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公开(公告)号：US09029357B2
公开(公告)日：2015-05-12
申请号：US14317024
申请日：2014-06-27
申请人： Bioprojet
发明人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Denis Danvy , Stéphane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
IPC分类号： A61K31/506 , A61K31/428 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , C07D417/14 , C07D401/12 , C07D405/14 , C07D417/12 , A61K45/06 , C07D401/14 , C07D401/04 , C07D417/04
CPC分类号： C07D417/14 , A61K31/428 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/04 , C07D417/12
摘要： The present patent application concerns new ligands of the H4-receptor, their process of preparation and their therapeutic use.
摘要翻译： 本专利申请涉及H4受体的新配体，其制备方法及其治疗用途。
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公开(公告)号：US12059416B2
公开(公告)日：2024-08-13
申请号：US17456617
申请日：2021-11-26
申请人： BIOPROJET
IPC分类号： A61K31/4545 , A61K31/381 , A61K31/4453 , A61P25/26
CPC分类号： A61K31/4545 , A61K31/381 , A61K31/4453 , A61P25/26
摘要： Disclosed are combinations of a H3 antagonist and an antidepressant, which exhibit a synergistic wake promoting activity.
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公开(公告)号：US11229632B2
公开(公告)日：2022-01-25
申请号：US16431063
申请日：2019-06-04
申请人： BIOPROJET
IPC分类号： A61K31/4545 , A61K31/381 , A61K31/4453 , A61P25/26
摘要： The present invention relates to combinations of a H3 antagonist and an antidepressant, which exhibit a synergistic wake promoting activity.
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公开(公告)号：US11306069B2
公开(公告)日：2022-04-19
申请号：US16192162
申请日：2018-11-15
申请人： BIOPROJET
发明人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Stéphane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
IPC分类号： C07D401/12 , A61P37/08 , A61P29/00 , A61K45/06 , A61K31/454
摘要： Novel benzimidazole enantiomeric derivatives, their process of preparation and their therapeutical uses as dual H1 and H4 receptor ligands are disclosed.
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公开(公告)号：US10952987B2
公开(公告)日：2021-03-23
申请号：US16223750
申请日：2018-12-18
申请人： BIOPROJET
发明人： Jean-Charles Schwartz , Xavier Ligneau , Laurent François Gérard Landais , David Perrin , Jeanne-Marie Lecomte
IPC分类号： A61K31/335 , A61K45/06 , A61K31/137 , A61K9/00
摘要： The present invention concerns a novel combination of adrenalin with an antidepressant and its use as a pharmaceutical composition for the treatment of shocks. A method is also provided for treating a subject in need thereof by administering the combination of adrenaline with an antidepressant. The pharmaceutical composition is to be administered by injection.
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6.发明授权(Aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications 有权（Aza）二苯甲醚衍生物，其制备方法及其用作治疗用途的H4-受体配体公开(公告)号：US09242959B2
公开(公告)日：2016-01-26
申请号：US13910651
申请日：2013-06-05
申请人： BIOPROJET
发明人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Stéphane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
IPC分类号： A61K31/4545 , A61K31/445 , A61K45/06 , C07D401/12 , C07D211/22 , C07D211/46
CPC分类号： C07D401/12 , A61K31/445 , A61K31/4545 , A61K45/06 , C07D211/22 , C07D211/46
摘要： The present invention concerns novel (aza)benzhydryl ether derivatives which exhibit H4-receptor binding activity. The present invention also concerns their process of preparation and their therapeutical uses.
摘要翻译： 本发明涉及具有H 4 - 受体结合活性的新型（aza）二苯甲醚衍生物。 本发明还涉及它们的制备方法及其治疗用途。
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