公开(公告)号：US20190328690A1

公开(公告)日：2019-10-31

申请号：US16070052

申请日：2017-01-13

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College ,  Board of Supervisors for the University of Louisiana System

发明人： James Allen CARDELLI ,  Ana-Maria DRAGOI ,  Khalid EL-SAYED ,  Mohamed M. MOHYELDIN

IPC分类号： A61K31/192 ,  A61K31/4245 ,  A61K31/4196 ,  A61P35/00 ,  A61K31/44

摘要： A method of treating cancer or a precancer condition in a mammal comprising administering a therapeutically effective amount of a homovanillyl sinapate analog or pharmacologically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, or a combination thereof.

公开(公告)号：US20170258929A1

公开(公告)日：2017-09-14

申请号：US15430123

申请日：2017-02-10

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： James CARDELLI ,  Ana-Maria DRAGOI

IPC分类号： A61K38/09 ,  A61K31/12 ,  A61K31/7068

摘要： The invention provides combinations and formulations including a luteinizing hormone-releasing hormone (LHRH) or a LHRH analog; and curcumin or a curcumin analog. LHRH or LHRH analog can be fused or conjugated to a curcumin or curcumin analog. Invention combinations and formulations can also include an anti-cell proliferative drug. Invention combinations and formulations can be used for inhibiting proliferation of a cell; treating a hyperproliferative disorder; and treating a neoplasia, tumor, cancer or malignancy.