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公开(公告)号：US07235574B2
公开(公告)日：2007-06-26
申请号：US11073227
申请日：2005-03-04
IPC分类号： A61K31/422 , C07D413/02
CPC分类号： C07D413/12 , C07D413/10
摘要： The present invention provides the compounds of formula I-A their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式IA化合物其药学上可接受的盐或酯，对映异构体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述 控制或预防疾病如癌症的化合物。
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公开(公告)号：US20050197370A1
公开(公告)日：2005-09-08
申请号：US11073227
申请日：2005-03-04
IPC分类号： C07D413/10 , C07D413/12 , A61K31/422 , C07D413/02
CPC分类号： C07D413/12 , C07D413/10
摘要： The present invention provides the compounds of formula I-A their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式IA化合物其药学上可接受的盐或酯，对映异构体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述 控制或预防疾病如癌症的化合物。
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公开(公告)号：US07179812B2
公开(公告)日：2007-02-20
申请号：US11096286
申请日：2005-03-31
IPC分类号： C07D413/14 , A61K31/497 , A61K31/501 , A61K31/506
CPC分类号： C07D413/14
摘要： The present invention provides compounds of formula (I): their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式（I）化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法以及上述用途 用于控制或预防癌症等疾病的化合物。
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公开(公告)号：US07405231B2
公开(公告)日：2008-07-29
申请号：US11073065
申请日：2005-03-04
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
IPC分类号： A61K31/41 , C07D249/04
CPC分类号： C07D417/12 , C07D413/12
摘要： The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式I化合物的药学上可接受的盐或酯，对映异构体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述 控制或预防疾病如癌症的化合物。
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公开(公告)号：US07259262B2
公开(公告)日：2007-08-21
申请号：US10965996
申请日：2004-10-15
IPC分类号： C07D263/32 , C07D277/22 , A01N43/76 , A01N43/78
CPC分类号： C07D417/14 , C07D413/14
摘要： There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 提供式（I）化合物的药学上可接受的盐，其对映体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。
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公开(公告)号：US20050038091A1
公开(公告)日：2005-02-17
申请号：US10910765
申请日：2004-08-03
IPC分类号： C07D413/12 , C07D413/02 , A61K31/422
CPC分类号： C07D413/12
摘要： The present invention relates to novel oxazoles of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明涉及式（I）的新颖恶唑，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述用途 控制或预防疾病如癌症的化合物。
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公开(公告)号：US07205326B2
公开(公告)日：2007-04-17
申请号：US10833721
申请日：2004-04-28
IPC分类号： A61K31/422 , C07D263/30 , C07D413/02
CPC分类号： C07D413/12 , C07D413/14
摘要： Compounds of formula (I) are useful in the therapy and/or prevention of illnesses with known over-expression of receptor tyrosine kinases of the HER-family like HER-2 and EGFR (HER-1). Accordingly, these compounds are useful for the treatment of diseases such as cancer in humans or animals.
摘要翻译： 式（I）化合物
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8.发明申请Novel arylazole derivatives, their manufacture and use as pharmaceutical agents 失效新型芳基唑衍生物，其制造和用作药剂公开(公告)号：US20050124670A1
公开(公告)日：2005-06-09
申请号：US10965996
申请日：2004-10-15
IPC分类号： A61K31/4155 , A61K31/4192 , A61K31/422 , A61K31/426 , C07D413/14 , C07D417/14 , C07D277/38 , A61K31/427 , C07D413/02 , C07D417/02
CPC分类号： C07D417/14 , C07D413/14
摘要： There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 提供式（I）化合物的药学上可接受的盐，其对映体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。
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公开(公告)号：US07247649B2
公开(公告)日：2007-07-24
申请号：US10910765
申请日：2004-08-03
IPC分类号： A61K31/422 , C07D263/30 , C07D413/12
CPC分类号： C07D413/12
摘要： The present invention relates to novel oxazoles of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明涉及式（I）的新颖恶唑，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述用途 控制或预防疾病如癌症的化合物。
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公开(公告)号：US20050203064A1
公开(公告)日：2005-09-15
申请号：US11073065
申请日：2005-03-04
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
IPC分类号： C07D413/12 , C07D417/12 , A61K31/675 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D263/30 , C07D277/22
CPC分类号： C07D417/12 , C07D413/12
摘要： The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式I化合物的药学上可接受的盐或酯，对映异构体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述 控制或预防疾病如癌症的化合物。
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