公开(公告)号：US20220112183A1

公开(公告)日：2022-04-14

申请号：US17498027

申请日：2021-10-11

申请人： Boehringer Ingelheim International GmbH

发明人： Julia Regina GRIMM ,  Katrin BAER ,  Albert Josef BARTA ,  Gisela BODENBACH ,  Joe Ju GAO ,  Fredrik Lars NORDSTROM ,  Michael WIESE ,  Bing-Shiou YANG ,  Manabu NAKATANI ,  Masashi ADACHI ,  Kenji EGUSA ,  Roman Christian MESSERSCHMID ,  Daniela Maria SCHROEDER

IPC分类号： C07D413/04 ,  A61K9/20 ,  A61K31/422

摘要： The invention describes a process for reworking of a crystallization product comprising drying and homogenization. The crystallization product is crystalline [5-(methylsulfonyl)-2-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}phenyl]{(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hex-3-yl}methanone. The product is dried in a tray dryer or in a pan dryer and subsequently homogenized.