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公开(公告)号：US20130012702A1
公开(公告)日：2013-01-10
申请号：US13618090
申请日：2012-09-14
申请人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
发明人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
IPC分类号： C07D413/06 , C07D209/96 , C07D403/10 , C07D265/14
CPC分类号： C07D403/04 , C07D209/96 , C07D405/04 , C07D413/04
摘要： Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
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公开(公告)号：US07786297B2
公开(公告)日：2010-08-31
申请号：US11412016
申请日：2006-04-26
申请人： Ramarao Chatlapalli , Arwinder Nagi , John Potoski , Jean Louise Helom , Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Vladimir Dragan
发明人： Ramarao Chatlapalli , Arwinder Nagi , John Potoski , Jean Louise Helom , Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Vladimir Dragan
IPC分类号： C07D265/14
CPC分类号： C07D265/14 , C07D413/04
摘要： Micronized tanaproget, purified tanaproget Form I, and micronized, purified tanaproget Form I are provided. Also provided are compositions containing one or more of the prepared tanaproget forms, methods of using one or more of the prepared tanaproget forms, and kits containing one or more of the prepared tanaproget forms.
摘要翻译： 提供微粉化的钠盐瓶，纯化的tanaproget Form I和微粉化的纯化的Tanaproget Form I。 还提供了含有一种或多种所制备的钛酸钠形式的组合物，使用一种或多种所制备的钛酸钠形式的方法，以及包含一种或多种所制备的钛酸钠形式的试剂盒。
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公开(公告)号：US07514466B2
公开(公告)日：2009-04-07
申请号：US11113730
申请日：2005-04-25
申请人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
发明人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
CPC分类号： C07D403/04 , C07D209/96 , C07D405/04 , C07D413/04
摘要： Methods for purifying a compound of formula I are provided, wherein A, B X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
摘要翻译： 提供了纯化式I化合物的方法，其中A，B X，Q和R 1在本文中定义。 所述方法包括将式I化合物和溶剂混合; 向溶剂中加入碱; 并沉淀出纯化的式I化合物。
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4.发明授权Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls 失效用于产生N-取代的吡咯-2-碳腈的反应性含硼衍生物以产生联芳基的偶联方法公开(公告)号：US08129523B2
公开(公告)日：2012-03-06
申请号：US12238530
申请日：2008-09-26
IPC分类号： C07D265/12
CPC分类号： C07D413/04 , C07F5/025
摘要： A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
摘要翻译： 提供了含硼化合物，硼酸盐，含有吡咯甲腈的硼化合物，N-取代吡咯-2-腈含硼化合物及其衍生物的方便的制备方法。 本发明还提供这些含硼化合物及其衍生物在偶联反应中的用途，以提供双芳基化合物。
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公开(公告)号：US08309594B2
公开(公告)日：2012-11-13
申请号：US12369775
申请日：2009-02-12
申请人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
发明人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
IPC分类号： A01N43/318 , A61K31/40
CPC分类号： C07D403/04 , C07D209/96 , C07D405/04 , C07D413/04
摘要： Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
摘要翻译： 提供了纯化式I化合物的方法，其中A，B，X，Q和R 1在本文中定义。 所述方法包括将式I化合物和溶剂混合; 向溶剂中加入碱; 并沉淀出纯化的式I化合物。
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公开(公告)号：US20090143577A1
公开(公告)日：2009-06-04
申请号：US12369775
申请日：2009-02-12
申请人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
发明人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
IPC分类号： C07D265/14 , C07D265/12 , C07D498/10
CPC分类号： C07D403/04 , C07D209/96 , C07D405/04 , C07D413/04
摘要： Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
摘要翻译： 提供了纯化式I化合物的方法，其中A，B，X，Q和R 1在本文中定义。 所述方法包括将式I化合物和溶剂混合; 向溶剂中加入碱; 并沉淀出纯化的式I化合物。
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7.发明申请COUPLING PROCESS FOR GENERATING REACTIVE BORON-CONTAINING DERIVATIVES OF N-SUBSTITUTED PYRROLE-2-CARBONITRILES TO PRODUCE BIARYLS 失效用于生成N-取代的吡咯并 - 二氧化碳的反应性含硼含量衍生物的制备方法公开(公告)号：US20090054663A1
公开(公告)日：2009-02-26
申请号：US12238530
申请日：2008-09-26
IPC分类号： C07F5/02
CPC分类号： C07D413/04 , C07F5/025
摘要： A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
摘要翻译： 提供了含硼化合物，硼酸盐，含有吡咯甲腈的硼化合物，N-取代吡咯-2-腈含硼化合物及其衍生物的方便的制备方法。 本发明还提供这些含硼化合物及其衍生物在偶联反应中的用途，以提供双芳基化合物。
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公开(公告)号：US08609712B2
公开(公告)日：2013-12-17
申请号：US13618090
申请日：2012-09-14
申请人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
发明人： Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Anthony Francis Hadfield , Jean Louise Helom
CPC分类号： C07D403/04 , C07D209/96 , C07D405/04 , C07D413/04
摘要： Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
摘要翻译： 提供了纯化式I化合物的方法，其中A，B，X，Q和R 1在本文中定义。 所述方法包括将式I化合物和溶剂混合; 向溶剂中加入碱; 并沉淀出纯化的式I化合物。
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9.发明授权Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls 失效用于产生N-取代的吡咯-2-碳腈的反应性含硼衍生物以产生联芳基的偶联方法公开(公告)号：US07446211B2
公开(公告)日：2008-11-04
申请号：US11113794
申请日：2005-04-25
IPC分类号： C07F5/02
CPC分类号： C07D413/04 , C07F5/025
摘要： A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
摘要翻译： 提供了含硼化合物，硼酸盐，含有吡咯甲腈的硼化合物，N-取代吡咯-2-腈含硼化合物及其衍生物的方便的制备方法。 本发明还提供这些含硼化合物及其衍生物在偶联反应中的用途，以提供双芳基化合物。
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公开(公告)号：US07399870B2
公开(公告)日：2008-07-15
申请号：US11086061
申请日：2005-03-22
IPC分类号： C07D207/30
CPC分类号： C07D207/34
摘要： The instant invention concerns processes for the production of pyrrole-2-carbonitriles such as 1-methylpyrrole-2-carbonitrile. Such processes preferably comprise the steps of reacting a pyrrole with chlorosulfonyl isocyanate in the presence of a solvent and contacting the resulting product with a molar excess of an amide such as N,N-dimethylformamide. The product of this contacting step is then contacted with a molar excess of an organic base to produce a precipitate and a solution phase. The precipitate is then separated from the solution phase and the corresponding pyrrole-2-carbonitrile is isolated from the resulting solution phase.
摘要翻译： 本发明涉及吡咯-2-碳腈如1-甲基吡咯-2-腈的制备方法。 这样的方法优选包括在溶剂存在下使吡咯与氯磺酰基异氰酸酯反应并使所得产物与摩尔过量的酰胺如N，N-二甲基甲酰胺接触的步骤。 然后将该接触步骤的产物与摩尔过量的有机碱接触以产生沉淀物和溶液相。 然后将沉淀物与溶液相分离，并从所得溶液相中分离相应的吡咯-2-腈。
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