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公开(公告)号：US07205325B2
公开(公告)日：2007-04-17
申请号：US10808935
申请日：2004-03-25
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Bernhard Goller , Matthias Rueth , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Bernhard Goller , Matthias Rueth , Edgar Voss
IPC分类号： A61K31/4192 , C07D249/04
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention 1 includes compounds of formula (I), and their pharmaceutically acceptable salts. These compounds are useful in the control or prevention of cancer.
摘要翻译： 本发明1包括式（I）的化合物，
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公开(公告)号：US07405231B2
公开(公告)日：2008-07-29
申请号：US11073065
申请日：2005-03-04
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
IPC分类号： A61K31/41 , C07D249/04
CPC分类号： C07D417/12 , C07D413/12
摘要： The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式I化合物的药学上可接受的盐或酯，对映异构体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述 控制或预防疾病如癌症的化合物。
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公开(公告)号：US20050203064A1
公开(公告)日：2005-09-15
申请号：US11073065
申请日：2005-03-04
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
IPC分类号： C07D413/12 , C07D417/12 , A61K31/675 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D263/30 , C07D277/22
CPC分类号： C07D417/12 , C07D413/12
摘要： The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式I化合物的药学上可接受的盐或酯，对映异构体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述 控制或预防疾病如癌症的化合物。
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公开(公告)号：US20050267179A1
公开(公告)日：2005-12-01
申请号：US11132082
申请日：2005-05-18
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
IPC分类号： A61K31/422 , A61P35/00 , C07D413/02 , C07D413/12
CPC分类号： C07D413/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法，以及上述化合物在 控制或预防癌症等疾病。
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公开(公告)号：US07005526B2
公开(公告)日：2006-02-28
申请号：US11132082
申请日：2005-05-18
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
IPC分类号： C07D263/32 , C07D249/04 , A61K31/422 , A61K31/4192
CPC分类号： C07D413/12
摘要： Objects of the present invention are the compounds of formula (I) formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）式（I）的化合物，化学式id =“CHEM-US-00001”num =“000
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公开(公告)号：US20050209290A1
公开(公告)日：2005-09-22
申请号：US11083176
申请日：2005-03-17
IPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , A61K31/427 , A61K31/422 , C07D413/02 , C07D417/02
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14
摘要： The present invention provides the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式（I）化合物的药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的组合物及其制备方法，以及上述用途， 提及的化合物在控制或预防诸如癌症的疾病中。
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公开(公告)号：US07163953B2
公开(公告)日：2007-01-16
申请号：US11131576
申请日：2005-05-18
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Christian Geletneky , Guy Georges , Irene Kolm , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Christian Geletneky , Guy Georges , Irene Kolm , Edgar Voss
IPC分类号： A61K31/422 , C07D263/30 , C07D413/12
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法，以及使用 上述化合物控制或预防诸如癌症等疾病。
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公开(公告)号：US07432291B2
公开(公告)日：2008-10-07
申请号：US11083176
申请日：2005-03-17
IPC分类号： A61K31/41 , C07D249/04
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14
摘要： The present invention provides the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式（I）化合物的药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的组合物及其制备方法，以及上述用途， 提及的化合物在控制或预防诸如癌症的疾病中。
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公开(公告)号：US20050267178A1
公开(公告)日：2005-12-01
申请号：US11131576
申请日：2005-05-18
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Christian Geletneky , Guy Georges , Irene Kolm , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Christian Geletneky , Guy Georges , Irene Kolm , Edgar Voss
IPC分类号： C07D413/12 , C07D521/00 , A61K31/422 , C07D413/02
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法，以及使用 上述化合物控制或预防诸如癌症等疾病。
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公开(公告)号：US20070032530A1
公开(公告)日：2007-02-08
申请号：US11497145
申请日：2006-08-01
申请人： Birgit Bossenmaier , Thomas Friess , Rolf Juchem , Lothar Kling , Irene Kolm , Hans-Willi Krell , Thomas von Hirschheydt , Edgar Voss
发明人： Birgit Bossenmaier , Thomas Friess , Rolf Juchem , Lothar Kling , Irene Kolm , Hans-Willi Krell , Thomas von Hirschheydt , Edgar Voss
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/12
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing such compounds and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明涉及式I化合物：其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有这些化合物的药物组合物及其制备方法以及这些化合物在 控制或预防癌症等疾病。
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