公开(公告)号：US10591468B2

公开(公告)日：2020-03-17

申请号：US15900680

申请日：2018-02-20

Applicant: Board of Regents of the University of Nebraska

Inventor： Geoffrey M. Thiele ,  Daniel R. Anderson ,  Michael J. Duryee

IPC: A61P9/10 ,  G01N33/68 ,  G01N33/564 ,  G01N33/53 ,  A61K49/00 ,  C07K16/06 ,  C07K16/18 ,  C07K16/42

Abstract: In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde-acetaldheyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction.

公开(公告)号：US20200249224A1

公开(公告)日：2020-08-06

申请号：US16782015

申请日：2020-02-04

Applicant: Board of Regents of the University of Nebraska

Inventor： Geoffrey M. Thiele ,  Daniel R. Anderson ,  Michael J. Duryee

IPC: G01N33/53 ,  G01N33/68 ,  A61P9/10 ,  A61K49/00 ,  G01N33/564

Abstract: In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde acetaldehyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction.

公开(公告)号：US11542341B2

公开(公告)日：2023-01-03

申请号：US16782015

申请日：2020-02-04

Applicant: Board of Regents of the University of Nebraska

Inventor： Geoffrey M. Thiele ,  Daniel R. Anderson ,  Michael J. Duryee

IPC: C07K16/42 ,  C07K14/47 ,  G01N33/564 ,  G01N33/68 ,  A61P9/10 ,  C07K16/06 ,  C07K16/18 ,  A61K49/00 ,  G01N33/53

Abstract: In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde acetaldehyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction.