to αvβ6 are disclosed. Also disclosed are methods of using these antibodies and antibody fragments to treat or prevent αvβ6-mediated diseases such as fibrosis and cancer.

公开(公告)号：US20160031992A1

公开(公告)日：2016-02-04

申请号：US14772512

申请日：2014-03-14

Applicant: Biogen MA Inc.

Inventor： Shelia M. Violette ,  Paul H. Weinreb ,  Timothy David Jones ,  Francis Joseph Carr ,  Anja Sibylle Tessarz

IPC: C07K16/28

CPC classification number: C07K16/2839 ,  C07K16/2842 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: Humanized antibodies and antibody fragments thereof that bind to αvβ6 are disclosed. Also disclosed are methods of using these antibodies and antibody fragments to treat or prevent αvβ6-mediated diseases such as fibrosis and cancer.

Abstract translation: 公开了结合αv＆bgr6的人源化抗体及其抗体片段。 还公开了使用这些抗体和抗体片段来治疗或预防αvβb介导的疾病如纤维化和癌症的方法。

公开(公告)号：US20160017042A1

公开(公告)日：2016-01-21

申请号：US14772863

申请日：2014-03-14

Applicant: BIOGEN MA INC.

Inventor： Shelia M. Violette ,  Paul H. Weinreb ,  Timothy David Jones ,  Francis Joseph Carr ,  Anja Sibylle Tessarz

IPC: C07K16/28 ,  G01N33/53

CPC classification number: C07K16/2839 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/565 ,  G01N33/5308 ,  G01N2800/00

Abstract: Humanized antibodies and antibody fragments thereof that bind to αvβ6 are disclosed. Also disclosed are methods of using these antibodies and antibody fragments to diagnose, treat, and/or prevent αvβ6-mediated diseases such as acute tissue injury, fibrosis, and cancer.

Abstract translation: 公开了结合αv＆bgr6的人源化抗体及其抗体片段。 还公开了使用这些抗体和抗体片段诊断，治疗和/或预防αvβb介导的疾病如急性组织损伤，纤维化和癌症的方法。