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公开(公告)号：US10800774B2
公开(公告)日：2020-10-13
申请号：US16104561
申请日：2018-08-17
发明人： Maria Emilia Di Francesco , Philip Jones , Christopher Lawrence Carroll , Jason Bryant Cross , Zhijun Kang , Michael Garrett Johnson , Sarah Lively
IPC分类号： C07D471/04 , C07D413/14 , A61P35/00
摘要： The present invention relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
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公开(公告)号：US10766892B2
公开(公告)日：2020-09-08
申请号：US16412050
申请日：2019-05-14
发明人： Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Kang Le , Christopher Lawrence Carroll , Wylie S. Palmer , Richard Lewis , Timothy McAfoos , Barbara Czako , Gang Liu , Jay Theroff , Zachary Herrera , Anne Yau
IPC分类号： C07D417/14 , A61K31/4439 , A61K45/06 , C07D417/06 , A61K31/433 , C07D403/06 , A61K31/501 , C07D401/14 , A61K31/454 , A61K31/4192 , C07D405/14 , C07D403/14 , A61K31/444 , C07D493/08 , A61K31/497
摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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![Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase](/abs-image/US/2020/08/18/US10745420B2/abs.jpg.150x150.jpg)
公开(公告)号：US10745420B2
公开(公告)日：2020-08-18
申请号：US16539693
申请日：2019-08-13
发明人： Maria Emilia Di Francesco , Philip Jones , Christopher Lawrence Carroll , Jason Bryant Cross , Michael Garrett Johnson , Sarah Lively
IPC分类号： C07D519/00 , A61P35/00
摘要： The present invention relates to tetrahydropyrido[4,3-d]pyrimidine based compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
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公开(公告)号：US10800769B2
公开(公告)日：2020-10-13
申请号：US16507851
申请日：2019-07-10
发明人： Maria Emilia Di Francesco , Philip Jones , Christopher Lawrence Carroll , Jason Bryant Cross , Suyambu Kesava Vijayan Ramaswamy , Michael Garrett Johnson , Sarah Lively , David Lapointe
IPC分类号： C07D413/14 , C07D413/04 , C07D411/14 , A61K45/06 , C07D471/04 , A61P35/00 , C07D417/14
摘要： The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
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公开(公告)号：US09809588B2
公开(公告)日：2017-11-07
申请号：US14791186
申请日：2015-07-02
发明人： Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Kang Le , Christopher Lawrence Carroll , Wylie S. Palmer , Richard Lewis , Timothy McAfoos , Barbara Czako , Gang Liu , Jay Theroff , Zachary Herrera , Anne Yau
IPC分类号： C07D417/14 , C07D417/06 , C07D403/06 , C07D405/14 , C07D403/14 , C07D493/08 , C07D401/14 , A61K31/433 , A61K31/501 , A61K31/497 , A61K45/06 , A61K31/4439 , A61K31/454 , A61K31/4192 , A61K31/444
CPC分类号： C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号：US20160002204A1
公开(公告)日：2016-01-07
申请号：US14791284
申请日：2015-07-03
发明人： Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Christopher Lawrence Carroll , Timothy McAfoos , Wylie Palmer , Zachary Herrera
IPC分类号： C07D401/06 , A61K31/444 , A61K45/06 , A61K31/4439 , C07D401/14 , A61K31/501 , C07D403/06 , A61K31/513 , C07D417/06 , C07D487/04 , A61K31/519 , A61K31/4545 , C07D405/14 , C07D403/14 , C07D409/14 , A61K31/5377 , A61K31/541 , A61N5/10 , A61N7/00 , C07D417/14
CPC分类号： C07D401/06 , A61K31/00 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/501 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04
摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号：US11370786B2
公开(公告)日：2022-06-28
申请号：US16925974
申请日：2020-07-10
发明人： Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Kang Le , Christopher Lawrence Carroll , Wylie S. Palmer , Richard Lewis , Timothy McAfoos , Barbara Czako , Gang Liu , Jay Theroff , Zachary Herrera , Anne Yau
IPC分类号： C07D417/14 , A61K31/4439 , A61K45/06 , C07D417/06 , A61K31/433 , C07D403/06 , A61K31/501 , C07D401/14 , A61K31/454 , A61K31/4192 , C07D405/14 , C07D403/14 , A61K31/444 , C07D493/08 , A61K31/497
摘要： Disclosed herein are compounds of structural Formula VIIa or VIIb: or a pharmaceutically acceptable salt thereof, and compositions thereof useful in the treatment of GLS1 mediated diseases, such as cancer. Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号：US10392376B2
公开(公告)日：2019-08-27
申请号：US16035310
申请日：2018-07-13
发明人： Maria Emilia Di Francesco , Philip Jones , Christopher Lawrence Carroll , Jason Bryant Cross , Suyambu Kesava Vijayan Ramaswamy , Michael Garrett Johnson , Sarah Lively , David Lapointe
IPC分类号： C07D413/14 , C07D413/04 , C07D411/14 , C07D417/14 , C07D471/04 , A61K45/06 , A61P35/00
摘要： The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
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公开(公告)号：US10344025B2
公开(公告)日：2019-07-09
申请号：US15624168
申请日：2017-06-15
发明人： Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Kang Le , Christopher Lawrence Carroll , Wylie S. Palmer , Richard Lewis , Timothy McAfoos , Barbara Czako , Gang Liu , Jay Theroff , Zachary Herrera , Anne Yau
IPC分类号： C07D417/14 , A61K31/4439 , A61K45/06 , C07D417/06 , A61K31/433 , C07D401/14 , A61K31/454 , A61K31/4192 , C07D405/14 , C07D403/14 , A61K31/444 , C07D493/08 , A61K31/497 , C07D403/06 , A61K31/501
摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号：US20160009704A1
公开(公告)日：2016-01-14
申请号：US14791186
申请日：2015-07-02
发明人： Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Kang Le , Christopher Lawrence Carroll , Wylie S. Palmer , Richard Lewis , Timothy McAfoos , Barbara Czako , Gang Liu , Jay Theroff , Zachary Herrera , Anne Yau
IPC分类号： C07D417/14 , A61K45/06 , C07D417/06 , A61K31/433 , C07D403/06 , A61K31/501 , C07D401/14 , A61K31/454 , A61K31/4192 , C07D405/14 , C07D403/14 , A61K31/444 , C07D493/08 , A61K31/497 , A61K31/4439
CPC分类号： C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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