公开(公告)号：US20220332710A1

公开(公告)日：2022-10-20

申请号：US17849935

申请日：2022-06-27

申请人： Boehringer Ingelheim International GmbH

发明人： Joe Ju GAO ,  Peter SIEGER ,  Bing-Shiou YANG

IPC分类号： C07D413/04

摘要： Disclosed are solid forms of an inhibitor of glycine transporter-1 (GlyT1). The invention also relates to methods of making these solid forms, pharmaceutical compositions comprising these solid forms, and their use for medical conditions responsive to treatment with an inhibitor of glycine transporter-1.

公开(公告)号：US20200347041A1

公开(公告)日：2020-11-05

申请号：US16862608

申请日：2020-04-30

申请人： Boehringer Ingelheim International GmbH

发明人： Joe Ju GAO ,  Peter SIEGER ,  Bing-Shiou YANG

IPC分类号： C07D413/04

摘要： Disclosed are solid forms of an inhibitor of glycine transporter-1 (GlyT1). The invention also relates to methods of making these solid forms, pharmaceutical compositions comprising these solid forms, and their use for medical conditions responsive to treatment with an inhibitor of glycine transporter-1.

公开(公告)号：US20240279230A1

公开(公告)日：2024-08-22

申请号：US18544537

申请日：2023-12-19

申请人： Boehringer Ingelheim International GmbH

发明人： Ulrike WERTHMANN ,  Joe Ju GAO ,  Huayu LI ,  Jason Alan MULDER ,  Thuraya Mohamed OMAR

IPC分类号： C07D487/04 ,  A61K9/10 ,  A61K31/519

CPC分类号： C07D487/04 ,  A61K9/10 ,  A61K31/519

摘要： The present invention relates to crystalline forms of a HER2 inhibitor, processes to prepare the same, pharmaceutical compositions comprising the same and uses thereof, particularly in the treatment and/or prevention of cancer and for the preparation of a solid dispersion of the HER2 inhibitor.

公开(公告)号：US20220112183A1

公开(公告)日：2022-04-14

申请号：US17498027

申请日：2021-10-11

申请人： Boehringer Ingelheim International GmbH

发明人： Julia Regina GRIMM ,  Katrin BAER ,  Albert Josef BARTA ,  Gisela BODENBACH ,  Joe Ju GAO ,  Fredrik Lars NORDSTROM ,  Michael WIESE ,  Bing-Shiou YANG ,  Manabu NAKATANI ,  Masashi ADACHI ,  Kenji EGUSA ,  Roman Christian MESSERSCHMID ,  Daniela Maria SCHROEDER

IPC分类号： C07D413/04 ,  A61K9/20 ,  A61K31/422

摘要： The invention describes a process for reworking of a crystallization product comprising drying and homogenization. The crystallization product is crystalline [5-(methylsulfonyl)-2-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}phenyl]{(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hex-3-yl}methanone. The product is dried in a tray dryer or in a pan dryer and subsequently homogenized.

公开(公告)号：US20240199590A1

公开(公告)日：2024-06-20

申请号：US18530255

申请日：2023-12-06

申请人： Boehringer Ingelheim International GmbH

发明人： Jocelyn M. ABELLA ,  Ashish Subhash CHITRODA ,  Joe Ju GAO ,  Stephanie Cassandra KOSNIK ,  David A. HIRSH ,  Soojin KIM ,  Wenjie LI ,  Zhibin LI ,  Thomas James OFFERDAHL ,  Bing-Shiou YANG

IPC分类号： C07D405/14

CPC分类号： C07D405/14

摘要： Disclosed are solid forms of an activator of soluble guanylate cyclase (sGC). The invention also relates to methods of making these solid forms, pharmaceutical compositions comprising these solid forms, and their use for medical conditions responsive to treatment with an activator of sGC.

公开(公告)号：US20240083889A1

公开(公告)日：2024-03-14

申请号：US18237423

申请日：2023-08-24

申请人： Boehringer Ingelheim International GmbH

发明人： Katrin BAER ,  Gisela BODENBACH ,  Jack Delbert BROWN ,  Rosemarie Karoline COLLET ,  Daniel HERKOMMER ,  Rogelio P. FRUTOS ,  Joe Ju GAO ,  Julia Regina GRIMM ,  Sandra KOCH ,  Sonia RODRIGUEZ ,  Svetlana SEHL-OLLENBERGER ,  Joshua Daniel SIEBER ,  Thomas G. TAMPONE ,  Ulrich THEIS ,  Dirk WEBER ,  Erik WEIS ,  Anke WILD

IPC分类号： C07D413/04

CPC分类号： C07D413/04

摘要： This invention relates to a synthetic method for the preparation of Compound 1 and precursors thereof. Compound 1 is prepared via reaction of isoxazole 2 with phenylether (R)-3-ONa.