专利检索 ap:("Bonnie L. Bassler" OR "Wai-Leung Ng" OR "Lark J. Perez" OR "Jianping Cong" OR "Martin F. Semmelhack") AND inv:"Lark J. Perez" 第 1 页

1.

发明授权
Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios 有权
标题翻译：广谱原位感应分子作为弧菌中毒力的抑制剂

公开(公告)号：US09573908B2

公开(公告)日：2017-02-21

申请号：US14381432

申请日：2013-02-20

申请人： Bonnie L. Bassler , Wai-Leung Ng , Lark J. Perez , Jianping Cong , Martin F. Semmelhack

发明人： Bonnie L. Bassler , Wai-Leung Ng , Lark J. Perez , Jianping Cong , Martin F. Semmelhack

IPC分类号： C07D253/075 , A61K31/53 , A61P31/04 , A01N43/707 , A01N55/00 , C07F7/10

CPC分类号： C07D253/075 , A01N43/707 , A01N55/00 , A61K31/53 , C07F7/10

摘要： Using a whole-cell high-throughput screen, eleven molecules were identified that activate V. cholerae quorum sensing (QS). Eight molecules are receptor agonists and three molecules are antagonists of LuxO, the central NtrC-type response regulator that controls the global V. cholerae QS cascade. Pro-QS molecules are used for the development of novel anti-infectives.

摘要翻译： 使用全细胞高通量筛选，鉴定了激活霍乱弧菌感染（QS）的11个分子。八个分子是受体激动剂，三个分子是LuxO的拮抗剂，LuxO是控制全球霍乱弧菌QS级联的中枢NtrC型应答调节剂。 Pro-QS分子用于开发新型抗感染药。