公开(公告)号：US10695338B2

公开(公告)日：2020-06-30

申请号：US15571917

申请日：2016-05-06

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： James Allen Cardelli ,  Magdalena Liliana Circu ,  Samantha Sarah Dykes ,  Hazem Edmond El-Osta

IPC分类号： A61K31/46 ,  A61P19/02 ,  A61P25/00 ,  A61P35/00 ,  A61K45/06 ,  A61K31/4535

摘要： Methods and compositions for treating a lysosomal movement associated disease in an animal, in which the position of lysosomes can influence disease progression, comprising administering an effective amount of a first lysosome migration inhibitor or a pharmaceutically acceptable salt, solvate, clathrate, stereoisomer, enantiomer or prodrug thereof.

公开(公告)号：US10959968B2

公开(公告)日：2021-03-30

申请号：US16070052

申请日：2017-01-13

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College ,  Board of Supervisors for the University of Louisiana System

发明人： James Allen Cardelli ,  Ana-Maria Dragoi ,  Khalid El-Sayed ,  Mohamed M. Mohyeldin

IPC分类号： A61K31/192 ,  A61P35/00 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/44

摘要： A method of treating cancer or a precancer condition in a mammal comprising administering a therapeutically effective amount of a homovanillyl sinapate analog or pharmacologically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, or a combination thereof.

公开(公告)号：US11744827B2

公开(公告)日：2023-09-05

申请号：US16916061

申请日：2020-06-29

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： James Allen Cardelli ,  Magdalena Liliana Circu ,  Samantha Sarah Dykes ,  Hazem Edmond El-Osta

IPC分类号： A61K31/46 ,  A61K45/06 ,  A61P19/02 ,  A61P25/00 ,  A61P35/00 ,  A61K31/4535

CPC分类号： A61K31/46 ,  A61K31/4535 ,  A61K45/06 ,  A61P19/02 ,  A61P25/00 ,  A61P35/00

摘要： Methods and compositions for treating a lysosomal movement associated disease in an animal, in which the position of lysosomes can influence disease progression, comprising administering an effective amount of a first lysosome migration inhibitor or a pharmaceutically acceptable salt, solvate, clathrate, stereoisomer, enantiomer or prodrug thereof.

公开(公告)号：US11096952B2

公开(公告)日：2021-08-24

申请号：US16074566

申请日：2017-02-02

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： James Allen Cardelli ,  Charles Albert Stephens ,  Alana Lea Gray ,  David Thomas Coleman

IPC分类号： A61K31/7048 ,  A61K31/4709 ,  A61K45/06 ,  A61P7/04 ,  A61P35/00 ,  A61K31/704 ,  A61K31/045 ,  A61K31/4412 ,  A61K31/496

摘要： A method of treating an activated fibroblast associated disease or pre-disease condition in a mammal comprising, administering a pharmaceutical composition including a therapeutically effective amount of a first therapeutic, wherein the first therapeutic is one of an intracellular Ca2+ elevator, a YAP/TAZ inhibitor, both a intracellular Ca2+ elevator and a YAP/TAZ inhibitor, or pharmacologically acceptable salts, solvates, esters, amides, clathrates, stereoisomers, enantiomers, prodrugs or analogs thereof, or a combination thereof.