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公开(公告)号：US20200347136A1
公开(公告)日：2020-11-05
申请号：US16865295
申请日：2020-05-01
发明人： Seetharama JOIS
IPC分类号： C07K16/28
摘要： Chemicals and methods of treating autoimmune/inflammatory diseases, comprising administering to a patient the functional groups of a CD58-targeted peptide grafted onto a cyclic scaffold. An additional embodiment includes wherein one or more of the functional groups of the peptide bind to CD58. An additional embodiment includes wherein the scaffold is chosen from the group of sunflower trypsin inhibitor (SFTI) and theta-defensins.
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公开(公告)号：US10959968B2
公开(公告)日：2021-03-30
申请号：US16070052
申请日：2017-01-13
申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College , Board of Supervisors for the University of Louisiana System
IPC分类号： A61K31/192 , A61P35/00 , A61K31/4196 , A61K31/4245 , A61K31/44
摘要： A method of treating cancer or a precancer condition in a mammal comprising administering a therapeutically effective amount of a homovanillyl sinapate analog or pharmacologically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, or a combination thereof.
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3.发明申请公开(公告)号：US20210121518A1
公开(公告)日：2021-04-29
申请号：US16970198
申请日：2019-02-15
发明人： Seetharama D. JOIS
摘要： A method of treating cancer in a mammalian patient comprising administering a pharmaceutical composition to the patient including a pharmacologically effective amount of a first therapeutic, wherein the first therapeutic comprises one or more HER2-targeted peptide functional groups grafted onto a cyclic scaffold, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analogs thereof. In a further embodiment, the one or more HER2-targeted peptide functional groups grafted onto a cyclic scaffold contains at least one 3-amino 3(1-napthyl) propionic acid bound to the scaffold.
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公开(公告)号：US10945983B2
公开(公告)日：2021-03-16
申请号：US16079122
申请日：2017-07-21
IPC分类号： A61K31/222 , C07C67/56 , C07C67/58 , A61P17/02 , A61P17/00 , A61P35/00 , A61K9/107 , C07C69/738
摘要： A method for extracting S (-)-Oleocanthal from olive oil comprising mixing a first volume of water with a second volume of olive oil to form an olive oil/water mixture; letting the olive oil/water mixture stand; removing an aqueous fraction from the olive oil/water mixture leaving a reduced S (-)-Oleocanthal containing olive oil; and filtering the aqueous fraction to create aqueous S (-)-Oleocanthal.
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公开(公告)号：US20190328690A1
公开(公告)日：2019-10-31
申请号：US16070052
申请日：2017-01-13
申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College , Board of Supervisors for the University of Louisiana System
IPC分类号： A61K31/192 , A61K31/4245 , A61K31/4196 , A61P35/00 , A61K31/44
摘要： A method of treating cancer or a precancer condition in a mammal comprising administering a therapeutically effective amount of a homovanillyl sinapate analog or pharmacologically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, or a combination thereof.
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公开(公告)号：US20190192469A1
公开(公告)日：2019-06-27
申请号：US16079122
申请日：2017-07-21
IPC分类号： A61K31/222 , A61P35/00
CPC分类号： A61K31/222 , A61K9/1075 , A61P17/00 , A61P17/02 , A61P35/00 , C07C67/56 , C07C67/58 , C07C69/738
摘要： A method for extracting S (-)-Oleocanthal from olive oil comprising mixing a first volume of water with a second volume of olive oil to form an olive oil/water mixture; letting the olive oil/water mixture stand; removing an aqueous fraction from the olive oil/water mixture leaving a reduced S (-)-Oleocanthal containing olive oil; and filtering the aqueous fraction to create aqueous S (-)-Oleocanthal.
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