公开(公告)号：US10800774B2

公开(公告)日：2020-10-13

申请号：US16104561

申请日：2018-08-17

申请人： Board of Regents, The University of Texas System ,  ChemPartner Corporation

发明人： Maria Emilia Di Francesco ,  Philip Jones ,  Christopher Lawrence Carroll ,  Jason Bryant Cross ,  Zhijun Kang ,  Michael Garrett Johnson ,  Sarah Lively

IPC分类号： C07D471/04 ,  C07D413/14 ,  A61P35/00

摘要： The present invention relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

公开(公告)号：US10745420B2

公开(公告)日：2020-08-18

申请号：US16539693

申请日：2019-08-13

申请人： Board of Regents, The University of Texas System ,  ChemPartner Corporation

发明人： Maria Emilia Di Francesco ,  Philip Jones ,  Christopher Lawrence Carroll ,  Jason Bryant Cross ,  Michael Garrett Johnson ,  Sarah Lively

IPC分类号： C07D519/00 ,  A61P35/00

摘要： The present invention relates to tetrahydropyrido[4,3-d]pyrimidine based compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

公开(公告)号：US10800769B2

公开(公告)日：2020-10-13

申请号：US16507851

申请日：2019-07-10

申请人： Board of Regents, The University of Texas System ,  ChemPartner Corporation

发明人： Maria Emilia Di Francesco ,  Philip Jones ,  Christopher Lawrence Carroll ,  Jason Bryant Cross ,  Suyambu Kesava Vijayan Ramaswamy ,  Michael Garrett Johnson ,  Sarah Lively ,  David Lapointe

IPC分类号： C07D413/14 ,  C07D413/04 ,  C07D411/14 ,  A61K45/06 ,  C07D471/04 ,  A61P35/00 ,  C07D417/14

摘要： The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

公开(公告)号：US11434233B2

公开(公告)日：2022-09-06

申请号：US17009428

申请日：2020-09-01

申请人： Board of Regents, The University of Texas System ,  ChemPartner Corporation

发明人： Maria Emilia Di Francesco ,  Philip Jones ,  Christopher Lawrence Carroll ,  Jason Bryant Cross ,  Suyambu Kesava Vijayan Ramaswamy ,  Michael Garrett Johnson ,  Sarah Lively ,  David Lapointe

IPC分类号： C07D413/14 ,  C07D413/04 ,  C07D411/14 ,  C07D471/04 ,  C07D417/14 ,  A61K45/06 ,  A61P35/00

摘要： The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

公开(公告)号：US10894052B2

公开(公告)日：2021-01-19

申请号：US16356450

申请日：2019-03-18

申请人： Board of Regents, The University of Texas System ,  ChemPartner Corporation

发明人： Maria Emilia Di Francesco ,  Philip Jones ,  Christopher Lawrence Carroll ,  Suyambu Kesava Vijayan Ramaswamy ,  Zhijun Kang ,  Michael Garrett Johnson ,  Sarah Lively ,  David Lapointe

IPC分类号： C07D413/14 ,  C07D471/04 ,  A61K31/5377 ,  A61P35/00

摘要： The present disclosure relates to heterocyclic compounds and methods which inhibit ATR kinase to treat or prevent cancer.

公开(公告)号：US10421765B2

公开(公告)日：2019-09-24

申请号：US15990283

申请日：2018-05-25

申请人： Board of Regents, The University of Texas System ,  ChemPartner Corporation

发明人： Maria Emilia Di Francesco ,  Philip Jones ,  Christopher Lawrence Carroll ,  Jason Bryant Cross ,  Michael Garrett Johnson ,  Sarah Lively

IPC分类号： C07D519/00 ,  A61P35/00

摘要： The present invention relates to tetrahydropyrido[4,3-d]pyrimidine based compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

公开(公告)号：US10392376B2

公开(公告)日：2019-08-27

申请号：US16035310

申请日：2018-07-13

申请人： Board of Regents, The University of Texas System

发明人： Maria Emilia Di Francesco ,  Philip Jones ,  Christopher Lawrence Carroll ,  Jason Bryant Cross ,  Suyambu Kesava Vijayan Ramaswamy ,  Michael Garrett Johnson ,  Sarah Lively ,  David Lapointe

IPC分类号： C07D413/14 ,  C07D413/04 ,  C07D411/14 ,  C07D417/14 ,  C07D471/04 ,  A61K45/06 ,  A61P35/00

摘要： The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.