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![Substituted 1H-pyrazolo[4,3-c]pyridines and derivatives as EGFR inhibitors](/abs-image/US/2024/08/20/US12064421B2/abs.jpg.150x150.jpg)
公开(公告)号：US12064421B2
公开(公告)日：2024-08-20
申请号：US17514145
申请日：2021-10-29
发明人： Harald Engelhardt , Mark Petronczki , Juergen Ramharter , Ulrich Reiser , Heinz Stadtmueller , Dirk Scharn , Tobias Wunberg
IPC分类号： C07D211/04 , A61K31/437 , A61K31/4545 , A61K31/4995 , A61K31/553 , A61P35/00 , C07D519/00 , A61K31/496 , A61K31/5377 , A61K31/5386 , A61K31/541
CPC分类号： A61K31/437 , A61K31/4545 , A61K31/4995 , A61K31/553 , A61P35/00 , C07D211/04 , C07D519/00 , A61K31/496 , A61K31/5377 , A61K31/5386 , A61K31/541
摘要： The present invention encompasses compounds of formula (I)
wherein the groups R1 to R4 and X1 to X5 have the meanings given in the claims and specification, their use as inhibitors of mutant EGFR, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.-
公开(公告)号：US11213520B2
公开(公告)日：2022-01-04
申请号：US16301218
申请日：2017-05-19
发明人： Harald Engelhardt , Heribert Arnhof , Sebastian Carotta , Marco Hans Hofmann , Marc Kerenyi , Dirk Scharn
IPC分类号： A61K31/4725 , A61K31/4375 , C07D401/10 , C07D401/14 , C07D471/04
摘要： The present invention encompasses compounds of formula (I) wherein the groups R2 to R5, A, X and q have the meanings given in the claims and specification, their use as inhibitors of CDK8/19, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.
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![[1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors](/abs-image/US/2022/03/01/US11261184B2/abs.jpg.150x150.jpg)
公开(公告)号：US11261184B2
公开(公告)日：2022-03-01
申请号：US16650034
申请日：2018-10-01
发明人： Harald Engelhardt , Heribert Arnhof , Sebastian Carotta , Marco Hofmann , Marc Kerenyi , Dirk Scharn
IPC分类号： C07D471/04 , A61K45/06 , A61P35/02 , C07D519/00
摘要： The present invention encompasses compounds of formula (I) wherein the groups R1 to R5, A and q have the meanings given in the claims and specification, their use as inhibitors of CDK8/19, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.
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![Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors](/abs-image/US/2023/03/21/US11608343B2/abs.jpg.150x150.jpg)
公开(公告)号：US11608343B2
公开(公告)日：2023-03-21
申请号：US17223132
申请日：2021-04-06
发明人： Birgit Wilding , Dietrich Boese , Harald Engelhardt , Julian Fuchs , Ralph Neumueller , Mark Petronczki , Dirk Scharn , Matthias Treu
IPC分类号： A61K31/519 , C07D487/04 , A61K47/26 , A61K47/32 , A61K47/36 , C07D519/00
摘要： The present invention relates to new [1,3]diazino[5,4-d]pyrimidines and derivatives of Formula (I) wherein the groups R1, R2, R3 and R4 have the meanings given in the claims and specification, their use as inhibitors of HER2 and its mutants, pharmaceutical compositions which contain such compounds and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.
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公开(公告)号：US11174245B2
公开(公告)日：2021-11-16
申请号：US16970705
申请日：2019-02-20
IPC分类号： C07D401/14 , A61K31/4355 , A61K31/437 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5025 , A61K31/519 , A61K31/5355 , A61K31/5377 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/048 , C07D491/107 , C07D498/04
摘要： The present invention encompasses compounds of formula (I) (I), wherein the groups R1 to R5 have the meanings given in the claims and specification, their use as inhibitors of mutant EGFR, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
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