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公开(公告)号：US20240279230A1
公开(公告)日：2024-08-22
申请号：US18544537
申请日：2023-12-19
IPC分类号： C07D487/04 , A61K9/10 , A61K31/519
CPC分类号： C07D487/04 , A61K9/10 , A61K31/519
摘要： The present invention relates to crystalline forms of a HER2 inhibitor, processes to prepare the same, pharmaceutical compositions comprising the same and uses thereof, particularly in the treatment and/or prevention of cancer and for the preparation of a solid dispersion of the HER2 inhibitor.
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2.发明申请公开(公告)号：US20180072754A1
公开(公告)日：2018-03-15
申请号：US15698859
申请日：2017-09-08
发明人： Pascale Arielle Jane-Josee POUZET , Peter NICKOLAUS , Ulrike WERTHMANN , Rogelio P. FRUTOS , Bing-Shiou YANG , Soojin KIM , Jason Alan MULDER , Nitinchandra D. PATEL , Chris Hugh SENANAYAKE , Thomas Gabriel TAMPONE , Xudong WEI
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
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3.发明申请NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA 审中-公开新型哌啶二氢吲哚尼酮硫代磷酸酯及其用于治疗COPD和ASTHMA的用途公开(公告)号：US20170008903A9
公开(公告)日：2017-01-12
申请号：US13963513
申请日：2013-08-09
发明人： Pascale A.J. POUZET , Peter NICKOLAUS , Ulrike WERTHMANN , Rogelio P. FRUTOS , Bing-Shiou YANG , Soojin KIM , Jason Alan MULDER , Nitinchandra D. PATEL , Chris Hugh SENANAYAKE , Thomas Gabriel TAMPONE , Xudong WEI
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
摘要翻译： 式I的哌啶子基 - 二氢噻吩并嘧啶亚砜其中：环A是任选地包含一个或两个氮原子并且R是Cl并且位于环A的对位，间位或邻位的6元芳香环，S * 是表示手性中心的硫原子及其所有药学上可接受的盐，对映异构体和外消旋体，水合物和溶剂合物，以及这些化合物用于治疗呼吸道炎症或过敏性疾病如COPD或哮喘的用途。
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4.发明申请公开(公告)号：US20200048278A1
公开(公告)日：2020-02-13
申请号：US16599209
申请日：2019-10-11
发明人： Pascale Arielle Jane-Josee POUZET , Peter NICKOLAUS , Ulrike WERTHMANN , Rogelio P. FRUTOS , Bing-Shiou YANG , Soojin KIM , Jason Alan MULDER , Nitinchandra D. PATEL , Chris Hugh SENANAYAKE , Thomas Gabriel TAMPONE , Xudong WEI
IPC分类号： C07D495/04
摘要： Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
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